The information gained from SAR studies and pharmacological evaluations is used to optimize the chemical structure of these derivatives. The goal is to identify lead compounds that demonstrate the desired positive inotropic effects with high selectivity and minimal toxicity. These lead compounds can then be further developed into potential drug candidates for clinical trials.
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1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine
