a. Start with the purified mono-substituted pyrimidine. b. Choose an appropriate boronic acid or boronate ester as the second coupling partner. This compound should have the desired substituent for the third position on the pyrimidine ring. c. Introduce a palladium catalyst (e.g., Pd(PPh3)4) and a base (e.g., potassium carbonate) to facilitate the Suzuki cross-coupling reaction. d. Conduct the Suzuki reaction under suitable conditions to couple the boronic acid or boronate ester with the mono-substituted pyrimidine. This will lead to the formation of a trisubstituted pyrimidine. e. The boronic acid or boronate ester should contain the desired substituent for the third position on the pyrimidine ring.
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Pyrimidine, 5-chloro-2-phenyl-4-(1-piperidinyl)-
benzyl (6-(6-oxocyclohex-1-en-1-yl)benzo[d][1,3]dioxol-5-ylmethyl)carbamate
[Pd(μ-Cl)(κ2-(C,C)-(4-phenylbenzoylmethyl)triphenylphosphorane(-H))(PPh3)]
1-CHLORO-3,4-DIHYDRO-2-NAPHTHALENECARBALDEHYDE
4-(1-benzyl-2-ethyl-4-nitro-1H-imidazol-5-yl)benzoic acid
[(2,6-(Ph2PO)C6H3(CHNPh))PdCl]
3-anilino-1-(4-methoxy-phenyl)-propenone
3-(4-methoxyphenyl)-5-(methylsulfonyl)pyridine
