Welcome to LookChem.com Sign In|Join Free

CAS

  • or

1147103-42-1

(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride is a complex organic chemical compound characterized by its specific stereochemistry, as indicated by the 1S, 3aR, 6aS designation. (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride features an octahydrocyclopenta[c]pyrrole group, which is a ring structure composed of five carbon atoms and a nitrogen atom. Additionally, it contains a 1-carboxylic acid ethyl ester functional group, with an ethyl ester attached at the first position of the ring. The hydrochloride suffix in its name signifies that it is a salt formed with hydrochloric acid. However, the specific chemical properties, uses, or synthesis methods of this compound are not detailed in the name itself.
Usage:
Since the provided materials do not specify the uses of (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride, it is not possible to list its applications based on the given information. However, given its complex structure and functional groups, it may potentially be used in various industries such as pharmaceuticals, materials science, or chemical research, depending on its properties and reactivity. Further information would be required to determine its specific applications and reasons for use in different industries.

1147103-42-1 Suppliers

Post Buying Request

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

  • High quality cyclopenta[c]pyrrole-1-carboxylic acid, octahydro-, ethyl ester, (1s,3ar,6as)-? supplier in China

    Cas No: 1147103-42-1

  • No Data

  • 1 Metric Ton

  • 30 Metric Ton/Month

  • Simagchem Corporation
  • Contact Supplier

  • (1S,3αR,6αS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride

    Cas No: 1147103-42-1

  • USD $ 1.2-5.0 / Kiloliter

  • 5 Kiloliter

  • 3000 Metric Ton/Month

  • Chemwill Asia Co., Ltd.
  • Contact Supplier
  • 1147103-42-1 Structure

  • Basic information

    1. Product Name: (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride
    2. Synonyms: (1S,3aR,6aS)-octahydro-, Cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester HCl;(1S,3aR,6aS)-ethyloctahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride;Cyclopenta[c]pyrrole-1-carboxylic acid, octahydro-, ethyl ester, hydrochloride (1:1), (1S,3aR,6aS)-;CYCLOPENTA(C)PYRROLE-1-CARBOXYLIC ACID,OCTAHYDRO-ETHYL ESTERHYDROCHLORIDE;(1S,3R,6S)-Ethyl Octahydrocyclopenta[c] pyrrole-1-carboxylate HCL;Cyclopenta[c]pyrrole-1-carboxylic acid, octahydro-, ethyl ester, (1S,3aR,6aS)-, hydrochloride;Telaprevir INT2;(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride
    3. CAS NO:1147103-42-1
    4. Molecular Formula: C10H17NO2*ClH
    5. Molecular Weight: 219.70842
    6. EINECS: N/A
    7. Product Categories: Telaprevir intermediate
    8. Mol File: 1147103-42-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride(CAS DataBase Reference)
    10. NIST Chemistry Reference: (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride(1147103-42-1)
    11. EPA Substance Registry System: (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride(1147103-42-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1147103-42-1(Hazardous Substances Data)

1147103-42-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1147103-42-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,7,1,0 and 3 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1147103-42:
(9*1)+(8*1)+(7*4)+(6*7)+(5*1)+(4*0)+(3*3)+(2*4)+(1*2)=111
111 % 10 = 1
So 1147103-42-1 is a valid CAS Registry Number.

1147103-42-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name ethyl (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1147103-42-1 SDS

1147103-42-1Synthetic route

(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid
597569-42-1

(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid

ethanol
64-17-5

ethanol

C10H17NO2*ClH
1147103-42-1

C10H17NO2*ClH

Conditions
ConditionsYield
With thionyl chloride for 2h; Reflux;71%
(1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester
1053232-60-2

(1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester

C10H17NO2*ClH
1147103-42-1

C10H17NO2*ClH

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 30 - 35℃; for 4h; Inert atmosphere; Cooling with ice;70%
(3aR,6aS)-2-Boc-octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(3aR,6aS)-2-Boc-octahydrocyclopenta[c]pyrrole-1-carboxylic acid

C10H17NO2*ClH
1147103-42-1

C10H17NO2*ClH

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethyl acetate / 12 h / 20 °C
2: sodium hydrogen sulfate / tert-butyl methyl ether; water
3: thionyl chloride / 2 h / Reflux
View Scheme
(3aR,6aS)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole

(3aR,6aS)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole

C10H17NO2*ClH
1147103-42-1

C10H17NO2*ClH

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: sodium hydrogensulfite / tert-butyl methyl ether; water / 2 h / 20 °C
2: 3 h / 10 °C / pH 9
3: hydrogenchloride / water; dichloromethane / 1 h
4: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
5: ethyl acetate / 12 h / 20 °C
6: sodium hydrogen sulfate / tert-butyl methyl ether; water
7: thionyl chloride / 2 h / Reflux
View Scheme
(3aR,6aS)-octahydrocyclopenta[c]pyrrole hydrochloride
112626-50-3

(3aR,6aS)-octahydrocyclopenta[c]pyrrole hydrochloride

C10H17NO2*ClH
1147103-42-1

C10H17NO2*ClH

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: sodium hypochlorite solution / tert-butyl methyl ether / 2 h / 15 °C
2: sodium hydrogensulfite / tert-butyl methyl ether; water / 2 h / 20 °C
3: 3 h / 10 °C / pH 9
4: hydrogenchloride / water; dichloromethane / 1 h
5: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
6: ethyl acetate / 12 h / 20 °C
7: sodium hydrogen sulfate / tert-butyl methyl ether; water
8: thionyl chloride / 2 h / Reflux
View Scheme
sodium (3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-sulfonate

sodium (3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-sulfonate

C10H17NO2*ClH
1147103-42-1

C10H17NO2*ClH

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 3 h / 10 °C / pH 9
2: hydrogenchloride / water; dichloromethane / 1 h
3: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
4: ethyl acetate / 12 h / 20 °C
5: sodium hydrogen sulfate / tert-butyl methyl ether; water
6: thionyl chloride / 2 h / Reflux
View Scheme
(3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-cyanide

(3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-cyanide

C10H17NO2*ClH
1147103-42-1

C10H17NO2*ClH

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / water; dichloromethane / 1 h
2: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
3: ethyl acetate / 12 h / 20 °C
4: sodium hydrogen sulfate / tert-butyl methyl ether; water
5: thionyl chloride / 2 h / Reflux
View Scheme
(3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid

C10H17NO2*ClH
1147103-42-1

C10H17NO2*ClH

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
2: ethyl acetate / 12 h / 20 °C
3: sodium hydrogen sulfate / tert-butyl methyl ether; water
4: thionyl chloride / 2 h / Reflux
View Scheme
(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid
597569-42-1

(1S,3aR,6aS)-2-(tert-butoxycarbonyl)octahydrocyclo-penta[c]pyrrole-1-carboxylic acid

ethanol
64-17-5

ethanol

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
With thionyl chloride for 2h; Reflux;71%
(1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester
1053232-60-2

(1S,3aR,6aS)-hexahydro-cyclopenta[c]pyrrole-1,2-dicarboxylic acid 2-tert-butyl ester ethyl ester

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
With hydrogenchloride In ethyl acetate at 30 - 35℃; for 4h; Inert atmosphere; Cooling with ice;70%
(3aR,6aS)-2-Boc-octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(3aR,6aS)-2-Boc-octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: ethyl acetate / 12 h / 20 °C
2: sodium hydrogen sulfate / tert-butyl methyl ether; water
3: thionyl chloride / 2 h / Reflux
View Scheme
(3aR,6aS)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole

(3aR,6aS)-1,3a,4,5,6,6a-hexahydrocyclopenta[c]pyrrole

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: sodium hydrogensulfite / tert-butyl methyl ether; water / 2 h / 20 °C
2: 3 h / 10 °C / pH 9
3: hydrogenchloride / water; dichloromethane / 1 h
4: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
5: ethyl acetate / 12 h / 20 °C
6: sodium hydrogen sulfate / tert-butyl methyl ether; water
7: thionyl chloride / 2 h / Reflux
View Scheme
(3aR,6aS)-octahydrocyclopenta[c]pyrrole hydrochloride
112626-50-3

(3aR,6aS)-octahydrocyclopenta[c]pyrrole hydrochloride

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: sodium hypochlorite solution / tert-butyl methyl ether / 2 h / 15 °C
2: sodium hydrogensulfite / tert-butyl methyl ether; water / 2 h / 20 °C
3: 3 h / 10 °C / pH 9
4: hydrogenchloride / water; dichloromethane / 1 h
5: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
6: ethyl acetate / 12 h / 20 °C
7: sodium hydrogen sulfate / tert-butyl methyl ether; water
8: thionyl chloride / 2 h / Reflux
View Scheme
sodium (3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-sulfonate

sodium (3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-sulfonate

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 3 h / 10 °C / pH 9
2: hydrogenchloride / water; dichloromethane / 1 h
3: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
4: ethyl acetate / 12 h / 20 °C
5: sodium hydrogen sulfate / tert-butyl methyl ether; water
6: thionyl chloride / 2 h / Reflux
View Scheme
(3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-cyanide

(3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-cyanide

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: hydrogenchloride / water; dichloromethane / 1 h
2: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
3: ethyl acetate / 12 h / 20 °C
4: sodium hydrogen sulfate / tert-butyl methyl ether; water
5: thionyl chloride / 2 h / Reflux
View Scheme
(3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylic acid

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: sodium hydroxide / dichloromethane / 10 - 20 °C / pH 8
2: ethyl acetate / 12 h / 20 °C
3: sodium hydrogen sulfate / tert-butyl methyl ether; water
4: thionyl chloride / 2 h / Reflux
View Scheme
(1S,3aR,6aS)-ethyl 2-boc-4-oxooctahydrocyclopenta[c]pyrrole-1-carboxylate
402958-16-1

(1S,3aR,6aS)-ethyl 2-boc-4-oxooctahydrocyclopenta[c]pyrrole-1-carboxylate

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ethanol / 3 h / Reflux
2: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
3: sodium acetate / ethanol / 5 h / Reflux
4: hydrogenchloride / ethyl acetate / 4 h / 30 - 35 °C / Inert atmosphere; Cooling with ice
View Scheme
C22H31N3O6S

C22H31N3O6S

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
2: sodium acetate / ethanol / 5 h / Reflux
3: hydrogenchloride / ethyl acetate / 4 h / 30 - 35 °C / Inert atmosphere; Cooling with ice
View Scheme
C22H33N3O6S

C22H33N3O6S

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium acetate / ethanol / 5 h / Reflux
2: hydrogenchloride / ethyl acetate / 4 h / 30 - 35 °C / Inert atmosphere; Cooling with ice
View Scheme
3-Ethoxycarbonylmethyl-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium; bromide
103871-46-1

3-Ethoxycarbonylmethyl-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium; bromide

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / water; N,N-dimethyl-formamide / 16 h / 0 - 20 °C
2.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 8 h / 70 - 75 °C / Inert atmosphere
2.2: 8 h / 0 - 20 °C
3.1: ethanol / 3 h / Reflux
4.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
5.1: sodium acetate / ethanol / 5 h / Reflux
6.1: hydrogenchloride / ethyl acetate / 4 h / 30 - 35 °C / Inert atmosphere; Cooling with ice
View Scheme
C15H21NO4S

C15H21NO4S

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride / toluene / 8 h / 70 - 75 °C / Inert atmosphere
1.2: 8 h / 0 - 20 °C
2.1: ethanol / 3 h / Reflux
3.1: sodium tetrahydroborate; methanol / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
4.1: sodium acetate / ethanol / 5 h / Reflux
5.1: hydrogenchloride / ethyl acetate / 4 h / 30 - 35 °C / Inert atmosphere; Cooling with ice
View Scheme
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid
402958-98-9

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: diisopropyl-carbodiimide; 4-methyl-morpholine; copper dichloride / N,N-dimethyl-formamide / 5 h / 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
View Scheme
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide

(1S,3aR,6aS)-2-[(2S)-2-[[(2S)-2-cyclohexyl-2-[(2-pyrazinylcarbonyl)amino] acetyl]amino]-3,3-dimethylbutanoyl]-N-[(1S)-1-[(cyclopropylamino)(hydroxy)acetyl]butyl]-3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrole-3-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: diisopropyl-carbodiimide; 4-methyl-morpholine; copper dichloride / N,N-dimethyl-formamide / 5 h / 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
View Scheme
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide
402957-28-2

(1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)octahydrocyclopenta[c]pyrrole-1-carboxamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: diisopropyl-carbodiimide; 4-methyl-morpholine; copper dichloride / N,N-dimethyl-formamide / 5 h / 20 °C
2: sodium hydroxide; water / tetrahydrofuran / 18 h / 20 °C
3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 6 h / 20 °C / Cooling with ice
4: sodium hydrogencarbonate; potassium bromide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hypochlorite / dichloromethane / 20 h / 20 °C / Cooling with ice
View Scheme
(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride
1147103-42-1

(1S,3aR,6aS)-ethyl octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride

(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid
402958-96-7

(S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoic acid

(1S,3aR,6aS)-ethyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate
402958-97-8

(1S,3aR,6aS)-ethyl 2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-2-carboxamido)acetamido)-3,3-dimethylbutanoyl)octahydrocyclopenta[c]pyrrole-1-carboxylate

Conditions
ConditionsYield
With 4-methyl-morpholine; copper dichloride; diisopropyl-carbodiimide In N,N-dimethyl-formamide at 20℃; for 5h;98.1 mg

1147103-42-1Relevant articles and documents

Telaprevir intermediate preparation method

-

, (2017/08/31)

The invention discloses a telaprevir intermediate preparation method. A telaprevir intermediate is a formula I compound, and a reaction route is as shown in the specification, wherein R is selected from C1-C4 alkyl groups, R1 is selected from hydrogen, C1-C8 alkyl groups, C1-C8 alkoxy groups, C6-C12 aryl groups, alkyl sulfonyl, C6-C12 aryl sulfonyl groups or substituted C6-C12 aryl sulfonyl groups, and P is an amino protection group. The method has advantages of simplicity in operation, safety, freeness of pollution and special requirements on equipment, low production cost, high yield and the like, is suitable for large-scale production and has a high practical value in realization of telaprevir industrialization.

A process for the preparation of intermediates telaprevir

-

, (2017/03/14)

The invention provides a telaprevir intermediate preparation method. The telaprevir intermediate preparation method comprises the following steps: (1) synthesizing (3aR, 6aS)-1,3a,4,5,6,6a-hexahydrocyclopentapyrrol; (2) synthesizing (3aR, 6aS)-octahydrocyclopentapyrrol-1-sodium sulfate; (3) synthesizing (3aR, 6aS)- octahydrocyclopentapyrrol-1-cyanogen; (4) synthesizing (3aR, 6aS)- octahydrocyclopentapyrrol-1-carboxylic acid; (5) synthesizing (3aR, 6aS)-2-Boc octahydrocyclopentapyrrol-1-carboxylic acid; (6) synthesizing (1s, 3aR, 6aS)-2-Boc octahydrocyclopentapyrrol-1-carboxylic acid; (7) synthesizing (1s, 3aR, 6aS)-2-Boc octahydrocyclopentapyrrol-1-carboxylic acid ethyl ester salt. The telaprevir intermediate preparation method is reasonable in process, low in cost and simple and convenient to operate, reagents are inexpensive and easy to obtain, and the control on reaction is easy.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 1147103-42-1