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CAS No.: | 1147103-42-1 |
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Name: | (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C10H17NO2.HCl |
Molecular Weight: | 219.711 |
Synonyms: | (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-car; |
PSA: | 38.33000 |
LogP: | 2.06840 |
(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid
ethanol
C10H17NO2*ClH
Conditions | Yield |
---|---|
With thionyl chloride for 2h; Reflux; | 71% |
(1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester
C10H17NO2*ClH
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 30 - 35℃; for 4h; Inert atmosphere; Cooling with ice; | 70% |
C10H17NO2*ClH
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: ethyl acetate / 12 h / 20 °C 2: sodium hydrogen sulfate / tert-butyl methyl ether; water 3: thionyl chloride / 2 h / Reflux View Scheme |
C10H17NO2*ClH
Conditions | Yield |
---|---|
Multi-step reaction with 7 steps 1: sodium hydrogensulfite / tert-butyl methyl ether; water / 2 h / 20 °C 2: 3 h / 10 °C / pH 9 3: hydrogenchloride / water; dichloromethane / 1 h 4: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8 5: ethyl acetate / 12 h / 20 °C 6: sodium hydrogen sulfate / tert-butyl methyl ether; water 7: thionyl chloride / 2 h / Reflux View Scheme |
(3aR,6aS)-octahydrocyclopenta[c]pyrrole hydrochloride
C10H17NO2*ClH
Conditions | Yield |
---|---|
Multi-step reaction with 8 steps 1: sodium hypochlorite solution / tert-butyl methyl ether / 2 h / 15 °C 2: sodium hydrogensulfite / tert-butyl methyl ether; water / 2 h / 20 °C 3: 3 h / 10 °C / pH 9 4: hydrogenchloride / water; dichloromethane / 1 h 5: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8 6: ethyl acetate / 12 h / 20 °C 7: sodium hydrogen sulfate / tert-butyl methyl ether; water 8: thionyl chloride / 2 h / Reflux View Scheme |
C10H17NO2*ClH
Conditions | Yield |
---|---|
Multi-step reaction with 6 steps 1: 3 h / 10 °C / pH 9 2: hydrogenchloride / water; dichloromethane / 1 h 3: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8 4: ethyl acetate / 12 h / 20 °C 5: sodium hydrogen sulfate / tert-butyl methyl ether; water 6: thionyl chloride / 2 h / Reflux View Scheme |
C10H17NO2*ClH
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: hydrogenchloride / water; dichloromethane / 1 h 2: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8 3: ethyl acetate / 12 h / 20 °C 4: sodium hydrogen sulfate / tert-butyl methyl ether; water 5: thionyl chloride / 2 h / Reflux View Scheme |
C10H17NO2*ClH
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8 2: ethyl acetate / 12 h / 20 °C 3: sodium hydrogen sulfate / tert-butyl methyl ether; water 4: thionyl chloride / 2 h / Reflux View Scheme |
(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid
ethanol
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
Conditions | Yield |
---|---|
With thionyl chloride for 2h; Reflux; | 71% |
(1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride In ethyl acetate at 30 - 35℃; for 4h; Inert atmosphere; Cooling with ice; | 70% |