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CAS No.: | 125323-99-1 |
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Name: | BOC-LYS(Z)(ISOPROPYL)-OH |
Molecular Structure: | |
Formula: | C22H34 N2 O6 |
Molecular Weight: | 422.522 |
Synonyms: | t-Boc-Met-Leu-Phe-OH;Boc-Met-Leu-Phe;t-butyloxycarbonyl-methionyl-leucyl-phenylalanine;Boc-MLF,Boc-1;Boc-Met-Leu-Pje-OH;Boc-L-Met-L-Leu-L-Phe-OH;tert-butoxycarbonyl-Met-Leu-Phe peptide;N-T-BOC-MET-LEU-PHE;tert-butyloxycarbonyl-methionyl-leucyl-phenylalanine; |
Density: | 1.136±0.06 g/cm3(Predicted) |
Boiling Point: | 580.3±50.0 °C(Predicted) |
PSA: | 117.20000 |
LogP: | 8.20500 |
Nα-tert-butyloxycarbonyl-Nε-isopropyl-L-lysine
benzyl chloroformate
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
Conditions | Yield |
---|---|
With sodium hydroxide Ambient temperature; Yield given; |
1-(tert-butoxycarbonyl)-L-proline
N-tert-butoxycarbonyl-L-leucine
acetic anhydride
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
(R)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
Multistep reaction; | 42 mg |
N-tert-butoxycarbonyl-L-leucine
Boc-(R)-Ala
BOC-O-benzyl-L-serine
acetic anhydride
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
Conditions | Yield |
---|---|
Multistep reaction.; |
1-(tert-butoxycarbonyl)-L-proline
N-tert-butoxycarbonyl-L-leucine
Boc-(R)-Ala
BOC-O-benzyl-L-serine
Boc-DPal
N-Boc-D-(4-Cl)Phe-OH
Boc-D-2Nal-OH
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
Stage #1: polyethylene glycol polyamide resin; Boc-(R)-Ala With benzotriazol-1-ol; diisopropyl-carbodiimide for 4h; MBHA resin; Stage #2: With trifluoroacetic acid In dichloromethane MBHA resin; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; N-tert-butoxycarbonyl-L-leucine; BOC-O-benzyl-L-serine; Boc-DPal; N-Boc-D-(4-Cl)Phe-OH; Boc-D-2Nal-OH; Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine; (S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; Nα-(tert-butyloxycarbonyl)-p-ureido-D-phenylalanine; acetylating agent Further stages; |
1-(tert-butoxycarbonyl)-L-proline
Boc-(R)-Ala
BOC-O-benzyl-L-serine
Boc-Nle-OH
Boc-DPal
N-Boc-D-(4-Cl)Phe-OH
Boc-D-2Nal-OH
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
Stage #1: polyethylene glycol polyamide resin; Boc-(R)-Ala With benzotriazol-1-ol; diisopropyl-carbodiimide for 4h; MBHA resin; Stage #2: With trifluoroacetic acid In dichloromethane MBHA resin; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; BOC-O-benzyl-L-serine; Boc-Nle-OH; Boc-DPal; N-Boc-D-(4-Cl)Phe-OH; Boc-D-2Nal-OH; Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine; (S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; Nα-(tert-butyloxycarbonyl)-p-ureido-D-phenylalanine; acetylating agent Further stages; |
1-(tert-butoxycarbonyl)-L-proline
N-(tert-butyloxycarbonyl)-L-isoleucine
Boc-(R)-Ala
BOC-O-benzyl-L-serine
Boc-DPal
N-Boc-D-(4-Cl)Phe-OH
Boc-D-2Nal-OH
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
Stage #1: polyethylene glycol polyamide resin; Boc-(R)-Ala With benzotriazol-1-ol; diisopropyl-carbodiimide for 4h; MBHA resin; Stage #2: With trifluoroacetic acid In dichloromethane MBHA resin; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; N-(tert-butyloxycarbonyl)-L-isoleucine; BOC-O-benzyl-L-serine; Boc-DPal; N-Boc-D-(4-Cl)Phe-OH; Boc-D-2Nal-OH; Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine; (S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; Nα-(tert-butyloxycarbonyl)-p-ureido-D-phenylalanine; acetylating agent Further stages; |
1-(tert-butoxycarbonyl)-L-proline
t-Boc-L-valine
Boc-(R)-Ala
BOC-O-benzyl-L-serine
Boc-DPal
N-Boc-D-(4-Cl)Phe-OH
Boc-D-2Nal-OH
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
Stage #1: polyethylene glycol polyamide resin; Boc-(R)-Ala With benzotriazol-1-ol; diisopropyl-carbodiimide for 4h; MBHA resin; Stage #2: With trifluoroacetic acid In dichloromethane MBHA resin; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; t-Boc-L-valine; BOC-O-benzyl-L-serine; Boc-DPal; N-Boc-D-(4-Cl)Phe-OH; Boc-D-2Nal-OH; Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine; (S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; Nα-(tert-butyloxycarbonyl)-p-ureido-D-phenylalanine; acetylating agent Further stages; |
1-(tert-butoxycarbonyl)-L-proline
Boc-(R)-Ala
BOC-O-benzyl-L-serine
Boc-DPal
N-Boc-D-(4-Cl)Phe-OH
Boc-D-2Nal-OH
1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
Stage #1: polyethylene glycol polyamide resin; Boc-(R)-Ala With benzotriazol-1-ol; diisopropyl-carbodiimide for 4h; MBHA resin; Stage #2: With trifluoroacetic acid In dichloromethane MBHA resin; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; BOC-O-benzyl-L-serine; Boc-DPal; N-Boc-D-(4-Cl)Phe-OH; Boc-D-2Nal-OH; 1-<(tert-butyloxy)carbonylamino>cyclopropane-1-carboxylic acid; Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine; (S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; Nα-(tert-butyloxycarbonyl)-p-ureido-D-phenylalanine; acetylating agent Further stages; |
1-(tert-butoxycarbonyl)-L-proline
N-tert-butoxycarbonyl-L-methionine
Boc-(R)-Ala
BOC-O-benzyl-L-serine
Boc-DPal
N-Boc-D-(4-Cl)Phe-OH
Boc-D-2Nal-OH
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
Stage #1: polyethylene glycol polyamide resin; Boc-(R)-Ala With benzotriazol-1-ol; diisopropyl-carbodiimide for 4h; MBHA resin; Stage #2: With trifluoroacetic acid In dichloromethane MBHA resin; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; N-tert-butoxycarbonyl-L-methionine; BOC-O-benzyl-L-serine; Boc-DPal; N-Boc-D-(4-Cl)Phe-OH; Boc-D-2Nal-OH; Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine; (S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; Nα-(tert-butyloxycarbonyl)-p-ureido-D-phenylalanine; acetylating agent Further stages; |
1-(tert-butoxycarbonyl)-L-proline
Boc-(R)-Ala
N-tert-butoxycarbonyl-L-phenylalanine
BOC-O-benzyl-L-serine
Boc-DPal
N-Boc-D-(4-Cl)Phe-OH
Boc-D-2Nal-OH
Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine
(S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid
Conditions | Yield |
---|---|
Stage #1: polyethylene glycol polyamide resin; Boc-(R)-Ala With benzotriazol-1-ol; diisopropyl-carbodiimide for 4h; MBHA resin; Stage #2: With trifluoroacetic acid In dichloromethane MBHA resin; Stage #3: 1-(tert-butoxycarbonyl)-L-proline; N-tert-butoxycarbonyl-L-phenylalanine; BOC-O-benzyl-L-serine; Boc-DPal; N-Boc-D-(4-Cl)Phe-OH; Boc-D-2Nal-OH; Nα-tert-butyloxycarbonyl-Nε-benzyloxycarbonyl-Nε-isopropyl-L-lysine; (S)-3-(4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)phenyl)-2-((tert-butoxycarbonyl)amino)propanoic acid; Nα-(tert-butyloxycarbonyl)-p-ureido-D-phenylalanine; acetylating agent Further stages; |