Journal of Medicinal Chemistry p. 4509 - 4515 (1992)
Update date:2022-07-29
Topics: Pharmacological evaluation Regulatory Considerations Structure-Activity Relationship (SAR)
Press
Falotico
Hajos
Sawyers
Kanojia
Williams
Haertlein
Kauffman
Lakas-Weiss
Salata
A series of purine derivatives was prepared and examined for selective inotropic activity in vitro and in vivo. Thioether-linked derivatives were superior to their oxygen and nitrogen isosteres. Substitution of electron- withdrawing groups on the benzhydryl moiety of these agents increased potency. The best compound of the study, 17 (carsatrin), was examined further and demonstrated selective oral activity as a positive inotrope. These compounds are presumed to act by affecting the kinetics of the cardiac sodium channel by analogy to the prototypic agent DPI 201106 (1). Their high selectivity for increasing contractile force and dP/dt without affecting blood pressure or heart rate is consistent with this mechanism. Carsatrin (17) was selected as a potential development candidate.
View MoreLyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Contact:0755-28995781
Address:shenzhen
Suzhou Sibian Chemical Technology Co., Ltd
website:http://www.sibianpharm.com
Contact:+8618169181984,+8618013186906
Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
Beijing Green Guardee Technology CO,.LTD
Contact:+86-10-69706062
Address:F2 BLdj,5 No.37 Chaoqian Road
Shanghai Egoal Chemical Co.,Ltd
Contact:+86-21-50333091
Address:Yangming Garden Square 3,YangGao North Road 1188, Pudong New District, Shanghai
Doi:10.1039/c0dt00736f
(2010)Doi:10.1039/c3ob42183j
(2014)Doi:10.1016/j.ica.2010.05.058
(2010)Doi:10.1002/chem.201002183
(2010)Doi:10.1002/chem.201000947
(2010)Doi:10.1002/anie.201003424
(2010)