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| CAS No.: | 121-25-5 |
|---|---|
| Name: | Amprolium |
| Molecular Structure: | |
|
|
|
| Formula: | C14H19ClN4 |
| Molecular Weight: | 278.78 |
| Synonyms: | Amprolsol;Amprovine;Anticoccid;1-[(4-Amino-2-propyl-5-pyrimidinyl)methyl]-2-picoliniumchloride (6CI);2-Picolinium, 1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-,chloride (8CI);Pyridinium,1-[(4-amino-2-propyl-5-pyrimidinyl)methyl]-2-methyl-, chloride (9CI);Ampisol;Amprolium chloride;Amprolium plus; |
| EINECS: | 204-458-4 |
| Melting Point: | 246-248 °C (decomp) |
| Appearance: | solid |
| Hazard Symbols: |
 Xn, C, Xi
|
| Risk Codes: | R22; R36/37/38; R34 |
| PSA: | 55.68000 |
| LogP: | -0.75930 |
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Chemistry
Molecular Structure of Amprolium (CAS NO: 121-25-5):
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Molecular Formula: C14H19ClN4
Molecular Weight: 278.7805
IUPAC Name: 5-[(2-Methylpyridin-1-ium-1-yl)methyl]-2-propylpyrimidin-4-amine chloride
Synonyms of Amprolium (CAS NO: 121-25-5): 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride ; 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-methylpyridinium chloride monohydrochloride ; 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride ; 1-((4-Amino-2-propyl-5-pyrimidinyl)methyl)-2-picolinium chloride monohydrochloride ; Amprol, Veterinary ; Amprolio ; Amprolio [INN-Spanish] ; Amprolium [INN-Latin] ; Amprovine ; EINECS 204-458-4 ; 2-Picolinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-, chloride ; Pyridinium, 1-((4-amino-2-propyl-5-pyrimidinyl)methyl)-2-methyl-, chloride
CAS NO: 121-25-5
Classification Code: Coccidiostat [for poultry]
H bond acceptors: 4
H bond donors: 2
Freely Rotating Bonds: 4
Polar Surface Area: 32.9 Å2
Storage temp.: 0-6°C
Stability: Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
Uses
Amprolium (CAS NO.121-25-5) is used as a coccidiostat.
Toxicity Data With Reference
May cause Thiamine deficiency if given at high rates.
Specification
Mode of action: thiamine analog, competitively inhibits the active transport of thiamine. The coccidia are 50 times as sensitive to this inhibition as is the host.
Pharmacokinetics: Freely soluble in water.
Dose:
In dogs and cats: "extra label use": 300 to 400 mg/kg, SID for 5 days or 110 to 220 mg/kg SID for 7 to 12 days.
In chickens: For prevention of coccidiosis: 36.3 - 113.5 g/ton in the feed or in the drinking water at 0.012%. No withdrawal is needed.