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CAS No.: | 146-22-5 |
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Name: | Nitrazepam |
Article Data: | 56 |
Molecular Structure: | |
Formula: | C15H11N3O3 |
Molecular Weight: | 281.271 |
Synonyms: | 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepine-2-one;7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one;Benzalin;Calsmin;Dormicum;Dormicum (anticonvulsant);Dormin 5;Eatan;Epibenzalin;Epinelbon;Eunoctin;Hipnax;Hipsal;Imeson;Insomin;Ipersed;LA 1;Megadon;Mogadan;Mogadon;Mogadone;N-Desmethylnimetazepam;NSC 58775;Nelbon;Neozepam;Neuchlonic;Nipam;Nitrados;Nitravet;Nitrazepam;Nitrenpax;Nitrosun;Noctesed;Paxisyn;Pelson;Radedorm;Relact;Remnos;Ro 4-5360;Ro 5-3059;Somitran;Somnased;Somnibel;Somnite;Sonebon;Sonnolin;Surem;Unisomnia;Xiaoxipan;2H-1,4-Benzodiazepin-2-one,1,3-dihydro-7-nitro-5-phenyl-; |
EINECS: | 205-665-2 |
Density: | 1.4 g/cm3 |
Melting Point: | 226-229 ºC |
Boiling Point: | 497 ºC at 760 mmHg |
Flash Point: | 254.4 ºC |
Solubility: | 76.9 mg/L 25 °C in water |
Appearance: | Pink Solid |
Hazard Symbols: | |
Risk Codes: | R22 |
Safety: | Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. An anticonvulsant and hypnotic agent. When heated to decomposition it emits toxic fumes of NOx. See also DIAZEPAM. |
PSA: | 87.28000 |
LogP: | 2.48110 |
Molecular Structure of 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5):
IUPAC Name: 7-Nitro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one
Canonical SMILES: C1C(=O)NC2=C(C=C(C=C2)[N+](=O)[O-])C(=N1)C3=CC=CC=C3
InChI: InChI=1S/C15H11N3O3/c19-14-9-16-15(10-4-2-1-3-5-10)12-8-11(18(20)21)6-7-13(12)17-14/h1-8H,9H2,(H,17,19)
InChIKey: KJONHKAYOJNZEC-UHFFFAOYSA-N
Molecular Weight: 281.26614 [g/mol]
Molecular Formula: C15H11N3O3
XLogP3: 2.2
H-Bond Donor: 1
H-Bond Acceptor: 4
EINECS: 205-665-2
Index of Refraction: 1.689
Molar Refractivity: 76.64 cm3
Molar Volume: 200.6 cm3
Surface Tension: 60.6 dyne/cm
Density: 1.4 g/cm3
Flash Point: 254.4 °C
Enthalpy of Vaporization: 76.49 kJ/mol
Boiling Point: 497 °C at 760 mmHg
Vapour Pressure: 5.15E-10 mmHg at 25 °C
Appearance: Pink Solid
Melting Point: 225 °C
Water Solubility: 76.9 mg/L 25 °C
Classification Code: Anti-Anxiety Agents; Anticonvulsant; Anticonvulsants; Central Nervous System Agents; Central Nervous System Depressants; Drug / Therapeutic Agent; GABA Agents; GABA modulators; Hypnotics and Sedatives; Mutation data; Neurotransmitter Agents; Psychotropic Drugs; Reproductive Effect; Sedative-hypnotic; Tranquilizing Agents
1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5) is used as an anticonvulsant and hypnotic and it is used to controlled substance (depressant).
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
man | TDLo | oral | 11mg/kg (11mg/kg) | BEHAVIORAL: EXCITEMENT VASCULAR: BP ELEVATION NOT CHARACTERIZED IN AUTONOMIC SECTION LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 38, Pg. 2597, 1996. |
mouse | LD50 | intraperitoneal | 275mg/kg (275mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 165, 1972. | |
mouse | LD50 | intravenous | 130mg/kg (130mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#01434, | |
mouse | LD50 | oral | 550mg/kg (550mg/kg) | BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: EXCITEMENT | Vsesoyuznyi Institut Nauchnoi i Tekhnicheskoi Informatsii Vol. #3206-79, |
mouse | LD50 | subcutaneous | > 400mg/kg (400mg/kg) | BEHAVIORAL: EXCITEMENT | Schweizerische Medizinische Wochenschrift. Vol. 95, Pg. 334, 1965. |
rabbit | LD50 | intravenous | 520mg/kg (520mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 165, 1972. | |
rabbit | LD50 | oral | 520mg/kg (520mg/kg) | Schweizerische Medizinische Wochenschrift. Vol. 95, Pg. 334, 1965. | |
rat | LD50 | intraperitoneal | 733mg/kg (733mg/kg) | BEHAVIORAL: ANTICONVULSANT | Journal of Medicinal Chemistry. Vol. 20, Pg. 952, 1977. |
rat | LD50 | oral | 825mg/kg (825mg/kg) | Toxicology and Applied Pharmacology. Vol. 18, Pg. 185, 1971. |
EPA Genetic Toxicology Program.
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Experimental reproductive effects. Mutation data reported. An anticonvulsant and hypnotic agent. When heated to decomposition it emits toxic fumes of NOx.
Safety Information of 1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5):
Hazard Codes: Xn
Risk Statements: 22
R22:Harmful if swallowed.
Safety Statements: 36/37/39
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
RIDADR: 3249
WGK Germany: 3
RTECS: DF2450000
HazardClass: 6.1(b)
PackingGroup: III
1,3-Dihydro-7-nitro-5-phenyl-2H-1,4-benzodiazepin-2-one (CAS NO.146-22-5), its Synonyms are 2,3-Dihydro-7-nitro-5-phenyl-1H-1,4-benzodiazepin-2-on ; 7-Nitro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one ; 7-Nitro-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one ; Apodorm ; Atempol ; Cerson ; Dormicum ; Dormicum (anticonvulsant) ; Dormin-5 ; Dormo-Puren ; Dumolid ; Mogadon ; N-Desmethylnimetazepam ; Nitrazepam .