The Imidazo[1,2-a]pyridine-3-acetamide,N,N,6-trimethyl-2-(4-methylphenyl)-, with the CAS registry number 82626-48-0, is also known as Zolpidem. It belongs to the product categories of Pyridines Derivates; Intermediate of Zolpidem; Zolpidem; Amines; Heterocycles; Intermediates & Fine Chemicals and Pharmaceuticals. This chemical's molecular formula is C19H21N3O and molecular weight is 307.39. What's more, both its IUPAC name and systematic name are the same which is called N,N-Dimethyl-2-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]acetamide. This chemical is white solid and its solubility is 0.3 mg/mL in the 45% (w/v) aq 2-Hydroxypropyl-β-cyclodextrin. This chemical's classification codes are Central Nervous System Agents; Central Nervous; System Depressants; GABA Agents; Hypnotics and Sedatives; GABA Agonists and Neurotransmitter Agents. It is used as a selective benzodiazepine receptor agonist not related chemically to benzodiazepines. And it is a prescription medication used for the short-term treatment of insomnia, as well as some brain disorders.
Physical properties about Imidazo[1,2-a]pyridine-3-acetamide,N,N,6-trimethyl-2-(4-methylphenyl)- are: (1) ACD/LogP: 3.07; (2) # of Rule of 5 Violations: 0; (3) ACD/LogD (pH 5.5): 2.09; (4) ACD/LogD (pH 7.4): 3.02; (5) ACD/BCF (pH 5.5): 13.19; (6) ACD/BCF (pH 7.4): 113.38; (7) ACD/KOC (pH 5.5): 116.12; (8) ACD/KOC (pH 7.4): 113.38; (9) #H bond acceptors: 4; (10) #H bond donors: 0; (11) #Freely Rotating Bonds: 3; (12) Polar Surface Area: 37.61 Å2; (13) Index of Refraction: 1.601; (14) Molar Refractivity: 93.54 cm3; (15) Molar Volume: 273 cm3; (16) Surface Tension: 40.1 dyne/cm; (17) Density: 1.12 g/cm3; (18) Melting Point: 189-191 °C.
When you are dealing with this chemical, you should be very careful. This chemical is irritating to eyes and may cause inflammation to the skin or other mucous membranes. Therefore, you should wear suitable protective clothing and if in case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1) SMILES: CC1=CC=C(C=C1)C2=C(N3C=C(C=CC3=N2)C)CC(=O)N(C)C
(2) InChI: InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
(3) InChIKey: ZAFYATHCZYHLPB-UHFFFAOYSA-N
The toxicity data is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
| women | TDLo | oral | 200ug/kg (0.2mg/kg) | BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Journal of Clinical Psychiatry. Vol. 56, Pg. 35, 1995. |
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