Structure-activity relationships in 3-oxo-1,4-benzodiazepine-2-acetic acid GPIIb/IIIa antagonists. The 2-benzazepine series

DOI: 10.1016/0960-894X(96)00432-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2481 - 2486 (1996)

Update date:2022-08-03

Topics: Stereochemistry Substituent Position Aromatic Rings Functional Groups Ring Modifications Isosteres

Authors:

Miller, William H.

Ali, Fadia E.

Bondinell, William E.

Callahan, James F.

Calvo, Raul R.

Eggleston, Drake S.

Haltiwanger, R. Curtis

Huffman, William F.

Hwang, Shing-Mei

Jakas, Dalia R.

Keenan, Richard M.

Koster, Paul F.

Ku, Thomas W.

Kwon, Chet

Newlander, Kenneth A.

Nichols, Andrew J.

Parker, Michael F.

Samanen, James M.

Southall, Linda S.

Takata, Dennis T.

Uzinskas, Irene N.

Valocik, Richard E.

Vasko-Moser, Janice A.

Wong, Angela S.

Yellin, Tobias O.

Yuan, Catherine C. K.

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Article abstract of DOI:10.1016/0960-894X(96)00432-5

In an investigation of the contribution of N-1 to the binding, antiaggregatory, and oral activity in 3-oxo-1,4-benzodiazepine-2-acetic acid based GPIIb/IIIa antagonists, a series of 2-benzazepine analogs, wherein N-1 of the 1,4-benzodiazepine nucleus has

Full text of DOI:10.1016/0960-894X(96)00432-5

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