CAS No.121-25-5,Amprolium Suppliers

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Basic Information

Molecular Structure:
CAS No.:	121-25-5
Name:	Amprolium

Formula:	C₁₄H₁₉ClN₄
Molecular Weight:	278.78
Synonyms:	Amprolsol;Amprovine;Anticoccid;1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-picoliniumchloride (6CI);2-Picolinium, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-,chloride (8CI);Pyridinium,1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-, chloride (9CI);Ampisol;Amprolium chloride;Amprolium plus;
EINECS:	204-458-4
Melting Point:	246-248 °C (decomp)
Appearance:	solid
Hazard Symbols:	Xn,C,Xi
Risk Codes:	R22; R36/37/38; R34
PSA:	55.68000
LogP:	-0.75930

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Chemistry

Molecular Structure of Amprolium (CAS NO: 121-25-5):

Molecular Formula: C₁₄H₁₉ClN₄
Molecular Weight: 278.7805
IUPAC Name: 5-[(2-Methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride
Synonyms of Amprolium (CAS NO: 121-25-5): 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride ; 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride ; 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride ; 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride monohydrochloride ; Amprol, Veterinary ; Amprolio ; Amprolio [INN-Spanish] ; Amprolium [INN-Latin] ; Amprovine ; EINECS 204-458-4 ; 2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride ; Pyridinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, chloride
CAS NO: 121-25-5
Classification Code: Coccidiostat [for poultry]
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 4
Polar Surface Area: 32.9 Å²
Storage temp.: 0-6°C
Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.

Uses

Amprolium (CAS NO.121-25-5) is used as a coccidiostat.

Toxicity Data With Reference

May cause Thiamine deficiency if given at high rates.

Specification

Mode of action: thiamine analog, competitively inhibits the active transport of thiamine. The coccidia are 50 times as sensitive to this inhibition as is the host.
Pharmacokinetics: Freely soluble in water.
Dose:
In dogs and cats: "extra label use": 300 to 400 mg/kg, SID for 5 days or 110 to 220 mg/kg SID for 7 to 12 days.
In chickens: For prevention of coccidiosis: 36.3 - 113.5 g/ton in the feed or in the drinking water at 0.012%. No withdrawal is needed.