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hydrogenchloride
tripelennamine hydrochloride
N-benzyl-N',N'-dimethyl-N-(2-pyridinio)-1,2-ethanediammonium tetrachlorocobaltate(II)
Conditions | Yield |
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In hydrogenchloride equimolar amts. of CoCl2 and ligand, 6 M HCl; crystn. overnight, washing (EtOH), recrystn. (MeCN, room temp., slow evapn); |
tripelennamine hydrochloride
Conditions | Yield |
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In water pH=8; |
The Tripelennamine hydrochloride, also known as 1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, monohydrochloride, is an organic compound with the formula C16H22ClN3. Its EINECS registry number is 205-833-5. With the CAS registry number 154-69-8, its IUPAC name is N'-benzyl-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine hydrochloride. Tripelennamine hydrochloride is a white, crystalline material which is stable, nonhygroscopic, and readily soluble in water. Tripelennamine hydrochloride is characterized by its capacity to antagonize many of the pharmacologic effects of histamine.
Physical properties of Tripelennamine hydrochloride are: (1)ACD/LogP: 2.78; (2)ACD/LogD (pH 5.5): -0.32; (3)ACD/LogD (pH 7.4): 0.86; (4)ACD/BCF (pH 5.5): 1.00 ; (5)ACD/BCF (pH 7.4): 1.00; (6)ACD/KOC (pH 5.5):1.00; (7)ACD/KOC (pH 7.4): 9.21; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 6; (10)Index of Refraction: 1.594; (11)Molar Refractivity: 80.765 cm3; (12)Molar Volume: 238.124 cm3; (13)Polarizability: 32.018 10-24cm3; (14)Surface Tension: 46.1459999084473 dyne/cm; (15)Density: 1.072 g/cm3; (16)Flash Point: 188.343 °C; (17)Enthalpy of Vaporization: 63.693 kJ/mol; (18)Boiling Point: 387.814 °C at 760 mmHg
When you are using this chemical, please be cautious about it as the following:
This chemical may cause damage to health. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.
You can still convert the following datas into molecular structure:
(1)Canonical SMILES: CN(C)CCN(CC1=CC=CC=C1)C2=CC=CC=N2.Cl
(2)InChI: InChI=1S/C16H21N3.ClH/c1-18(2)12-13-19(16-10-6-7-11-17-16)14-15-8-4-3-5-9-15;/h3-11H,12-14H2,1-2H3;1H
(3)InChIKey: FSSICIQKZGUEAE-UHFFFAOYSA-N
The toxicity data is as follows:
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 20mg/kg (20mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1916, 1969. | |
dog | LDLo | oral | 23mg/kg (23mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: EXCITEMENT | Bulletin of the Johns Hopkins Hospital. Vol. 81, Pg. 55, 1947. |
guinea pig | LD50 | oral | 150mg/kg (150mg/kg) | Journal of Allergy. Vol. 27, Pg. 57, 1956. | |
guinea pig | LD50 | subcutaneous | 30mg/kg (30mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) BEHAVIORAL: TREMOR | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
hamster | LD50 | intravenous | 13mg/kg (13mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: TREMOR | Journal of Pharmacology and Experimental Therapeutics. Vol. 97, Pg. 371, 1949. |
man | LDLo | unreported | 15mg/kg (15mg/kg) | "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970Vol. 2, Pg. 73, 1970. | |
mouse | LD50 | intraperitoneal | 47mg/kg (47mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Clinical Toxicology. Vol. 16, Pg. 17, 1980. |
mouse | LD50 | intravenous | 9mg/kg (9mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) | Journal of Pharmacology and Experimental Therapeutics. Vol. 92, Pg. 249, 1948. |
mouse | LD50 | oral | 97mg/kg (97mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 488, 1950. | |
mouse | LD50 | subcutaneous | 41mg/kg (41mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: TREMOR | Journal of Pharmacology and Experimental Therapeutics. Vol. 113, Pg. 72, 1955. |
rabbit | LD50 | intravenous | 9mg/kg (9mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946. |
rabbit | LD50 | subcutaneous | 33mg/kg (33mg/kg) | BEHAVIORAL: EXCITEMENT BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946. |
rat | LD50 | intravenous | 12mg/kg (12mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Journal of Laboratory and Clinical Medicine. Vol. 31, Pg. 749, 1946. |
rat | LD50 | oral | 469mg/kg (469mg/kg) | Journal of Pharmaceutical Sciences. Vol. 69, Pg. 1198, 1980. | |
rat | LD50 | subcutaneous | 75mg/kg (75mg/kg) | Proceedings of the Society for Experimental Biology and Medicine. Vol. 78, Pg. 708, 1951. |