Products Categories
Basic Information
| CAS No.: | 100-84-5 |
|---|---|
| Name: | 3-Methylanisole |
| Article Data: | 111 |
| Molecular Structure: | |
|
|
|
| Formula: | C8H10O |
| Molecular Weight: | 122.167 |
| Synonyms: | Anisole,m-methyl- (8CI);1-Methoxy-3-methylbenzene;3-Cresol methyl ether;3-Methoxytoluene;3-Methyl-1-methoxybenzene;Methyl m-tolylether;NSC 6255;m-Cresol methyl ether;m-Cresyl methyl ether;m-Methoxytoluene;m-Methylanisole; |
| EINECS: | 202-893-4 |
| Density: | 0.941 g/cm3 |
| Melting Point: | -47oC |
| Boiling Point: | 172.2 °C at 760 mmHg |
| Flash Point: | 54.4 °C |
| Solubility: | Soluble in alcohol and insoluble in water. |
| Appearance: | colourless liquid |
| Hazard Symbols: |
 Xn
|
| Risk Codes: | 10-22 |
| Safety: | 16-23-24/25 |
| Transport Information: | UN 1993 3/PG 3 |
| PSA: | 9.23000 |
| LogP: | 2.00360 |
Related products
- 144851-82-1METHYL2-AMINO-3-FLUOROBENZOATE
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 173606-50-3BOC-10-AMINODECANOIC ACID
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 1219080-61-1IMIDAZOLE-2-BORONIC ACID
Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| With palladium dichloride In methanol at 40℃; for 18h; Inert atmosphere; Green chemistry; chemoselective reaction; | 99% |
| With [IrCl(CO)(PPh3)2]; hydrazine hydrate; potassium hydroxide In methanol at 160℃; for 3h; Wolff-Kishner Reduction; Sealed tube; | 86% |
| With [IrCl(CO)(PPh3)2]; hydrazine hydrate; potassium hydroxide In methanol at 160℃; for 3h; Sealed tube; | 86% |
| With carbon monoxide; hydrogen; benzene unter Zusatz von Octacarbonyldikobalt und CoCO3 auf 190grad/238 at; | |
| Multi-step reaction with 3 steps 1: 78 percent / sodium iodide; sodium hydride / tetrahydrofuran / 0 - 20 °C 2: sulfuryl chloride / CH2Cl2 / -78 °C 3: lithium; 4,4'-di-tert-butylbiphenyl / tetrahydrofuran / 1 h / 0 °C View Scheme |
- 27060-75-9
4-bromo-3-methylanisole
- 100-84-5
1-methoxy-3-methyl-benzene
Conditions
| Conditions | Yield |
|---|---|
| With potassium carbonate; butan-1-ol; palladium diacetate; triphenylphosphine at 100℃; for 14h; | 98% |
- 19924-43-7
3-methoxyphenylacetonitrile
- 100-84-5
1-methoxy-3-methyl-benzene
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-methoxyphenylacetonitrile With 15-crown-5; sodium In tetrahydrofuran; hexane at 0℃; for 0.333333h; Birch Reduction; Inert atmosphere; Stage #2: With water In tetrahydrofuran; hexane at 0℃; for 1h; Birch Reduction; Inert atmosphere; chemoselective reaction; | 98% |
| Stage #1: 3-methoxyphenylacetonitrile With dibenzo-18-crown-6; sodium In tetrahydrofuran; toluene at 0℃; for 0.333333h; Inert atmosphere; Stage #2: With propan-1-ol In tetrahydrofuran; toluene at 0℃; for 1h; | 78% |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-methoxy-benzaldehyde With iron(III) chloride In methanol at 20℃; for 0.05h; Stage #2: In methanol at 20℃; for 0.166667h; chemoselective reaction; | 95% |
| With borohydride exchange resin; nickel diacetate In methanol for 3h; Ambient temperature; | 93% |
| With triethylsilane; palladium dichloride In ethanol for 0.5h; Inert atmosphere; | 86.0 %Chromat. |
| With triethylsilane; palladium dichloride In ethanol at 20℃; for 0.5h; Inert atmosphere; | 86 %Chromat. |
- 63452-69-7
1-iodo-4-methoxy-2-methylbenzene
- 100-84-5
1-methoxy-3-methyl-benzene
Conditions
| Conditions | Yield |
|---|---|
| With potassium carbonate; butan-1-ol; palladium diacetate; triphenylphosphine at 100℃; for 1h; | 93% |
Conditions
| Conditions | Yield |
|---|---|
| With benzyltrimethylammonium chloride; sodium hydroxide In water at 70℃; Concentration; Temperature; Autoclave; | 92.2% |
- 155496-74-5
1-Methoxy-3-methyl-2-(2-methyl-propane-2-sulfonyl)-benzene
- 100-84-5
1-methoxy-3-methyl-benzene
Conditions
| Conditions | Yield |
|---|---|
| With bis(acetylacetonate)nickel(II); isopropylmagnesium chloride In tetrahydrofuran at 20℃; for 20h; | 92% |
Conditions
| Conditions | Yield |
|---|---|
| In methanol for 1.6h; Methylation; | 92% |
Conditions
| Conditions | Yield |
|---|---|
| With sodium hydroxide at 50℃; for 5h; | 91.8% |
| With sodium hydroxide |
Conditions
| Conditions | Yield |
|---|---|
| With ethene; 5%-palladium/activated carbon at 130℃; under 760.051 Torr; | 88% |
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 100-84-5
3-Methylanisole
Chemistry
IUPAC Name: 1-methoxy-3-methylbenzene
The MF of 3-methylanisole(100-84-5): C8H10O
The MW of 3-methylanisole(100-84-5): 122.16
EINECS: 202-893-4
bp: 175-176 °C(lit.)
density: 0.969 g/mL at 25 °C(lit.)
refractive index: n20/D 1.513(lit.)
Fp: 130 °F
storage temp.: Flammables area
Appearance: Clear very slight yellow liquid.
Solubility in water: Insoluble
Stability: Stable. Flammable. Incompatible with strong oxidizing agents.
Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Aromatic Ethers;AnisoleSeries;Anisoles, Alkyloxy Compounds & Phenylacetates;Ethers;Organic Building Blocks;Oxygen Compounds
Synonyms: 1-METHOXY-3-METHYLBENZENE;AMBROL;3-METHOXYTOLUENE;3-METHYLANISOLE;METHYL M-TOLYL ETHER;METHYL-M-CRESOL;M-CRESOL METHYL ETHER;M-CRESYL METHYL ETHER
The Structure of 3-methylanisole(100-84-5):
The MF of 3-methylanisole(100-84-5): C8H10O
The MW of 3-methylanisole(100-84-5): 122.16
EINECS: 202-893-4
bp: 175-176 °C(lit.)
density: 0.969 g/mL at 25 °C(lit.)
refractive index: n20/D 1.513(lit.)
Fp: 130 °F
storage temp.: Flammables area
Appearance: Clear very slight yellow liquid.
Solubility in water: Insoluble
Stability: Stable. Flammable. Incompatible with strong oxidizing agents.
Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Aromatic Ethers;AnisoleSeries;Anisoles, Alkyloxy Compounds & Phenylacetates;Ethers;Organic Building Blocks;Oxygen Compounds
Synonyms: 1-METHOXY-3-METHYLBENZENE;AMBROL;3-METHOXYTOLUENE;3-METHYLANISOLE;METHYL M-TOLYL ETHER;METHYL-M-CRESOL;M-CRESOL METHYL ETHER;M-CRESYL METHYL ETHER
The Structure of 3-methylanisole(100-84-5):
Uses
3-methylanisole(100-84-5) is mainly used for synthetic dyes and pharmaceutical intermediates.
Toxicity Data With Reference
1. mouse LD intraperitoneal > 500mg/kg (500mg/kg)
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 214, 1954.
"Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 6, Pg. 214, 1954.
Safety Profile
Hazard Codes: 
Xn
Risk Statements: 10-22
10: Flammable
22: Harmful if swallowed
Safety Statements: 16-23-24/25
16: Keep away from sources of ignition - No smoking
23: Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
24/25: Avoid contact with skin and eyes
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
RTECS: BZ8778000
HazardClass: 3
PackingGroup: III
Xn Risk Statements: 10-22
10: Flammable
22: Harmful if swallowed
Safety Statements: 16-23-24/25
16: Keep away from sources of ignition - No smoking
23: Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer)
24/25: Avoid contact with skin and eyes
RIDADR: UN 1993 3/PG 3
WGK Germany: 3
RTECS: BZ8778000
HazardClass: 3
PackingGroup: III
Specification
1. First Aid Measures
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
2. Handling and Storage
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
Handling:
Wash thoroughly after handling. Use only in a well ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:
Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:
Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
2. Handling and Storage
Storage:
Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area.
Handling:
Wash thoroughly after handling. Use only in a well ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Avoid contact with heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames.