CAS No.133909-99-6,Trityl losartan Suppliers

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Basic Information

Molecular Structure:
CAS No.:	133909-99-6
Name:	Trityl losartan
Article Data:	16
Cas Database

Formula:	C₄₁H₃₇ClN₆O
Molecular Weight:	665.237
Synonyms:	2-Butyl-4-chloro-1-[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]-1H-imidazole-5-methanol;(2-Butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol;
EINECS:	412-420-5
Density:	1.22 g/cm³
Boiling Point:	856.6 °C at 760 mmHg
Flash Point:	471.9 °C
Risk Codes:	53
Safety:	61
PSA:	81.65000
LogP:	8.58040

Synthetic route

: 83857-96-9
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
Stage #1: 2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde; N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole With potassium carbonate In N,N-dimethyl-formamide at 20 - 22℃; for 3h; Stage #2: With sodium tetrahydroborate In water; N,N-dimethyl-formamide at 48 - 52℃; for 3.08333h;	99.2%
With potassium carbonate In N,N-dimethyl acetamide
With potassium carbonate In N,N-dimethyl acetamide

: 76-83-5
trityl chloride

: 124750-99-8
cozaar

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
With triethylamine In N,N-dimethyl-formamide at 20℃; for 18h;	91%

: 79047-41-9
2-n-butyl-4-chloro-5-hydroxymethylimidazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 10h;	80%

: 109-69-3
n-Butyl chloride

: 133910-00-6
2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-carboxaldehyde

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
With sodium borohydrid In water; ethyl acetate	72%
With sodium borohydrid In water; ethyl acetate	72%

: 133910-00-6
2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-carboxaldehyde

: 99281-96-6
3-<3,4-bis(benzyloxy)phenyl>-1-aminopropane

A: 1370339-88-0
[3-(3,4-bis-benzyloxy-phenyl)propyl](2-n-butyl-5-chloro-3-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-imidazol-4-ylmethyl)amine

B: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
Stage #1: 2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-carboxaldehyde; 3-<3,4-bis(benzyloxy)phenyl>-1-aminopropane With magnesium sulfate In dichloromethane at 20℃; for 17h; Inert atmosphere; Stage #2: With sodium tetrahydroborate In methanol; dichloromethane at 20℃; for 4h; Inert atmosphere;	A 34% B 40%

...Expand

: 109-69-3
n-Butyl chloride

: 83857-96-9
2-n-butyl-4-chloro-1H-imidazol-5-carboxaldehyde

: 143722-28-5
5-(4'-Methanesulfonyloxymethyl-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
With sodium borohydrid In water; ethyl acetate; acetone	28%
With sodium borohydrid In water; ethyl acetate; acetone	28%

...Expand

: 79047-41-9
2-n-butyl-4-chloro-5-hydroxymethylimidazole

: 133051-88-4
N-(triphenylmethyl)-5-<4'-(bromomethyl)biphenyl-2-yl>tetrazole

A: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

B: {2-Butyl-5-chloro-1-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-imidazol-4-yl}-methanol

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide Product distribution; Ambient temperature; various ratios of reagents;
With potassium carbonate In N,N-dimethyl-formamide Ambient temperature;

...Expand

: 76-83-5
trityl chloride

: 114772-55-3
2-n-Butyl-4-chloro-1-[(2'-cyanobiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
Yield given. Multistep reaction;

: 133910-00-6
2-n-Butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-carboxaldehyde

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
With sodium tetrahydroborate In dichloromethane at 25℃; for 24h; Yield given;

: 87268-78-8
2-trityl-5-phenyl-2H-tetrazole

: 151012-31-6
2-n-Butyl-4-chloro-1-(4-bromobenzyl)-1H-imidazole-5-methanol

: 133909-99-6
2-n-butyl-4-chloro-1-[(2'-(2-triphenylmethyl-2H-tetrazol-5-yl)-1,1'-biphenyl-4-yl)methyl]-1H-imidazole-5-methanol

Conditions

Conditions	Yield
Yield given. Multistep reaction;

Total:77 Page 1 of 3 1 2 3 Next>>

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Specification

The Trityl Losartan with CAS registry number of 133909-99-6 is also known as 2-Butyl-4-chloro-1-[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]-1H-imidazole-5-methanol. The systematic name is (2-Butyl-4-chloro-1-{[2'-(2-trityl-2H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol. Its EINECS registry number is 412-420-5. In addition, the formula is C₄₁H₃₇ClN₆O and the molecular weight is 665.23.

Physical properties about Trityl Losartan are: (1)ACD/LogP: 8.45; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): 8.42; (4)ACD/LogD (pH 7.4): 8.45; (5)ACD/BCF (pH 5.5): 1000000; (6)ACD/BCF (pH 7.4): 1000000; (7)ACD/KOC (pH 5.5): 872888.94; (8)ACD/KOC (pH 7.4): 937635.38; (9)#H bond acceptors: 7; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 13; (12)Index of Refraction: 1.656; (13)Molar Refractivity: 199.59 cm³; (14)Molar Volume: 542.9 cm³; (15)Surface Tension: 49.8 dyne/cm; (16)Density: 1.22 g/cm³; (17)Flash Point: 471.9 °C; (18)Enthalpy of Vaporization: 130.44 kJ/mol; (19)Boiling Point: 856.6 °C at 760 mmHg; (20)Vapour Pressure: 2.96E-31 mmHg at 25 °C.

When you are using this chemical, please be cautious about it. As a chemical, it may cause long-term adverse effects in the aquatic environment. During using it, avoid release to the environment refer to special instructions/safety data sheet.

You can still convert the following datas into molecular structure:
1. SMILES: Clc1nc(n(c1CO)Cc2ccc(cc2)c7ccccc7c3nn(nn3)C(c4ccccc4)(c5ccccc5)c6ccccc6)CCCC
2. InChI: InChI=1/C41H37ClN6O/c1-2-3-23-38-43-39(42)37(29-49)47(38)28-30-24-26-31(27-25-30)35-21-13-14-22-36(35)40-44-46-48(45-40)41(32-15-7-4-8-16-32,33-17-9-5-10-18-33)34-19-11-6-12-20-34/h4-22,24-27,49H,2-3,23,28-29H2,1H3
3. InChIKey: QQPGGBNMTNDKEY-UHFFFAOYAZ