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| Name |
Trilostane |
EINECS | 237-133-0 |
| CAS No. | 13647-35-3 | Density | 1.25 g/cm3 |
| PSA | 76.78000 | LogP | 3.46688 |
| Solubility | N/A | Melting Point |
264 °C |
| Formula | C20H27NO3 | Boiling Point | 497.8 °C at 760 mmHg |
| Molecular Weight | 329.439 | Flash Point | 254.8 °C |
| Transport Information | N/A | Appearance | tan crystals |
| Safety | 26-36/37 | Risk Codes | 36/37/38-62 |
| Molecular Structure |
|
Hazard Symbols | Xi |
| Synonyms |
Desopan;Modrastane;Modrefen;Modrenal;5-alpha-Androstane-2-alpha-carbonitrile, 4-alpha,5-epoxy-17-;Vetoryl;Win 24540;(2-alpha,4-alpha,5-alpha,17-beta)-4,5-Epoxy-17-hydroxy-3-; |
Trilostane Chemical Properties
CAS: 13647-35-3
Molecular Formula: C20H27NO3
Molecular Weight: 329.43
Molecular structure:
EINECS: 237-133-0
Melting point: 264 °C
Index of Refraction: 1.582
Molar Refractivity: 87.66 cm3
Molar Volume: 262.5 cm3
Polarizability: 34.75 10-24cm3
Surface Tension: 54.1 dyne/cm
Density: 1.25 g/cm3
Flash Point: 266.1 °C
Enthalpy of Vaporization: 90.75 kJ/mol
Boiling Point: 516.5 °C at 760 mmHg
Vapour Pressure: 7.95E-13 mmHg at 25°C
Trilostane Uses
Trilostane (CAS NO.13647-35-3) is commonly used as an inhibitor of 3 -hydroxysteroid dehydrogenase used in the treatment of cushing's syndrome.
Trilostane Toxicity Data With Reference
| 1. | ipr-rat LD50:1275 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 17 (1986),365. | ||
| 2. | scu-rat LD50:7050 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 17 (1986),365. | ||
| 3. | ivn-rat LD50:102 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 17 (1986),365. | ||
| 4. | ipr-mus LD50:1552 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 17 (1986),365. | ||
| 5. | ivn-mus LD50:109 mg/kg | IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 17 (1986),365. |
Trilostane Safety Profile
Poison by intravenous route. Moderately toxic by intraperitoneal route. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Trilostane Specification
Trilostane (CAS NO.13647-35-3) is also named as (2-alpha,4-alpha,5-alpha,17-beta)-4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-car ; 17-beta)-Ph ; 4-alpha,5-epoxy-17-beta-Hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril ; 4-alpha,5-Epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile ; 4-alpha-5-Epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril ; Androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al ; Modrenal and so on.
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