Journal of Medicinal Chemistry p. 4509 - 4515 (1992)
Update date:2022-07-29
Topics: Pharmacological evaluation Regulatory Considerations Structure-Activity Relationship (SAR) Synthesis of 6-Substituted Purine Derivatives Selectivity as Positive Inotropes Target Receptors or Pathways Optimization and Drug Development
Press
Falotico
Hajos
Sawyers
Kanojia
Williams
Haertlein
Kauffman
Lakas-Weiss
Salata
A series of purine derivatives was prepared and examined for selective inotropic activity in vitro and in vivo. Thioether-linked derivatives were superior to their oxygen and nitrogen isosteres. Substitution of electron- withdrawing groups on the benzhydryl moiety of these agents increased potency. The best compound of the study, 17 (carsatrin), was examined further and demonstrated selective oral activity as a positive inotrope. These compounds are presumed to act by affecting the kinetics of the cardiac sodium channel by analogy to the prototypic agent DPI 201106 (1). Their high selectivity for increasing contractile force and dP/dt without affecting blood pressure or heart rate is consistent with this mechanism. Carsatrin (17) was selected as a potential development candidate.
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