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CAS No.: | 1103738-29-9 |
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Name: | 4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene |
Article Data: | 15 |
Molecular Structure: | |
Formula: | C15H14ClIO |
Molecular Weight: | 372.633 |
Synonyms: | Benzene, 1-chloro-2-[(4-ethoxyphenyl)methyl]-4-iodo-; 1-Chloro-2-(4-Ethoxybenzyl)-4-Iodobenzene; 4-(5-Iodo-2-chlorobenzyl)phenyl ethyl ether; 4-Iodo-1-chloro-2-(4-ethoxybenzyl)benzene |
Density: | 1.531±0.06 g/cm3(Predicted) |
Boiling Point: | 411.2±40.0 °C(Predicted) |
Appearance: | off-white solid |
PSA: | 9.23000 |
LogP: | 4.93410 |
(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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With triethylsilane; boron trifluoride diethyl etherate In acetonitrile at 5 - 20℃; for 17.5h; | 97.4% |
With triethylsilane; boron trifluoride diethyl etherate In acetonitrile at 5 - 20℃; for 17.508h; Inert atmosphere; | 97.4% |
Stage #1: (2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone With sodium tetrahydroborate In tetrahydrofuran for 0.5h; Inert atmosphere; Stage #2: With aluminum (III) chloride at 10℃; for 0.5h; Reflux; | 91.2% |
2-bromomethyl-1-chloro-4-iodo-benzene
4-bromoethoxybenzene
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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Stage #1: 4-bromoethoxybenzene With iodine; magnesium; methoxybenzene at 47℃; for 3.2h; Stage #2: 2-bromomethyl-1-chloro-4-iodo-benzene With copper(l) iodide at -18 - 20℃; for 16.2h; Temperature; | 95.9% |
2-chloro-5-iodobenzoylchloride
Phenetole
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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Stage #1: 2-chloro-5-iodobenzoylchloride; Phenetole With aluminum (III) chloride In dichloromethane at -5 - 15℃; Stage #2: at 25 - 30℃; for 26h; | 67% |
Stage #1: Phenetole With aluminum (III) chloride In dichloromethane at -3 - 5℃; for 0.5h; Stage #2: 2-chloro-5-iodobenzoylchloride In dichloromethane at 0 - 25℃; for 12h; Stage #3: In dichloromethane at 30℃; for 16h; | 67% |
Stage #1: 2-chloro-5-iodobenzoylchloride; Phenetole With aluminum (III) chloride In dichloromethane at 0 - 5℃; for 2h; Stage #2: In dichloromethane at 25 - 30℃; for 26h; | 67% |
(2-chloro-5-iodo-phenyl)-(4-ethoxyphenyl)methanone
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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With triethylsilane In acetonitrile |
2-chloro-5-iodobenzoylchloride
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 2.33 h / -7 - 9 °C / Inert atmosphere 2: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 17.5 h / 5 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: aluminum (III) chloride / dichloromethane / 0.12 h / -7 - 9 °C / Inert atmosphere 1.2: 2.22 h / 3 - 5 °C 2.1: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 17.5 h / 5 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride / dichloromethane / 2 h / 5 - 15 °C / Industrial scale 2: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 2.5 h / 20 - 30 °C / Industrial scale View Scheme | |
Multi-step reaction with 2 steps 1: aluminum (III) chloride; water / dichloromethane / 2 h / 5 - 15 °C / Industrial scale 2: triethylsilane; boron trifluoride diethyl etherate / acetonitrile / 2.5 h / 20 - 30 °C / Industrial scale View Scheme |
2-chloro-5-iodobenzoic acid
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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Multi-step reaction with 3 steps 1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20.93 h 2: aluminum (III) chloride / dichloromethane / 2.33 h / -7 - 9 °C / Inert atmosphere 3: boron trifluoride diethyl etherate; triethylsilane / acetonitrile / 17.5 h / 5 - 20 °C / Inert atmosphere View Scheme | |
Multi-step reaction with 2 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16 h / 10 - 25 °C 2.1: aluminum (III) chloride / dichloromethane / -5 - 15 °C 2.2: polymethylhydrosiloxane (PMHS) / 26 h / 25 - 30 °C View Scheme | |
Multi-step reaction with 2 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 16.17 h / 10 - 25 °C 2.1: aluminum (III) chloride / dichloromethane / 0.5 h / -3 - 5 °C 2.2: 12 h / 0 - 25 °C 2.3: polymethylhydrosiloxane (PMHS) / 16 h / 30 °C View Scheme |
Phenetole
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: oxalyl chloride / dichloromethane; N,N-dimethyl-formamide / 4 h / 20 °C 1.2: 3 h / 0 - 20 °C 2.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane; acetonitrile / 0 - 20 °C View Scheme |
fluorobenzene
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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Multi-step reaction with 3 steps 1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 39 - 42 °C 1.2: Reflux 2.1: sodium hydroxide / 50 - 65 °C 3.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / Inert atmosphere 3.2: 0.5 h / 10 °C / Reflux View Scheme |
(2-chloro-5-iodophenyl)(4-fluorophenyl)methanone
1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: sodium hydroxide / 50 - 65 °C 2.1: sodium tetrahydroborate / tetrahydrofuran / 0.5 h / Inert atmosphere 2.2: 0.5 h / 10 °C / Reflux View Scheme |
Conditions | Yield |
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Stage #1: 1-chloro-2-(4-ethoxybenzyl)-4-iodobenzene With TurboGrignard In tetrahydrofuran at -5 - 0℃; for 1h; Stage #2: C30H33NO6 In tetrahydrofuran; toluene at -5 - 0℃; | 91% |