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| CAS No.: | 103-01-5 |
|---|---|
| Name: | Anilinoacetic acid |
| Molecular Structure: | |
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| Formula: | C8H9NO2 |
| Molecular Weight: | 151.165 |
| Synonyms: | H-DL-Phg-OH;TR-NPG;(Phenylamino)aceticacid;Acetic acid, (phenylamino)-;Anilinoacetic acid;N-(Phenylamino)aceticacid;N-Phenylglycine;NSC 83567; |
| EINECS: | 203-070-2 |
| Density: | 1.259 g/cm3 |
| Melting Point: | 121-127 °C |
| Boiling Point: | 359 °C at 760 mmHg |
| Flash Point: | 170.9 °C |
| Solubility: | moderately soluble in water |
| Appearance: | ochre to yellow-brown fine powder |
| Risk Codes: | 36/37/38 |
| Safety: | 22-24/25 |
| PSA: | 49.33000 |
| LogP: | 1.25610 |

| Conditions | Yield |
|---|---|
| Stage #1: ethyl bromoacetate; aniline With silica gel at 20℃; for 0.116667h; microwave irradiation; Stage #2: With sodium hydroxide In ethanol for 0.166667h; Heating; | 93% |
| Stage #1: ethyl bromoacetate; aniline With potassium carbonate for 1.5h; Milling; Stage #2: With potassium hydroxide for 1.5h; Milling; | 91% |
| Stage #1: ethyl bromoacetate; aniline Stage #2: With sodium hydroxide |

| Conditions | Yield |
|---|---|
| 90% |

tert-butyl 2-(phenylamino)acetate


N-Phenylglycine

| Conditions | Yield |
|---|---|
| With trifluoroacetic acid In dichloromethane for 3h; | 90% |
| In water; isopropyl alcohol at 200℃; for 0.25h; Solvent; Temperature; Flow reactor; | 77% |

| Conditions | Yield |
|---|---|
| With potassium phosphate; copper(l) iodide; 2-(N,N-dimethylamino)ethanol In water at 75 - 80℃; for 72h; | 87% |
| With copper(l) iodide; 2-(2-methyl-1-oxopropyl)cyclohexanone; caesium carbonate In N,N-dimethyl-formamide at 20℃; for 4h; Inert atmosphere; | 82% |
| With copper(I) oxide; caesium carbonate at 100℃; for 0.666667h; Sealed tube; Microwave irradiation; | 10% |

| Conditions | Yield |
|---|---|
| With copper(l) iodide; 2-(2-methyl-1-oxopropyl)cyclohexanone; potassium carbonate In water at 90℃; for 0.833333h; Microwave irradiation; Green chemistry; | 81% |
| With pectin-stabilized copper nanoparticles In dimethyl sulfoxide at 110℃; for 2h; | 71% |
| With potassium phosphate; copper(l) iodide; 2-(N,N-dimethylamino)ethanol In water at 90℃; | 62% |
| With copper(l) iodide; potassium carbonate In N,N-dimethyl acetamide at 90℃; |

| Conditions | Yield |
|---|---|
| With sodium hydroxide In water for 0.5h; Heating; | 73% |
| With sodium hydroxide for 0.5h; Heating; | 70% |
| Stage #1: N-phenylglycine ethyl ester With sodium hydroxide In water for 0.5h; Reflux; Stage #2: With hydrogenchloride In water pH=2; |

1-phenyl-4-oximinoimidazolidine


N-Phenylglycine

| Conditions | Yield |
|---|---|
| With hydrogenchloride Hydrolysis; | 60% |

iodobenzene


glycylglycine

A

N-(N-phenyl-glycyl)-glycine

B

N-Phenylglycine

| Conditions | Yield |
|---|---|
| With potassium phosphate; copper(l) iodide; 2-(N,N-dimethylamino)ethanol In water at 70℃; for 16h; | A 40% B 27% |


| Conditions | Yield |
|---|---|
| With sulfuric acid Electrolysis.elektrolytische Reduktion; |

| Conditions | Yield |
|---|---|
| With potassium cyanide; ethanol |
