Stability testing

Analysis of a conjugate’s degradation under various conditions.

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Synthesis and biological evaluation of PEG-tirofiban conjugates
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Synthesis Antifungal Spectrophotometry Triazole Lipophilicity In vitro Antimicrobial activity Synthetic route Hydrolysis Mass spectrometry (MS) High-performance liquid chromatography (HPLC) PEGylation HPLC (high-performance liquid chromatography) Azole NMR (nuclear magnetic resonance) Nuclear Magnetic Resonance (NMR) Ring cleavage in vivo Purification Biological Evaluation Nucleophilic Attack Zone of Inhibition Structure-Activity Relationship (SAR) Pharmacokinetics Deuterium Source MIC Determination Bioavailability Cytotoxicity Assay Dose-Response Curve Enzymatic Hydrolysis Tautomerization Kinetic Isotope Effect (KIE) Oxidative Stress Conjugate Mechanistic study Cell viability assay Animal model Reaction yield Enzyme inhibition assay Cephalosporin Amide bond Metabolite Electrophilic center Toxicity testing Metabolic profiling Deuterated solvent Linker Degradation Pathway Ester bond NMR spectroscopy (Nuclear Magnetic Resonance)

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