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139481-59-7

Basic Information
CAS No.: 139481-59-7
Name: Candesartan
Molecular Structure:
Molecular Structure of 139481-59-7 (Candesartan)
Formula: C24H20N6O3
Molecular Weight: 440.45
Synonyms: Blopress (TN);Candesartan [USAN:INN];Blopress;CV 11974;2-Ethoxy-1-(p-(o-1H-tetrazol-5-ylphenyl)benzyl)-7-benzimidazolecarboxylic acid;Candesartan (USAN);1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-((2-(1H-tetrazol-5-yl)(1,1-biphenyl)-4-yl)methyl)-;Cyclohexyl-1-Chloro Ethyl Carbamate;
EINECS: 604-138-8
Density: 1.41 g/cm3
Melting Point: 183-185 °C
Boiling Point: 754.8 °C at 760 mmHg
Flash Point: 410.3 °C
Solubility: Soluble in ethyl acetate, methanol, water (<1 mg/ml at 25°C), DMSO (88 mg/ml at 25°C), and ethanol (1 mg/ml at 25°C).
Appearance: crystalline solid
Hazard Symbols: HarmfulXn
Risk Codes: 20/21/22-36/37/38
Safety: 26-36
Transport Information:
PSA: 118.81000
LogP: 4.02860
Synthetic route
139481-69-9

methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
Stage #1: methyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate With sodium hydroxide; water In methanol at 78 - 80℃; for 1h;
Stage #2: With acetic acid In ethyl acetate at 10 - 15℃; pH=4 - 5;
95%
With methanol; sodium hydroxide; water at 10 - 70℃;90%
With sodium hydroxide In methanol at 80 - 90℃; for 1h;85%
856414-35-2

ethyl 2-ethoxy-1-{[2'-[1-(triphenylmethyl)-1H-tetrazol-5-yl]-1,1'-biphenyl-4-yl]methyl}-benzimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
With lithium hydroxide In ethanol at 80℃; for 3h;85%
139481-58-6

ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
Stage #1: ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate With sodium hydroxide; ethanol; water for 24h; Heating / reflux;
Stage #2: With hydrogenchloride In ethanol; water pH=4 - 4.5;
80%
Stage #1: ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate With sodium hydroxide; water In o-xylene at 25 - 65℃; for 3h;
Stage #2: With acetic acid In methanol pH=4.5 - 5.5;
With water; sodium hydroxide at 40 - 80℃; Reagent/catalyst;

candesartan cilexetil

A

methanol-methyl carbonate

B

139481-59-7

candesartan

C

108-93-0

cyclohexanol

Conditions
ConditionsYield
With sodium hydroxide In methanol; dichloromethane at 30℃; for 8h;A n/a
B 78.01%
C n/a
914771-42-9

methanol ethyl acetate

139481-58-6

ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
With sodium hydroxide In ethanol67%
21606-04-2

methyl 2-carboxy-3-nitrobenzoate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 9 steps
1: SOCl2, DMF / toluene / 0.5 h / Heating
2: NaN3 / acetone; H2O / 1 h
3: 1.5 h / Heating
4: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
5: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
6: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
7: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
8: 100 percent / trimethyltin azide / toluene / 29 h / Heating
9: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 7 steps
1.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2.5 h / 75 °C
2.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
2.2: 1 h / 80 - 85 °C
3.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
3.2: 3 h / Reflux
4.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
4.2: 4.5 h / -10 - 0 °C
4.3: 0.5 h / Reflux
5.1: acetic acid / toluene / 6 h / Reflux
6.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
6.2: 0 - 20 °C
7.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
7.2: 3 h / 0 °C / pH 4
View Scheme
73833-13-3

acid chloride of 1-methylhydrogen-3-nitrophthalate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 8 steps
1: NaN3 / acetone; H2O / 1 h
2: 1.5 h / Heating
3: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
4: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
5: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
6: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
7: 100 percent / trimethyltin azide / toluene / 29 h / Heating
8: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 6 steps
1.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
1.2: 1 h / 80 - 85 °C
2.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
2.2: 3 h / Reflux
3.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
3.2: 4.5 h / -10 - 0 °C
3.3: 0.5 h / Reflux
4.1: acetic acid / toluene / 6 h / Reflux
5.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
5.2: 0 - 20 °C
6.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
6.2: 3 h / 0 °C / pH 4
View Scheme
603-11-2

3-nitrophthalic acid

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 10 steps
1: concd. H2SO4 / methanol
2: SOCl2, DMF / toluene / 0.5 h / Heating
3: NaN3 / acetone; H2O / 1 h
4: 1.5 h / Heating
5: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
6: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
7: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
8: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
9: 100 percent / trimethyltin azide / toluene / 29 h / Heating
10: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 8 steps
1.1: sulfuric acid / 24.75 h / 20 - 65 °C
2.1: N,N-dimethyl-formamide; thionyl chloride / toluene / 2.5 h / 75 °C
3.1: sodium azide; tetrabutylammomium bromide / toluene / 4 h / -10 - -5 °C
3.2: 1 h / 80 - 85 °C
4.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
4.2: 3 h / Reflux
5.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
5.2: 4.5 h / -10 - 0 °C
5.3: 0.5 h / Reflux
6.1: acetic acid / toluene / 6 h / Reflux
7.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
7.2: 0 - 20 °C
8.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
8.2: 3 h / 0 °C / pH 4
View Scheme
57113-90-3

methyl 2-(N-tert-butoxycarbonylamino)-3-nitrobenzoate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
2: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
3: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
4: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
5: 100 percent / trimethyltin azide / toluene / 29 h / Heating
6: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 5 steps
1.1: potassium carbonate; tetrabutylammomium bromide / toluene / 12 h / 80 - 85 °C
1.2: 3 h / Reflux
2.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
2.2: 4.5 h / -10 - 0 °C
2.3: 0.5 h / Reflux
3.1: acetic acid / toluene / 6 h / Reflux
4.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
4.2: 0 - 20 °C
5.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
5.2: 3 h / 0 °C / pH 4
View Scheme
856414-36-3

2-Azidocarbonyl-3-nitro-benzoic acid methyl ester

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1: 1.5 h / Heating
2: 85 percent / K2CO3 / acetonitrile / 4 h / Heating
3: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
4: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
5: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
6: 100 percent / trimethyltin azide / toluene / 29 h / Heating
7: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
136304-78-4

methyl 3-amino-2-[[(2'-cyanobiphenyl-4-yl)methyl]amino]benzoate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
2: 100 percent / trimethyltin azide / toluene / 29 h / Heating
3: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 3 steps
1.1: acetic acid / toluene / 6 h / Reflux
2.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
2.2: 0 - 20 °C
3.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
3.2: 3 h / 0 °C / pH 4
View Scheme
139481-28-0

methyl 2-<<2'-cyanobiphenyl-4-yl)methyl>amino>-3-nitrobenzoate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
2: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
3: 100 percent / trimethyltin azide / toluene / 29 h / Heating
4: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 4 steps
1.1: tin(ll) chloride / ethyl acetate / 1.5 h / Reflux
1.2: 4.5 h / -10 - 0 °C
1.3: 0.5 h / Reflux
2.1: acetic acid / toluene / 6 h / Reflux
3.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
3.2: 0 - 20 °C
4.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
4.2: 3 h / 0 °C / pH 4
View Scheme
139481-44-0

methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-benzimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 100 percent / trimethyltin azide / toluene / 29 h / Heating
2: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme
Multi-step reaction with 2 steps
1: azido tributyltin (IV) / N,N-dimethyl-formamide / 20 h / 140 - 150 °C
2: sodium hydroxide; water / 20 h / 70 - 80 °C
View Scheme
139481-38-2

methyl 2-amino>-3-nitrobenzoate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 77 percent / 30percent ethanolic HCl / ethyl acetate / 1 h / Ambient temperature
2: 1.) FeCl3*6H2O, activated carbon, 2.) hydrazine monohydrate / 1.) MeOH, THF, reflux, 30 min, 2.) MeOH, THF, reflux, 14 h
3: 91 percent / acetic acid / 0.67 h / 80 - 90 °C
4: 100 percent / trimethyltin azide / toluene / 29 h / Heating
5: 85 percent / 1 N aq. NaOH / methanol / 1 h / 80 - 90 °C
View Scheme

methyl 1-[(2-cyanobiphenyl-4-yl)methyl]-2-ethoxybenzimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium azide; tributyltin chloride / toluene / 100 h / Reflux
1.2: 0 - 20 °C
2.1: sodium hydroxide; water / ethanol / 3.5 h / Reflux
2.2: 3 h / 0 °C / pH 4
View Scheme
145040-37-5

candesartan cilexetil

139481-59-7

candesartan

Conditions
ConditionsYield
With Bis(p-nitrophenyl) phosphate In dimethyl sulfoxide; acetonitrile at 37℃; for 0.0333333h; pH=7.5; Reagent/catalyst; Enzymatic reaction;

methyl 2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
With methanol; sodium hydroxide at 50℃; for 3h;44.5 g
150058-27-8

2-ethoxy-1H-benzimidazole-7-carboxylic acid methyl ester

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium tert-butylate / N,N-dimethyl acetamide / 60 °C / Inert atmosphere
2: sodium hydroxide; methanol / 3 h / 50 °C
View Scheme
139481-41-7

ethyl 1-[(2'-cyano-[1,1']-biphenyl-4-yl)methyl]-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: azido tributyltin (IV) / 5,5-dimethyl-1,3-cyclohexadiene / 20 h / 140 - 150 °C
2: sodium hydroxide; water / 40 - 80 °C
View Scheme
854538-88-8

ethyl 1-(4-bromobenzyl)-2-ethoxy-benzimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
2.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
2.2: pH 4 - 4.5
View Scheme
916891-90-2

ethyl 3-amino-2-(4-bromobenzylamine)-benzoate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: acetic acid / 1 h / 80 °C
2.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
3.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
3.2: pH 4 - 4.5
View Scheme
854538-89-9

ethyl 2-(4-bromobenzylamine)-3-nitrobenzoate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux
1.2: 0 °C
2.1: sodium hydroxide; water
3.1: acetic acid / 1 h / 80 °C
4.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
5.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
5.2: pH 4 - 4.5
View Scheme

ethyl 3-amino-2-(4-bromobenzylamine)-benzoate hydrochloride

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: sodium hydroxide; water
2.1: acetic acid / 1 h / 80 °C
3.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
4.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
4.2: pH 4 - 4.5
View Scheme
916891-91-3

ethyl 2-ethoxy-1-[[2'-[(1-methyl-1-phenyl-ethyl)-2H-tetrazol-5-yl]-[1,1']biphenyl-4-yl]methyl]-1H-benzoimidazole-7-carboxylate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: sodium formate / palladium 10% on activated carbon / ethanol / 72 h / Heating / reflux
2.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
2.2: pH 4 - 4.5
View Scheme
3979-45-1

ethyl 2-chloro-3-nitrobenzoate

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 6 steps
1.1: triethylamine / toluene / 12 h / Heating / reflux
2.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux
2.2: 0 °C
3.1: sodium hydroxide; water
4.1: acetic acid / 1 h / 80 °C
5.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
6.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
6.2: pH 4 - 4.5
View Scheme
3970-35-2

2-chloro-3-nitrobezoic acid

139481-59-7

candesartan

Conditions
ConditionsYield
Multi-step reaction with 7 steps
1.1: sulfuric acid / 24 h / 15 - 30 °C / Heating / reflux
2.1: triethylamine / toluene / 12 h / Heating / reflux
3.1: tin(ll) chloride / ethanol / 2 h / Heating / reflux
3.2: 0 °C
4.1: sodium hydroxide; water
5.1: acetic acid / 1 h / 80 °C
6.1: potassium carbonate / palladium diacetate; triphenylphosphine / water; toluene / 16 h / 60 - 70 °C
7.1: sodium hydroxide; ethanol; water / 24 h / Heating / reflux
7.2: pH 4 - 4.5
View Scheme
139481-59-7

candesartan

924654-25-1

(1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazol-7-yl)methanol

Conditions
ConditionsYield
Stage #1: candesartan With lithium aluminium tetrahydride In tetrahydrofuran at -78 - 50℃; for 6.5h;
Stage #2: With hydrogenchloride In tetrahydrofuran; water
96.5%
With lithium aluminium tetrahydride In tetrahydrofuran at -78℃;90%
Stage #1: candesartan With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;
Stage #2: With water In tetrahydrofuran at 0℃; for 0.5h;
77%
With lithium aluminium tetrahydride In tetrahydrofuran at 20℃;77%
76-83-5

trityl chloride

139481-59-7

candesartan

139481-72-4

2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane at 15 - 23℃; for 3.5h; Temperature; Flow reactor; Large scale;94%
With triethylamine In acetone at 55 - 60℃; for 4 - 8h; Product distribution / selectivity;90%
With triethylamine In acetone at 55 - 60℃; Product distribution / selectivity;90%
139481-59-7

candesartan

C24H20N6O3*H3N

Conditions
ConditionsYield
With ammonium hydroxide In water for 2h;89%
107-15-3

ethylenediamine

139481-59-7

candesartan

C24H20N6O3*C2H8N2

Conditions
ConditionsYield
In water for 2h;85%
109-76-2

Trimethylenediamine

139481-59-7

candesartan

C24H20N6O3*C3H10N2

Conditions
ConditionsYield
In water for 2h;80%
76-83-5

trityl chloride

139481-59-7

candesartan

894806-43-0

2-ethoxy-1-<<2'-biphenyl-4-yl>methyl>-1H-benzimidazole-7-carboxylic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane for 1h; Ambient temperature;76%
5970-45-6

zinc(II) acetate dihydrate

68-12-2, 33513-42-7

N,N-dimethyl-formamide

139481-59-7

candesartan

C24H18N6O3(2-)*2C3H7NO*Zn(2+)

Conditions
ConditionsYield
In methanol68%
ethyl acetate-benzene

ethyl acetate-benzene

76-83-5

trityl chloride

139481-59-7

candesartan

139481-72-4

2-Ethoxy-1-[[2'-(N-triphenylmethyltetrazol-5-yl)-biphenyl-4-yl]methyl]benzimidazole-7-carboxylic acid

Conditions
ConditionsYield
With triethylamine In dichloromethane66%
110-86-1

pyridine

139481-59-7

candesartan

cadmium(II) iodide

C24H18N6O3(2-)*Cd(2+)*C5H5N*H2O

Conditions
ConditionsYield
In methanol at 150℃; for 72h; Autoclave;56%
553-26-4

4,4'-bipyridine

zinc(II) sulfate heptahydrate

139481-59-7

candesartan

2C24H18N6O3(2-)*2Zn(2+)*C10H8N2

Conditions
ConditionsYield
In methanol; water at 135℃; for 72h; Autoclave;45%
1160386-36-6

1-chloromethyl-3-methylbutylamine hydrochloride

139481-59-7

candesartan

1160386-25-3

2-Ethoxy-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid (1-chloromethyl-3-methylbutyl)amide

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine In DCM at 20℃;15%
139481-59-7

candesartan

63700-19-6

uridine-5'-diphospho-α-D-glucuronic acid trisodium salt

candesartan-O-glucuronide

Conditions
ConditionsYield
With saccharic acid-1,4-lactone; recombinant human UDP-glucuronyltransferase 1A8 at 37℃; for 48h;7.4%
139481-59-7

candesartan

63700-19-6

uridine-5'-diphospho-α-D-glucuronic acid trisodium salt

candesartan-N2-glucuronide

Conditions
ConditionsYield
With saccharic acid-1,4-lactone; recombinant human UDP-glucuronyltransferase 1A3 at 37℃; for 48h;4%
139481-59-7

candesartan

2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid acetoxymethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature
2: potassium iodide, potassium carbonate / dimethylformamide / 2 h / 60 °C
3: 1N aq. HCl / methanol / 1.5 h / Ambient temperature
View Scheme
139481-59-7

candesartan

2-Ethoxy-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazole-4-carboxylic acid 1-acetoxy-ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 76 percent / triethylamine / CH2Cl2 / 1 h / Ambient temperature
2: potassium iodide, potassium carbonate / dimethylformamide / 2 h / 60 °C
3: 1N aq. HCl / methanol / 1.5 h / Ambient temperature
View Scheme
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    Dayang Chem (Hangzhou) Co.,Ltd. dedicated to the development, production and marketing of chemicals which is specialized in Organic compounds; Active Pharmaceutical Ingredi

  •  Dayang Chem (Hangzhou) Co.,Ltd.

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    Business Type:Lab/Research institutions

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    Business Type:Lab/Research institutions

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     China (Mainland)  |  Contact Details

    Business Type:Other

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-21-52196435

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     China (Mainland)  |  Contact Details

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    Business Type:Trading Company

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    SHANGHAI MINSTAR CHEMICAL CO., LTD. is a leading, experienced, professional supplier of API & intermediates, plant extract, food additive, fine chemicals and industry chemicals, et

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:0086-21-18019205509

    Address:BUILDING 8, NO.1098, CHUANSHA ROAD, SHANGHAI, CHINA

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    Business Type:Trading Company

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    Business Type:Trading Company

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    Business Type:Lab/Research institutions

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    span lang="EN-US" style="font-size: 9.0pt;font-family:"Arial",sans-serif;color:#4D4D4D">As a leading manufacturer and supplier of chemicals in china, weckchem not only supply popular chemicals, but also weckchem’s r&d center off

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    Business Type:Other

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    Address:Xiaoshan district

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

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    Address:No. 8 Building, 18 nong, Xi Yingnan Road, Pudong, Shanghai,China

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-27-65522452

    Address:No. 388 Gaoxin Road(No. 2), East Lake Hi-tech Development Zone, Wuhan, Hubei Province, PRC

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    AFINE CHEMICALS LIMITED is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. Since 2005, we have been rapidly growing to

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-85134551

    Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

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    Address:shandong qingdao

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  •  Zibo Hangyu Import&Export Co., Ltd

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-15988566987

    Address:Room1701, Tianxing Building,Licheng district, jinan, Shandong, China

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    ZHEJIANG BIOLOGY AND TECHNOLOGY CO., LTD. is a modern professional high-tech enterprise, which is specializing in generic APIs and pharmaceutical intermediates. especially in pepti

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    China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:0570-4045877

    Address:46# zhongshan road, quzhou zhejiang

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-021-58380978

    Address:Building 87,Lane 669, Dong Jing Road Shanghai,P.R.China

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  • Candesartan

  • Casno:

    139481-59-7

    Candesartan

    Min.Order: 1 Gram

    FOB Price:  USD $ 1.0-1.0/Gram

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  • Candesartan

  • Casno:

    139481-59-7

    Candesartan

    Min.Order: 0

    FOB Price:  USD $ 0.0-0.0/

    We have strong R&D center which can support and provide custom synthesis accordingly such as fine chemicals,biotechnique , pharmaceuticals etc.We can provide free sample for our clients to test anf verify the quality of our goods.LongyuChem holds str

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    Tel:86-15821988213

    Address:Dalian Rd 950th

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Specification

The Candesartan, with the CAS registry number 139481-59-7, is also known as 2-Ethoxy-3-[[4-[2-(1H-tetrazol-5-yl)phenyl]phenyl]methyl]-3H-benzoimidazole-4-carboxylic acid. It belongs to the product categories of Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Candesartan Cilexatil;Aromatics;Heterocycles.This chemical's molecular formula is C24H20N6O3 and molecular weight is 440.45. What's more,Its systematic name is 1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-.

Physical properties about Candesartan are: (1)ACD/LogP:  4.652; (2)# of Rule of 5 Violations:  0; (3)ACD/LogD (pH 5.5):  1.41; (4)ACD/LogD (pH 7.4):  0.54; (5)ACD/BCF (pH 5.5):  1.16; (6)ACD/BCF (pH 7.4):  1.00; (7)ACD/KOC (pH 5.5):  4.64; (8)ACD/KOC (pH 7.4):  1.00; (9)#H bond acceptors:  9; (10)#H bond donors:  2; (11)#Freely Rotating Bonds:  7; (12)Index of Refraction:  1.719; (13)Molar Refractivity:  122.545 cm3 ; (14)Molar Volume:  310.519 cm3; (15)Surface Tension:  59.6440010070801 dyne/cm; (16)Density:  1.418 g/cm3; (17)Flash Point:  410.262 °C; (18)Enthalpy of Vaporization:  115.396 kJ/mol; (19)Boiling Point:  754.756 °C at 760 mmHg; (20)Vapour Pressure:  0 mmHg at 25°C.

Uses of Candesartan: An angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure.

The Candesartan is harmful by inhalation, in contact with skin and if swallowed. It is irritating to eyes, respiratory system and skin .In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. Whenever you will contact it, please wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C(O)c1cccc2nc(OCC)n(c12)Cc5ccc(c3ccccc3c4nnnn4)cc5;
(2)Std. InChI:InChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29);
(3)Std. InChIKey:HTQMVQVXFRQIKW-UHFFFAOYSA-N;