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Fluphenazine hydrochloride
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Name

Fluphenazine hydrochloride

 EINECS 205-674-1
CAS No. 146-56-5 Density N/A
PSA 55.25000 LogP 5.85290
Solubility N/A Melting Point 200-202 °C
Formula C22H28Cl2F3N3OS Boiling Point 568.3 °C at 760 mmHg
Molecular Weight 510.451 Flash Point 297.5 °C
Transport Information UN 2811 Appearance Off-white solid
Safety 26-36/37/39-36 Risk Codes 36/37/38-20/21/22
Molecular Structure Molecular Structure of 146-56-5 (FLUPHENAZINE HYDROCHLORIDE) Hazard Symbols HarmfulXn
Synonyms

fluorophenazine dihydrochloride;Fluphenazine dihydrochloride;Lyorodin;Mirenil;Prolixin;Anatensol;Fluphenazindihydrochlorid;4-[3-[2-(Trifluoromethyl)-10H-phenothiazin-10-yl]propyl]-1-piperazineethanol dihydrochloride;Fluphenazine hydrochloride;fluphenazine dihydrodchloride;Tensofin;Moditen;Trancin;查看更多英文别名

 

Fluphenazine hydrochloride Synthetic route

146-56-5

fluphenazine dihydrochloride

1674-76-6

fluphenazine-sulfoxide

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In water for 0.0333333h; chemoselective reaction;70%
146-56-5

fluphenazine dihydrochloride

chloramine-T

chloramine-T

2-{4-[3-(5-oxo-2-trifluoromethyl-5H-5λ4-phenothiazin-10-yl)-propyl]-piperazin-1-yl}-ethanol; compound with GENERIC INORGANIC NEUTRAL COMPONENT

Conditions
ConditionsYield
In water at 30℃; pH=1.6; Kinetics; Further Variations:; pH-values; Temperatures; variation of ionic strength, dielectric constant of the medium + halides;
146-56-5

fluphenazine dihydrochloride

copper dichloride

81504-38-3

{C12H7NS(CF3)(CH2CH2CH2(C4H8N2)CH2CH2OH)}CuCl2(H2O)2

Conditions
ConditionsYield
In acetone soln. of CuCl2 in acetone mixed with soln. of organic compound in acetone, benzene added, mixture concentrated on a heating mantle at 60-70°C; filtered, washed with benzene followed by ether, dried in vac.; elem. anal.;
146-56-5

fluphenazine dihydrochloride

88-89-1

2,4,6-Trinitrophenol

2C6H3N3O7*C22H26F3N3OS

Conditions
ConditionsYield
In methanol at 59.84℃; for 1h;

Fluphenazine hydrochloride Chemical Properties

Chemistry informtion about Fluphenazine Dihydrochloride (CAS NO.146-56-5) is:
IUPAC Name: 2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethanol dihydrochloride
Synonyms: 10-(3-(4-(2-Hydroxyethyl)Piperazinyl)Propyl)-2-Trifluoromethylphenothiazine ; 4-(3-(2-(Trifluoromethyl)Phenothiazin-10-Yl)Propyl)-1-Piperazineethanodihy ; 4-(3-(2-(Trifluoromethyl)Phenothiazin-10-Yl)Propyl)-1-Piperazineethanol,Dihy ; 4-[3[2-(Trifluoromethyl)-10h-Phenothiazin-10-Yl]Propyl]-1-Piperazineethano ; A4077 ; Anatensol ; Flufenazin ; Liogen
Product Categories: Active Pharmaceutical Ingredients ; Organics ; Heterocyclic Compounds ; Heterocycles ; Intermediates & Fine Chemicals ; Pharmaceuticals ; Sulfur & Selenium Compounds 
MF: C22H28Cl2F3N3OS
MW: 510.44
EINECS: 205-674-1
Melting Point: 200-2020°C
Flash Point: 297.5 °C
Boiling Point: 568.3 °C at 760 mmHg
Vapour Pressure: 9.41E-14 mmHg at 25°C 
Enthalpy of Vaporization: 89.73 kJ/mol
Sensitive: Hygroscopic
Following is the molecular structure of Fluphenazine Dihydrochloride (CAS NO.146-56-5) is:

Fluphenazine hydrochloride Uses

Fluphenazine Dihydrochloride (CAS NO.146-56-5) can be used as Antipsychotic.

Fluphenazine hydrochloride Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 299mg/kg (299mg/kg)   Pharmazie. Vol. 38, Pg. 749, 1983.
human TDLo oral 2800ug/kg/2W- (2.8mg/kg)
musculoskeletal: other changes
 British Medical Journal. Vol. 2, Pg. 1071, 1966.
mouse LD50 intraperitoneal 89mg/kg (89mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972.
mouse LD50 intravenous 56mg/kg (56mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#00179,
mouse LD50 oral 220mg/kg (220mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 24, 1972.

Fluphenazine hydrochloride Safety Profile

Poison by ingestion, intraperitoneal, and intravenous routes. Moderately toxic by subcutaneous route. Human systemic effects by ingestion: musculo-skeletal changes. Mutation data reported. When heated to decomposition it emits very toxic fumes of HCl, SOx, NOx, and F−.  
Hazard Codes:
HarmfulXn
Risk Statements:
R36/37/38:Irritating to eyes, respiratory system and skin. 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S36:Wear suitable protective clothing.
RIDADR: UN2811
RTECS: TL9800000
HazardClass: 6.1
PackingGroup: III

Fluphenazine hydrochloride Specification

Fluphenazine Dihydrochloride (CAS NO.146-56-5) is a off-white solid.

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