CAS No.125238-99-5,FMOC-DAB(BOC)-OH Suppliers

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Basic Information

Molecular Structure:
CAS No.:	125238-99-5
Name:	FMOC-DAB(BOC)-OH
Article Data:	4

Formula:	C₂₄H₂₈N₂O₆
Molecular Weight:	440.496
Synonyms:	Butanoicacid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-,(S)-;(S)-2-[[(9-Fluorenylmethoxy)carbonyl]amino]-4-(tert-butoxycarbonylamino)butanoicacid;(S)-4-[(tert-Butoxycarbonyl)amino]-2-[[[(9H-fluoren-9-yl)methoxy]carbonyl]amino]butanoicacid;
EINECS:	1533716-785-6
Density:	1.243 g/cm³
Melting Point:	111-113℃
Boiling Point:	670.9 °C at 760 mmHg
Flash Point:	359.6 °C
Solubility:	Slightly soluble in water.
Hazard Symbols:	Xi
PSA:	113.96000
LogP:	4.67490

Synthetic route

: 24424-99-5
di-tert-butyl dicarbonate

: 161420-87-7
Nα-(9-fluorenylmethoxycarbonyl)-L-2,4-diaminobutyric acid

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Conditions

Conditions	Yield
With sodium hydroxide In water; acetone at 0 - 10℃; for 4h; pH=7.5 - 8; pH-value;	86.62%
With triethylamine In water; dimethyl sulfoxide	74.2%
With sodium hydrogencarbonate In water; acetonitrile for 6h; Yield given;

: (S)-(3-fluoren-9-yl-9-methoxycarbonyl)-4-[2-(tert-butyloxycarbonylamino)ethyl]-5-oxazolidinone

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Conditions

Conditions	Yield
With lithium hydroxide In tetrahydrofuran at 20℃;	73%

: 918428-66-7
9H-9-fluorenylmethyl (4S)-4-(3-azido-2-oxopropyl)-5-oxo-1,3-oxazolone-3-carboxylate

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 88 percent / toluene / 0.25 h / microwave irradiation 2: 73 percent / LiOH / tetrahydrofuran / 20 °C View Scheme

: 159530-17-3
Nα-Fmoc-Glu-5-oxazolidinone

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 94 percent / N-methylmorpholine; IBC-Cl; NaN3 / tetrahydrofuran / 0.5 h / -10 °C 2: 88 percent / toluene / 0.25 h / microwave irradiation 3: 73 percent / LiOH / tetrahydrofuran / 20 °C View Scheme

: 71989-20-3
N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine

Fmoc-Ala: Fmoc-Ala

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 88.9 percent / I,I-bis(trifluoroacetoxy)iodobenzene; H2O / dimethylsulfoxide / 20 h 2: 74.2 percent / triethylamine / H2O; dimethylsulfoxide View Scheme

: 71989-20-3
N2-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-glutamine

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: pyridine; bis-[(trifluoroacetoxy)iodo]benzene / 1.) CH3CN, H2O, 60 deg C, 2.) CH3CN, H2O, 60 deg C, 5 h 2: sodium hydrogencarbonate / water; acetonitrile / 6 h View Scheme

: 186581-53-3, 908094-01-9
diazomethane

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

: 125218-68-0
Fmoc-L-Dbu(Boc)-OCH3

Conditions

Conditions	Yield
In diethyl ether for 0.166667h; Methylation;	100%

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

: 100-46-9
benzylamine

: 316152-95-1
(9H-fluoren-9-yl)methyl tert-butyl (4-(benzylamino)-4-oxobutane-1,3-diyl)(S)-dicarbamate

Conditions

Conditions	Yield
With benzotriazol-1-ol; diisopropyl-carbodiimide In DMF (N,N-dimethyl-formamide); dichloromethane at 35℃;	100%
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane for 2h; Inert atmosphere;	98%
Stage #1: (S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid With benzotriazol-1-ol; diisopropyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide for 0.0833333h; Stage #2: benzylamine In dichloromethane; N,N-dimethyl-formamide at 35℃;	98%
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In acetonitrile at 20℃; for 3h;	14.4 g
With benzotriazol-1-ol; dicyclohexyl-carbodiimide In acetonitrile at 20℃; for 2.5h;

: 65864-22-4
(S)-2-amino-3-phenylpropionamide hydrochloride

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

: 849948-77-2
(1'S, 2S)-4-(N-Boc-amino)-N'-(1'-carbamoyl-2'-phenylethyl)-2-(N''-Fmoc-amino)butanamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide In DMF (N,N-dimethyl-formamide); dichloromethane	100%
With benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide In dichloromethane; N,N-dimethyl-formamide for 16h;

: 125238-99-5
(S)-4-tert-butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)butyric acid

: 13078-79-0
2-(3-chlorophenyl)ethylamine

: 849948-71-6
4-(N-Boc-amino)-N'-2-(3-chlorophenyl)ethyl-(S)-2-(N''-Fmoc-amino)butanamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; diisopropyl-carbodiimide In DMF (N,N-dimethyl-formamide); dichloromethane at 35℃;	100%

Raw Materials

161420-87-7

24424-99-5

71989-20-3

Total:105 Page 1 of 3 1 2 3 Next>>

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Chemistry

Product Name: N-Fmoc-N'-Boc-L-2,4-diaminobutyric acid
Molecular Structure:

Molecular Formula: C₂₄H₂₈N₂O₆
Molecular Weight: 440.4889
Synonyms of N-Fmoc-N'-Boc-L-2,4-diaminobutyric acid (CAS NO.125238-99-5): Rarechem em wb 0101 ; N-2-(9-fluorenylmethoxycarbonyl)-n-4-t-butoxycarbonyl-l-2,4-diaminobutyric acid ; Nalpha-fmoc-ngamma-boc-l-2,4-diaminobutyric acid ; N-Alpha-fmoc-n-gamma-boc-l-diaminobutyric acid ; N-Alpha-fmoc-n-gamma-t-boc-l-alpha,gamma-diaminobutyric acid ; N-Alpha-fmoc-n-gamma-t-boc-l-diaminobutanoic acid ; N-Alpha-fmoc-n-gamma-t-butyloxycarbonyl-(s)-2,4-diaminobutyric acid ; N-Alpha-(9-fluorenylmethyloxycarbonyl)-n-gamma-t-butyloxycarbonyl-l-2,4-diaminobutyric acid
CAS NO: 125238-99-5
Classification Code: Unusual amino acids ; Amino Acids ; amino acid
Index of Refraction: 1.575
Molar Refractivity: 117.04 cm³
Molar Volume: 354.1 cm³
Surface Tension: 51.4 dyne/cm
Density: 1.243 g/cm³
Flash Point: 359.6 °C
Enthalpy of Vaporization: 103.56 kJ/mol
Boiling Point: 670.9 °C at 760 mmHg
Vapour Pressure of N-Fmoc-N'-Boc-L-2,4-diaminobutyric acid (CAS NO.125238-99-5): 6.47E-19 mmHg at 25°C

Safety Profile

Hazard Codes of N-Fmoc-N'-Boc-L-2,4-diaminobutyric acid (CAS NO.125238-99-5): Xi
WGK Germany: 3
F: 10
HazardClass: IRRITANT