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CAS No.: | 107007-99-8 |
---|---|
Name: | Granisetron hydrochloride |
Article Data: | 3 |
Molecular Structure: | |
Formula: | C18H25ClN4O |
Molecular Weight: | 348.876 |
Synonyms: | 1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, monohydrochloride(9CI);BRL 43694A;Kytril;1H-Indazole-3-carboxamide,1-methyl-N-[(3-endo)-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-, hydrochloride(1:1);1H-Indazole-3-carboxamide,1-methyl-N-(9-methyl-9-azabicyclo[3.3.1]non-3-yl)-, monohydrochloride, endo-; |
EINECS: | 634-603-0 |
Density: | 1.33g/cm3 |
Melting Point: | 290-292 °C |
Boiling Point: | 532 °C at 760 mmHg |
Flash Point: | 275.6 °C |
Appearance: | white to off-white crystalline solid |
Hazard Symbols: | Xn,Xi |
Risk Codes: | 22-62-37/38-36/37/38-36 |
Safety: | 26-36-37 |
PSA: | 50.16000 |
LogP: | 3.44920 |
granisetron
granisetron hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In water; isopropyl alcohol | 77% |
With hydrogenchloride In water; toluene at 50 - 60℃; |
endo-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine
1-methylindazole-3-carboxylic acid chloride
granisetron hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; triethylamine In dichloromethane |
granisetron hydrochloride
granisetron
Conditions | Yield |
---|---|
With ammonia; water for 0.5h; Product distribution / selectivity; |
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IUPAC Name: 1-Methyl-N-[(1S,5R)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide hydrochloride
Empirical Formula: C18H25ClN4O
Molecular Weight: 348.8703
Flash Point: 275.6 °C
Enthalpy of Vaporization: 80.77 kJ/mol
Boiling Point: 532 °C at 760 mmHg
Vapour Pressure: 2.12E-11 mmHg at 25 °C
Appearance: White to Off-White Crystalline Solid
Melting Point: 290-292 °C
storage temp.: Room temp
Classification Code of Granisetron hydrochloride (CAS NO.107007-99-8): Anti-emetic; Drug / Therapeutic Agent; Mutation data; Reproductive Effect
Product Categories: Pharmaceutical material and intermeidates; Active Pharmaceutical Ingredients; API; Heterocyclic Compounds; Intermediates & Fine Chemicals; Neurochemicals; Pharmaceuticals; Granisetron; Serotonin receptor; Serotonin
Granisetron hydrochloride (CAS NO.107007-99-8) is used as an antiemetic.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 3mg/kg (3mg/kg) | SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING | Yakkyoku. Pharmacy. Vol. 43, Pg. 589, 1992. |
dog | LDLo | oral | 15mg/kg (15mg/kg) | BEHAVIORAL: TREMOR GASTROINTESTINAL: NAUSEA OR VOMITING | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 37, Pg. 2697, 1995. |
mouse | LD50 | intravenous | 17mg/kg (17mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990. |
mouse | LD50 | oral | 350mg/kg (350mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995. | |
rat | LD50 | intravenous | 14mg/kg (14mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ATAXIA BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 4991, 1990. |
rat | LD50 | oral | 350mg/kg (350mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 26, Pg. 740, 1995. |
Hazard Codes: Xn,Xi
Risk Statements: 22-62-37/38-36/37/38-36
R22:Harmful if swallowed.
R62:Risk of impaired fertility.
R37/38:Irritating to respiratory system and skin.
R36/37/38:Irritating to eyes, respiratory system and skin.
R36:Irritating to eyes.
Safety Statements: 26-36-37
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
S37:Wear suitable gloves.
RTECS: NK7882200
Granisetron hydrochloride (CAS NO.107007-99-8), its Synonyms are 1-Methyl-N-(9-methyl-endo-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide monohydrochloride ; Granisetron HCl ; Granisetron hydrochloride preservative free ; Kytril ; Kytril Injection ; endo-1-Methyl-N-(9-methyl-9-azabicyclo(3.3.1)non-3-yl)-1H-indazole-3-carboxamide hydrochloride .