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CAS No.: | 146-56-5 |
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Name: | FLUPHENAZINE HYDROCHLORIDE |
Molecular Structure: | |
Formula: | C22H28Cl2F3N3OS |
Molecular Weight: | 510.451 |
Synonyms: | 查看更多英文别名查看更多英文别名 | "> fluorophenazine dihydrochloride;Fluphenazine dihydrochloride;Lyorodin;Mirenil;Prolixin;Anatensol;Fluphenazindihydrochlorid;4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride;Fluphenazine hydrochloride;fluphenazine dihydrodchloride;Tensofin;Moditen;Trancin;
EINECS: | 205-674-1 |
Melting Point: | 200-202 °C |
Boiling Point: | 568.3 °C at 760 mmHg |
Flash Point: | 297.5 °C |
Appearance: | Off-white solid |
Hazard Symbols: | Xn |
Risk Codes: | 36/37/38-20/21/22 |
Safety: | 26-36/37/39-36 |
Transport Information: | UN 2811 |
PSA: | 55.25000 |
LogP: | 5.85290 |
Conditions | Yield |
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With hydrogenchloride; sodium nitrite In water for 0.0333333h; chemoselective reaction; | 70% |
fluphenazine dihydrochloride
Conditions | Yield |
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In water at 30℃; pH=1.6; Kinetics; Further Variations:; pH-values; Temperatures; variation of ionic strength, dielectric constant of the medium + halides; |
fluphenazine dihydrochloride
{C12H7NS(CF3)(CH2CH2CH2(C4H8N2)CH2CH2OH)}CuCl2(H2O)2
Conditions | Yield |
---|---|
In acetone soln. of CuCl2 in acetone mixed with soln. of organic compound in acetone, benzene added, mixture concentrated on a heating mantle at 60-70°C; filtered, washed with benzene followed by ether, dried in vac.; elem. anal.; |
Conditions | Yield |
---|---|
In methanol at 59.84℃; for 1h; |
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Chemistry informtion about Fluphenazine Dihydrochloride (CAS NO.146-56-5) is:
IUPAC Name: 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride
Synonyms: 10-(3-(4-(2-Hydroxyethyl)Piperazinyl)Propyl)-2-Trifluoromethylphenothiazine ; 4-(3-(2-(Trifluoromethyl)Phenothiazin-10-Yl)Propyl)-1-Piperazineethanodihy ; 4-(3-(2-(Trifluoromethyl)Phenothiazin-10-Yl)Propyl)-1-Piperazineethanol,Dihy ; 4-[3[2-(Trifluoromethyl)-10h-Phenothiazin-10-Yl]Propyl]-1-Piperazineethano ; A4077 ; Anatensol ; Flufenazin ; Liogen
Product Categories: Active Pharmaceutical Ingredients ; Organics ; Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sulfur & Selenium Compounds
MF: C22H28Cl2F3N3OS
MW: 510.44
EINECS: 205-674-1
Melting Point: 200-2020°C
Flash Point: 297.5 °C
Boiling Point: 568.3 °C at 760 mmHg
Vapour Pressure: 9.41E-14 mmHg at 25°C
Enthalpy of Vaporization: 89.73 kJ/mol
Sensitive: Hygroscopic
Following is the molecular structure of Fluphenazine Dihydrochloride (CAS NO.146-56-5) is:
Fluphenazine Dihydrochloride (CAS NO.146-56-5) can be used as Antipsychotic.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
guinea pig | LD50 | intraperitoneal | 299mg/kg (299mg/kg) | Pharmazie. Vol. 38, Pg. 749, 1983. | |
human | TDLo | oral | 2800ug/kg/2W- (2.8mg/kg) | musculoskeletal: other changes | British Medical Journal. Vol. 2, Pg. 1071, 1966. |
mouse | LD50 | intraperitoneal | 89mg/kg (89mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972. | |
mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00179, | |
mouse | LD50 | oral | 220mg/kg (220mg/kg) | "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972. |
Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: musculo-skeletal changes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl, SOx, NOx, and F−.
Hazard Codes:
Xn
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S36:Wear suitable protective clothing.
RIDADR: UN2811
RTECS: TL9800000
HazardClass: 6.1
PackingGroup: III
Fluphenazine Dihydrochloride (CAS NO.146-56-5) is a off-white solid.