Replacing specific groups with isosteric or bioisosteric groups may be explored to improve activity or address issues related to toxicology or metabolism.
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t-butyl 3-bromo-4-[[N-t-butoxycarbonyl-N-methoxycarbonyl]amino]methylbenzoate
(S)-4-((E)-(R)-1-Fluoro-hexadec-2-enyl)-2-phenyl-4,5-dihydro-oxazole
(1S,3R,4S,5R,6S,7S)-ethyl 4,5-bis(benzyloxy)-3-((tert-butyldimethylsilyloxy)methyl)-2-oxabicyclo[4.1.0]heptane-7-carboxylate
(4S,R)-3-(benzyloxycarbonyl)-4-(phenylmethyl)-4-<1-(2-propenyl)>-5-oxooxazolidine
5,9-anhydro-6,7,8,10-tetra-O-benzyl-2,3,4-trideoxy-2-(tert-butoxycarbonylamino)-D-threo-L-galacto-deconic acid
2-(N-benzyl-N-tert-butoxycarbonylphenylalanyl)-1,3-thiazole
