Secondary amines (R2NH) are less nucleophilic compared to primary amines because they lack the additional hydrogen on the nitrogen. They can still participate in nucleophilic substitution reactions but may require more forcing conditions or a more reactive electrophile. In acetonitrile, secondary amines can react with alkyl halides, acyl halides, and other electrophiles, but the reactions may be slower compared to primary amines.
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[bis(4-dimethylaminophenyl)methyl]-(2,2,2-trifluoroethyl)amine
7
15
1,3-dimethyl-2-oxo-2,3-dihydro-1H-imidazole-4-carboxylic acid
N-(2-chlorobenzyl)-N,5-dimethylbenzoxazol-2-amine
4-Piperazinobenzonitrile
4-Piperazinobenzonitrile
6-BENZYLAMINO-1-HEXANOL
1-cyclohexyl-3-(4-acetylphenyl)-1-methyl-urea
3-(4-oxopiperidin-1-yl)propanenitrile
Methanamine, N-(phenyl-1H-pyrrol-2-ylmethylene)-
2-(2-Dimethylamino-ethyl)-6-methyl-4-phenyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid dimethyl ester
Piperidine, 1-(2,7-octadienyl)-
3-Penten-2-one, 1,1,1,3,5,5,5-heptafluoro-4-(trifluoromethyl)-
4-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-benzenemethanamine
2,3-dinitro-1,4-dipiperidino-buta-1,3-diene
