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Tween20

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Name

Tween20

EINECS 500-018-3
CAS No. 9005-64-5 Density 1.106
Solubility 100 g/L Melting Point
Formula Unspecified Boiling Point 100oC
Molecular Weight 522.66900 Flash Point 199.4oC
Transport Information Appearance
Safety Risk Codes
Molecular Structure Molecular Structure of 9005-64-5 (Tween20) Hazard Symbols
Synonyms

Sorbitan,monododecanoate, poly(oxy-1,2-ethanediyl) derivs.;Sorbitan, monolaurate, polyoxyethylene derivs. (8CI);Ahco 7596T;Alkamuls PSML 20;Alkamuls PSML 80/72;Polysorbate 20;

 

Tween20 Consensus Reports

POLYSORBATE 20(9005-64-5) is reported in EPA TSCA Inventory.

Tween20 Specification

The Tween20 with CAS registry number of 9005-64-5 is also known as Armotan pml-20. The systematic name is Polyoxyethylene sorbitan monolaurate. It belongs to classification codes of Drug/Therapeutic Agent; Excipients; Pharmaceutic aid [surfactant]; Reproductive Effect; Skin / Eye Irritant; Surface-Active Agents; TSCA Flag XU [Exempt from reporting under the Inventory Update Rule]. In addition, the formula is C58H114O26 and the molecular weight is 1227.54. Tween20 is a polyoxyethylene derivative of sorbitan monolaurate.It is yellow liquid which is stable,incompatible with strong oxidizing agents.It is complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.

Uses of Tween20:
 It is used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications. For example, it is used as a wetting agent in flavored mouth drops such as ice drops. Besides, it is used as a solubilizing agent of membrane proteins and for lysing mammalian cells. This chemical is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Safety Information of Tween20:
Tween20 is harmful if swallowed and risk of serious damage to eyes .It is irritating to eyes, respiratory system and skin .In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .When you use it ,wear suitable protective clothing, gloves and eye/face protection and avoid contact with skin and eyes.

The toxicity data of Tween20 is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
hamster LD50 oral 18mL/kg (18mL/kg)   Food Research. Vol. 21, Pg. 348, 1956.
mouse LD50 intraperitoneal 2640mg/kg (2640mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 intravenous 1420mg/kg (1420mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 316, 1970.
mouse LD50 oral > 33gm/kg (33000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 intraperitoneal 3850mg/kg (3850mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 intravenous 770mg/kg (770mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 oral 36700uL/kg (36.7mL/kg)   Food Research. Vol. 21, Pg. 348, 1956.

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