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144034-80-0

Basic Information
CAS No.: 144034-80-0
Name: 1H-Indole-3-ethanamine,N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-
Molecular Structure:
Molecular Structure of 144034-80-0 (1H-Indole-3-ethanamine,N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-)
Formula: C15H19N5
Molecular Weight: 269.34
Synonyms: 3-[2-(Dimethylamino)ethyl]-5-(1H-1,2,4-triazol-1-ylmethyl)indole;MK 462 free base;N,N-Dimethyl-2-[5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine;Risatriptan;Rizatriptan;
EINECS:
Density: 1.21 g/cm3
Melting Point: 178-180 °C
Boiling Point: 504.8 °C at 760 mmHg
Flash Point: 259.1 °C
Solubility: water: 42 mg/mL
Appearance:
Hazard Symbols:
Risk Codes:
Safety:
Transport Information:
PSA: 49.74000
LogP: 1.91180
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    Name Rizatriptan Synonyms N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine; N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethanamine

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Chemistry

Rizatriptan (144034-80-0) is a 5-HT1 agonist triptan drug developed by Merck & Co. for the treatment of migraine headaches. It is available in strengths of 5 and 10 mg as tablets and orally disintegrating tablets (Maxalt-MLT).

Maxalt obtained approval by the United States Food and Drug Administration (FDA) on June 29, 1998. It is a second-generation triptan.

Rizatriptan(144034-80-0) is available only by prescription in the United States, Canada and New Zealand. Similarly, it is classed as a POM (Prescription Only Medicine) in the United Kingdom, Italy (as Rizaliv) and Israel (as Rizalt).
The density of Rizatriptan(144034-80-0) is 1.21 g/cm3 and it has a melting point of  178-180°C. The boiling point is  504.8 °C at 760 mmHg. The refractive index is about  1.645. Its flash point is  259.1 °C.
The chemical synonyms of Rizatriptan(144034-80-0) are n,n-dimethyl-5-(1h-1,2,4-triazol-1-ylmethyl)-1h-indole-3-ethanamine;n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethanamine;RIZATRIPTAN
The molecular structure of Rizatriptan(144034-80-0):

Uses

Rizatriptan(144034-80-0) is used to treat acute migraine attacks. It does not prevent future migraine attacks.