CAS No.13710-19-5,N-(3-Chloro-ortho-tolyl) anthranilic acid Suppliers

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Basic Information

Molecular Structure:
CAS No.:	13710-19-5
Name:	N-(3-Chloro-ortho-tolyl) anthranilic acid
Article Data:	16

Formula:	C₁₄H₁₂ClNO₂
Molecular Weight:	261.708
Synonyms:	N-(3-Chloro-o-tolyl)anthranilicacid;N-(2-Methyl-3-chlorophenyl)anthranilic acid;GEA 6414;Migea;Tolfedine;Anthranilicacid, N-(3-chloro-o-tolyl)- (7CI,8CI);Clotam;Tolfine;
EINECS:	237-264-3
Density:	1.333 g/cm³
Melting Point:	210-214 °C
Boiling Point:	405.4 °C at 760 mmHg
Flash Point:	199 °C
Solubility:	Soluble in water (slightly), acetone (~10 mg/ml), DMSO (52 mg/ml at 25°C), methanol (~10 mg/ml) and ethanol (50 mg/ml).
Hazard Symbols:	Xn
Risk Codes:	22
Transport Information:	UN 2811 6.1/PG 3
PSA:	49.33000
LogP:	4.16320

Synthetic route

: 87-60-5
3-chloro-2-methylbenzenamine

: 118-91-2
ortho-chlorobenzoic acid

: 13710-19-5
tolfenamic Acid

Conditions

Conditions	Yield
Stage #1: ortho-chlorobenzoic acid With sodium hydroxide for 1h; Reflux; Stage #2: 3-chloro-2-methylbenzenamine With aluminum oxide; sodium hydroxide for 3h; Reflux;	88.6%
With copper(l) iodide; potassium carbonate; potassium iodide In water at 55 - 100℃; for 12h; Reagent/catalyst; Inert atmosphere;	60%

: 87-60-5
3-chloro-2-methylbenzenamine

: 88-65-3
2-bromobenzoic-acid

: 13710-19-5
tolfenamic Acid

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; potassium iodide In water at 55 - 100℃; for 6h; Reagent/catalyst; Inert atmosphere;	83.1%

: 88-67-5
2-Iodobenzoic acid

: 87-60-5
3-chloro-2-methylbenzenamine

: 13710-19-5
tolfenamic Acid

Conditions

Conditions	Yield
With copper(l) iodide; potassium carbonate; potassium iodide In water at 55 - 100℃; for 4h; Reagent/catalyst; Inert atmosphere;	82%
With copper; potassium carbonate In N,N-dimethyl-formamide at 100℃; for 12h; Schlenk technique; Inert atmosphere;

: 16497-87-3
potassium 2-bromobenzoate

: 87-60-5
3-chloro-2-methylbenzenamine

: 13710-19-5
tolfenamic Acid

Conditions

Conditions	Yield
With N-ethylmorpholine;; copper diacetate In N,N-dimethyl-formamide at 145℃; for 4h; Ullmann-Goldberg condensation;	40%
With N-ethylmorpholine;; copper diacetate In N,N-dimethyl-formamide at 145℃; for 3h;

: 12775-96-1, 15158-11-9, 15721-63-8, 16941-75-6, 17493-86-6, 19498-52-3, 20499-83-6, 20499-84-7, 20499-85-8, 20499-86-9, 20573-10-8, 20573-11-9, 21595-51-7, 21595-52-8, 22206-52-6, 26445-28-3, 28959-95-7, 37362-93-9, 39417-05-5, 54603-16-6, 54603-23-5, 54603-32-6, 54603-40-6, 54603-48-4, 54603-81-5, 54603-89-3, 56316-56-4, 95985-91-4, 122297-32-9, 7440-50-8
copper

: 87-60-5
3-chloro-2-methylbenzenamine

: 88-65-3
2-bromobenzoic-acid

A: 13710-22-0
N-(3-chlorotolyl)-anthranilic acid

B: 13710-19-5
tolfenamic Acid

Conditions

Conditions	Yield
With potassium hydroxide; sodium carbonate In pentan-1-ol; water

...Expand

: 42048-11-3
2-chloro-6-iodotoluene

: 118-92-3
anthranilic acid

: 13710-19-5
tolfenamic Acid

Conditions

Conditions	Yield
With potassium acetate; copper diacetate; copper at 140℃; Inert atmosphere;

: C14H11ClN2

: 13710-19-5
tolfenamic Acid

Conditions

Conditions	Yield
With water; potassium hydroxide In ethanol at 95℃; for 16h; Inert atmosphere;	192 mg

: (3-chloro-2-methylphenyl)boronic acid

: 612-24-8
o-nitrobenzonitrile

: 13710-19-5
tolfenamic Acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: phenylsilane; 1,2,2,3,4,4-hexamethylphosphetane 1-oxide / m-xylene / 5 h / 120 °C / Inert atmosphere 2: potassium hydroxide; water / ethanol / 16 h / 95 °C / Inert atmosphere View Scheme

: 768-94-5
1-Adamantanamine

: 13710-19-5
tolfenamic Acid

: C10H17N*C14H12ClNO2

Conditions

Conditions	Yield
In methanol at 20℃;	100%

: 64-04-0
phenethylamine

: 13710-19-5
tolfenamic Acid

: C14H12ClNO2*C8H11N

Conditions

Conditions	Yield
In methanol at 20℃;	100%

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Chemistry

Product Name: N-(3-Chloro-ortho-tolyl) anthranilic acid
The MF of N-(3-Chloro-ortho-tolyl) anthranilic acid(13710-19-5) is C₁₄H₁₂ClNO₂.

The MW of N-(3-Chloro-ortho-tolyl) anthranilic acid(13710-19-5) is 261.7.
Synonyms: CLOTAM;LABOTEST-BB LT00772313;2-(3-CHLORO-O-TOLUIDINO)BENZOIC ACID;2 (3-CHLORO-2-METHYLANILINO)BENZOIC ACID;gea6414;2-[(3-CHLORO-2-METHYLPHENYL)AMINO]BENZOIC ACID;TOLFENAMIC ACID;2-((3-chloro-2-methylphenyl)amino)-benzoicaci
Product Categories: Active Pharmaceutical Ingredients
Mol File: 13710-19-5.mol
EINECS: 237-264-3
Surface Tension: 55.7 dyne/cm
Density: 1.333 g/ml
Flash Point: 199 °C
Enthalpy of Vaporization: 69.28 kJ/mol
Boiling Point: 405.4 °C at 760 mmHg
Vapour Pressure: 2.66E-07 mmHg at 25°C
mp: 210-214°C
Merck: 9513
CAS DataBase Reference: 13710-19-5(CAS DataBase Reference)

Uses

The N-(3-Chloro-ortho-tolyl) anthranilic acid(13710-19-5) is used as the synthesis of non-steroidal anti-inflammatory analgesic.

Toxicity Data With Reference

1.	orl-rat LD50:225 mg/kg	TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 28 (1981),99.
2.	ipr-rat LD50:238 mg/kg	TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. 29 (1983),851.
3.	scu-rat LD50:246 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 14 (1983),838.
4.	orl-mus LD50:280 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 14 (1983),838.
5.	ipr-mus LD50:185 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 14 (1983),838.
6.	scu-mus LD50:267 mg/kg	IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. 14 (1983),838.

Safety Profile

Poison by ingestion, subcutaneous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cl⁻ and NO_x.
Safety information of N-(3-Chloro-ortho-tolyl) anthranilic acid(13710-19-5):
Hazard Codes:

Xn
Risk Statements: 22
R22: Harmful if swallowed ;
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
RTECS: CB2687500

Specification

The N-(3-Chloro-ortho-tolyl) anthranilic acid(13710-19-5) is stable under normal temperatures and pressures.Decomposition are carbon monoxide, carbon dioxide, nitrogen oxides, hydrogen chloride gas.