Employ organolithium reagents, such as n-BuLi or t-BuLi, to generate a nucleophilic species that can be alkylated. This can be a direct alkylation or used in conjunction with other reactions like a subsequent trapping with an electrophile.
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tert-butyl 6'-benzyl-N-tert-butyl-7'-oxo-6',7'-dihydro-2'H-spiro[piperidine-4,5'-pyrano[3,2-c]pyrazole]-1-carboxylate
