To further understand the mechanisms of action, experiments are conducted to study the effects of these compounds on DNA topology, DNA cleavage, and protein-DNA interactions. These assays help confirm whether the hybrid compounds are effectively covalently binding to both topoisomerase II and DNA.
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4β-chloroacetamido-4-deoxy-4′-desmethylepipdophyllotoxin
(4-Amino-3-iodophenyl)acetic acid
1-methoxy-5-nitro-4-phenylisoquinoline
2-([1,1'-biphenyl]-4-yl)-N-(4-methoxybenzyl)acetamide
(1-(5-chloro-2-methoxyphenyl)-1H-1,2,3-triazol-4-yl)(phenyl)methanone
N-(2-amino-6-(4-methoxyphenyl)pyrimidin-4-yl)methanesulfonamide
6-{2-[2,3-dichloro-4-(2-methylenebutyryl)phenoxy]acetylamino}hexanoic acid
(2S,3R,4R,5S,6R)-2-(4-chloro-3-((5-(furan-2-yl)thiazol-2-yl)methyl)phenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
2-aza-4'-demethyldeoxypodophyllotoxin
7-bromo-N-[(1-oxyl-4-bromo-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl]-9H-fluoren-2-amine radical
(2aR,4S,4aS,6R,9S,11S,12S,12bS)-6,12b-bis(acetyloxy)-9-({(2R,3S)-3-(benzoylamino)-3-phenyl-2-[(triethylsilyl)oxy]propanoyl}oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9, 10,11,12,12a,12bdodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate
4-(4-{[(9H-fluoren-9-ylmethoxycarbonyl)prop-2-ynylamino]methyl}-3,5-dimethoxyphenoxy)butyric acid
1,2,3,4-tetrakis-O-(3,4,5-trihydroxybenzoyl)-alpha-D-glucopyranose
5-BROMO-2-[(4-CHLOROBENZYL)OXY]BENZALDEHYDE
1-(4-(3-Methoxy-4-nitrophenyl)piperazin-1-yl)ethanone
ethyl (2R,5R)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]-8,8-dimethyl-7,9-dioxatricyclo[4.3.0.02,4]nonane-2-carboxylate
3-{[(1S)-1-phenylethyl]amino}-4-(pyridin-4-ylamino)cyclobut-3-ene-1,2-dione
ethyl (8R,9S)-8-[[(1R)-1-phenylethyl]amino]-1,4-dioxaspiro[4.5]decane-9-carboxylate
1-(5-METHYL-4-ISOXAZOLYL)-1-ETHANONE
methyl 3-(phenethylcarbamoyl)propylcarbamate
2',3'-di-O-mesyl-5-methyl-5'-O-trityl-2',3'-secouridine
12-iodocytochalasin C
Boc-D-Lys(Cl-Z)-D-Leu-Pro-OMe
C16H18N4O2
L-Proline, 1-(1,2-dioxo-3-phenylpropyl)-, phenylmethyl ester
C27H39N5O8S
Glycine, N-[(3,5-difluorophenyl)acetyl]-L-alanyl-2-phenyl-, (2S)-
C24H28N6O8S2
2-MERCAPTO-6-THIEN-2-YL-4-(TRIFLUOROMETHYL)-PYRIDINE-3-CARBONITRILE
C23H13F4NO
5
7
(2R,3S,4R,5R)-5-((benzoyloxy)methyl)-3-chlorotetrahydrofuran-2,4-diyl dibenzoate
1-(cyclohexylmethyl)-4-iodo-1H-pyrazole
ethyl 5-(4-(4-fluorobenzamido)phenyl)isoxazole-3-carboxylate
HCl
ethyl 2-benzoyl-5-phenyl-1-(4-(phenylethynyl)phenyl)-1H-pyrrole-3-carboxylate
N-[4-(imidazo[1,2-b]pyridazin-6-yloxy)phenyl]-N'-phenylurea
2-Amino-9-{2-[(diisopropoxyphosphoryl)methoxy]ethyl}-6-phenylpurine
2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-3,4-dihydro-2H-1-benzopyran-6-yl 2,6-di{[(benzyloxy)carbonyl]amino}hexanoate
α-tocopherol
1-(4-cyanophenyl)-2-(4-nitrophenyl)-1,2-dicarba-closo-dodecaborane
(2-fluoro-5-nitrophenyl)-N-(4-methoxybenzyl)-methanamine
(4,4′,5,5′-tetrachloro-1′H-1,3′-bipyrrole-2,2′-diyl)bis((5-chloro-2-hydroxy-4-methylphenyl)methanone)
Tetrahydrofuran
acetonitrile
Quinoline-5-sulfonyl Chloride
2-(4-Aminophenyl)-5,6-dimethyl benzimidazole
C32H56ClO4P
