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CAS No.: | 462-06-6 |
---|---|
Name: | Fluorobenzene |
Article Data: | 381 |
Molecular Structure: | |
Formula: | C6H5F |
Molecular Weight: | 96.1041 |
Synonyms: | Monofluorobenzene;NSC 68416;Phenyl fluoride;Fluorbenzene; |
EINECS: | 207-321-7 |
Density: | 1.026 g/cm3 |
Melting Point: | -42 °C |
Boiling Point: | 84.7 °C at 760 mmHg |
Flash Point: | -15 °C |
Solubility: | insoluble in water |
Appearance: | Colorless liquid |
Hazard Symbols: | Xi, F, T |
Risk Codes: | 36/37/38-11-39/23/24/25-23/24/25-52/53-36 |
Safety: | 16-26-36-7-33-29-45-36/37-61-7/9 |
Transport Information: | UN 2387 3/PG 2 |
PSA: | 0.00000 |
LogP: | 1.82570 |
copper
A
fluorobenzene
B
iodobenzene
C
biphenyl
D
copper(I) tetrafluoroborate
E
benzene
Conditions | Yield |
---|---|
In acetonitrile Kinetics; stirred at 20-70°C; GLC; | A <1 B 100% C 95% D 99% E 5% |
4-fluorophenyl(m-carboran-9-yl)iodonium tetrafluoroborate
sodium chloride
A
fluorobenzene
B
9-iodo-m-carborane
C
9-chloro-m-carborane
D
4-fluoro-1-iodobenzene
Conditions | Yield |
---|---|
In chloroform; water mixt. of aryl(m-carboran-9-yl)iodonium tetrafluoroborate, NaCl, water and chloroform was vigorously stirred under reflux at 56°C, 2-2.5 h; internal standard (chlorobenzene) added and org. layer was analysed by GLC; | A 0% B 0% C 100% D 100% |
2-(trifluoromethyl)phenylacetic acid
2-(4-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
A
fluorobenzene
Conditions | Yield |
---|---|
With t-Boc-L-valine; 2,5-di-tert-butyl-p-benzoquinone; oxygen; potassium hydrogencarbonate In tert-Amyl alcohol at 90℃; under 2280.15 Torr; for 24h; Catalytic behavior; | A n/a B 99% |
Conditions | Yield |
---|---|
Stage #1: aniline With hydrogen fluoride at -10 - 0.5℃; Flow reactor; Large scale; Stage #2: With nitrosylsulfuric acid at 0 - 10℃; Temperature; Flow reactor; Large scale; | 98.9% |
With pyridine; hydrogen fluoride; sodium nitrite Product distribution; changed molar ratio HF/Pyr, changed time and temperature, only HF; multistep reaction; 1.) 20 deg C, 30 min., 2.) 55 deg C, 1 h; | 95% |
Stage #1: aniline With hydrogenchloride; fluoroboric acid; sodium nitrite In water at 25℃; for 0.00416667h; Balz-Schiemann Reaction; Stage #2: at 125℃; for 0.0166667h; Balz-Schiemann Reaction; | 92% |
2-fluorobenzenediazonium tetrafluoroborate
A
fluorobenzene
B
ortho-difluorobenzene
Conditions | Yield |
---|---|
With boron trifluoride diethyl etherate; hydrogen fluoride at 12℃; for 1h; Decomposition; Fluoro-dediazoniation; Irradiation; | A 0.2% B 98.9% |
With boron trifluoride diethyl etherate at 12℃; for 3h; Decomposition; Fluoro-dediazoniation; Irradiation; | A 10.7% B 84.6% |
Conditions | Yield |
---|---|
With C60H48BP3Pd; potassium formate; [2.2.2]cryptande In tetrahydrofuran at 60℃; for 72h; Schlenk technique; Inert atmosphere; | 97% |
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; cesium fluoride In 2-pentanol at 100℃; for 18h; Inert atmosphere; | A 95.5% B 4.5% |
With palladium; hydroquinone; potassium hydroxide In glycerol at 90℃; for 18h; chemoselective reaction; | A n/a B 71 %Chromat. |
Conditions | Yield |
---|---|
With pyridine; hydrogen fluoride at 55℃; for 1h; Product distribution; Rate constant; Thermodynamic data; changed molar ratio HF/Pyr, temp. and time; energy/enthalpy of activation; | 95% |
With tetrakis(acetonitrile)copper(I)tetrafluoroborate; [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; cesium fluoride In acetone at 30℃; Irradiation; | 37% |
With sodium difluorohydrogenate; 1,2,4-Trichlorobenzene |
Conditions | Yield |
---|---|
With fluorine at 60℃; under 3750.38 Torr; Temperature; | 95% |
With trifluorormethanesulfonic acid; Selectfluor In dichloromethane at 40℃; for 20h; Fluorination; | 83% |
With Al2CuF8 at 500℃; Reagent/catalyst; Inert atmosphere; | 47% |
Conditions | Yield |
---|---|
With formaldehyd; palladium diacetate; caesium carbonate In dimethyl sulfoxide at 80℃; for 12h; | 94% |
With sodium tetrahydroborate; di-tert-butyl peroxide In N,N-dimethyl-formamide at 70℃; for 2h; Irradiation; | 82 % Chromat. |
With hydrogenchloride; CuI*P(Et)3; naphthalen-1-yl-lithium 1.) THF, 25 deg C, 10 min; Yield given. Multistep reaction; |
Product Name:Fluorobenzene(462-06-6)
CAS No:462-06-6
MF: C6H5F
MW: 96.1
mp : -42 °C
bp : 85 °C(lit.)
density : 1.024 g/mL at 25 °C(lit.)
vapor density : 3.31 (vs air)
refractive index : n20/D 1.465(lit.)
Fp : 9 °F
storage temp. : 0-6°C
Water Solubility : Insoluble
Synonyms: benzene,benzene,fluoro-;fluoro-benzen;Fluorobenzenes;Fluorylfluoride;Monofluorobenzene;Phenyl fluoride;Phenylfluoride;FLUOROBENZENE
Molecular Structure:
General Description of Fluorobenzene(462-06-6): A clear, colorless liquid with a characteristic aromatic odor. About the same density as water. Flash point 5°F. Vapors heavier than air. May irritate the skin, eyes, and mucous membranes. Used as an insecticide, larvacide and as a reagent for plastic or resin polymers.
On the laboratory scale, PhF is conveniently prepared by the thermal decomposition of the phenyldiazonium tetrafluoroborate:
PhN2BF4 → PhF + BF3 + N2
According to the procedure, solid [PhN2]BF4 is heated with a flame to initiate an exothermic reaction that affords two volatile products, PhF and BF3, which are readily separated because of their differing boiling points.PhF was first reported in 1886 by O. Wallach at the University of Bonn, who prepared the compound in two steps, starting also with a phenyldiazonium salt. The diazonium chloride was first converted to its piperidinide, which in turn was cleaved using hydrofluoric acid.
[PhN2]Cl + 2 C5H10NH → PhN=N-NC5H10 + [C5H10NH2]Cl
PhN=N-NC5H10 + 2 HF → PhF + N2 + [C5H10NH2]F
An interesting historical note: in Wallach’s era, the element fluorine was symbolized with “Fl”. Thus, his procedure is subtitled “Fluorbenzol(462-06-6), C6H5Fl”.The technical synthesis is by the reaction of cyclopentadiene with difluorocarbene. The initially formed cyclopropane undergoes a ring expansion and subsequent elimination of hydrogen fluoride.