Changes to the size or nature of the rings within the structure, such as converting a six-membered ring to a five-membered ring, can impact the conformation and binding properties of the compound.
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t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate
bufalin 3-[N-(tert-butoxycarbonyl)hydrazido]succinate
