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CAS No.: | 113994-41-5 |
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Name: | Dehydro Amlodipine (Amlodipine Impurity D) |
Article Data: | 13 |
Molecular Structure: | |
Formula: | C20H23 Cl N2 O5 |
Molecular Weight: | 406.866 |
Synonyms: | 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester;3-Ethyl 5-Methyl Ester 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methylpyridine-3,5-dicarboxylate;Amlodipine Impurity D;Dehydro Amlodipine (Amlodipine Impurity D);2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-3,5-pyridinedicarboxylic Acid 3-Ethyl 5-Methyl Ester Oxalate;Dehydro Amlodipine Oxalate |
Density: | 1.241±0.06 g/cm3(Predicted) |
Melting Point: | 106-108°C |
Boiling Point: | 517.9±50.0 °C(Predicted) |
PSA: | 100.74000 |
LogP: | 3.84930 |
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Conditions | Yield |
---|---|
With hydrazine hydrate In ethanol at 20℃; for 20h; | 98% |
With hydrazine In methanol; toluene at 20℃; for 4h; | 61% |
(R)-2-[(2-aminoethoxy)methyl]4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Conditions | Yield |
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With calcium hypochlorite In water; ethyl acetate at 20 - 30℃; Reagent/catalyst; Temperature; Solvent; | 93.4% |
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Conditions | Yield |
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Stage #1: 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine With hydrogenchloride In water Stage #2: With nickel In water at 20℃; for 6h; | 73.2% |
With potassium permanganate In 1,4-dioxane; water for 16h; Ambient temperature; | |
With potassium superoxide In dimethyl sulfoxide at 37℃; for 5h; Kinetics; |
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Conditions | Yield |
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With Britton-Robinson buffer In water; N,N-dimethyl-formamide at 37℃; pH=7.4; Kinetics; |
4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-2-[2-phthalimidoethoxymethyl]-1,4-dihydropyridine
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 97 percent / Pb(OAc)4 / CH2Cl2; acetic acid / 19 h / 20 °C 2: 98 percent / hydrazine monohydrate / aq. ethanol / 20 h / 20 °C View Scheme |
amlodipine
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Conditions | Yield |
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With human P450 enzyme CYP3A4; NADPH In aq. phosphate buffer for 0.216667h; pH=7.4; Enzymatic reaction; |
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
C
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Conditions | Yield |
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With sodium hypochlorite; octabromotetrakis(2,6-dichlorophenyl)porphyrin Fe(III)Cl; water In acetonitrile at 80℃; for 0.166667h; Microwave irradiation; |
2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine
I
4-(2-Chloro-phenyl)-2,6-dimethyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
J
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Conditions | Yield |
---|---|
In water at 10℃; Irradiation; |
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
L-Pyroglutamic acid
Conditions | Yield |
---|---|
In ethyl acetate at 25℃; for 1h; | 95.3% |
In ethyl acetate at 25℃; for 1h; | 95.3% |
2-(2-Amino-ethoxymethyl)-4-(2-chloro-phenyl)-6-methyl-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester
Pyroglutamic acid
Conditions | Yield |
---|---|
95.2% |