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Basic Information
CAS No.: 1484-84-0
Name: 2-Piperidineethanol
Molecular Structure:
Molecular Structure of 1484-84-0 (2-Piperidineethanol)
Formula: C7H15NO
Molecular Weight: 129.202
Synonyms: 2-(2-Hydroxyethyl)piperidine;2-(2-Piperidinyl)ethanol;2-Piperidine-2-yl-ethanol;NSC 9261;
EINECS: 216-059-2
Density: 0.939 g/cm3
Melting Point: 38-40 °C(lit.)
Boiling Point: 234.5 °C at 760 mmHg
Flash Point: 102.2 °C
Solubility: soluble in water
Appearance: off-white solid
Hazard Symbols: CorrosiveC,IrritantXi
Risk Codes: 20/21/22-34-36/37/38
Safety: 26-27-28-36/37/39-45-24/25
Transport Information: UN 3263 8/PG 2
PSA: 32.26000
LogP: 0.83970
Synthetic route
103-74-2

2-(2-Hydroxyethyl)pyridine

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
With 1,4-dioxane; nickel at 160℃; under 191232 Torr; Hydrogenation;
With ethanol; nickel at 150℃; under 95616 Torr; Hydrogenation;
With acetic acid; platinum Hydrogenation;
134256-32-9, 134256-31-8, 134256-33-0, 119204-13-6

N-benzyl-2-(2-hydroxyethyl)piperidine

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
With palladium on activated charcoal; ammonium formate In methanol for 12h; Heating; Yield given;
α-picolylcarbinol

α-picolylcarbinol

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
With ethanol; sodium
α-picolyl-carbinol

α-picolyl-carbinol

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
With ethanol; sodium
110-89-4

piperidine

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 30 percent / H2O2, sodium tungstate dihydrate / methanol / under 5 deg C, then Rt, 24 h
2: CH2Cl2 / 12 h / Heating
3: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h
4: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating
View Scheme
119204-12-5

2-isobutoxyhexahydroisoxazolo<2,3-a>-pyridine

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: CH2Cl2 / 12 h / Heating
2: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h
3: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating
View Scheme
119204-19-2

(2S,3aR)-8-Benzyl-2-isobutoxy-hexahydro-isoxazolo[2,3-a]pyridin-8-ium; bromide

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h
2: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating
View Scheme
1885-14-9

phenyl chloroformate

A

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

B

3-(dimethylamino)propyl 2-[2-(hydroxyethyl)]piperidinecarboxylate

3-(dimethylamino)propyl 2-[2-(hydroxyethyl)]piperidinecarboxylate

Conditions
ConditionsYield
pyridine
1885-14-9

phenyl chloroformate

A

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

B

3-chloropropyl 2-[2-(hydroxyethyl)]piperidinecarboxylate

3-chloropropyl 2-[2-(hydroxyethyl)]piperidinecarboxylate

103-74-2

2-(2-Hydroxyethyl)pyridine

7440-18-8

ruthenium

1484-84-0

2(RS)-(2-hydroxyethyl)piperidine

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    2-Piperidineethanol CAS No. 1484-84-0 Molecular Formula C7H15NO Appearance w

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    2-Piperidineethanol

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  • 2-Piperidineethanol cas no. 1484-84-0 98%

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    2-Piperidineethanol cas no. 1484-84-0 98%

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    2-Piperidineethanol

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    2-Piperidineethanol

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    2-Piperidineethanol

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    2-Piperidineethanol

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    2-Piperidineethanol

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    2-Piperidineethanol

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Chemistry

Structure of 2-Piperidineethanol (CAS NO.1484-84-0):

IUPAC Name: 2-piperidin-2-ylethanol 
Empirical Formula: C7H15NO
Molecular Weight: 129.2001 
EINECS: 216-059-2 
Index of Refraction: 1.454
Molar Refractivity: 37.26 cm3
Molar Volume: 137.5 cm3
 Polarizability: 14.77×10-24cm3
Surface Tension: 34.6 dyne/cm
Density: 0.939 g/cm3
Flash Point: 102.2 °C
Enthalpy of Vaporization: 54.78 kJ/mol 
Melting Point: 38-40 °C(lit.)
Boiling Point: 234.5 °C at 760 mmHg
Vapour Pressure: 0.00967 mmHg at 25°C 
Water Solubility: soluble 
Physical Appearance: Off-White Solid
Product Categories: Alcohols and Derivatives;Heterocycles;Piperidine;Alkohols;Amines;Chiral Reagents 
Synonyms of 2-Piperidineethanol (CAS NO.1484-84-0): 2-(2-Hydroxyethyl)piperidine ; 2-Piperidine ethanol ; 2-Piperidin-2-ylethanol .

Uses

  2-Piperidineethanol (CAS NO.1484-84-0) is used in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases, also used in treatment and prophylaxis of HCV infection and other diseases such as cancer.

Safety Profile

Hazard Codes: CorrosiveC,IrritantXi
Risk Statements: 20/21/22-34-36/37/38 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R34:Causes burns. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-27-28-36/37/39-45-24/25 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S27:Take off immediately all contaminated clothing. 
S28:After contact with skin, wash immediately with plenty of soap-suds. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) 
S24/25:Avoid contact with skin and eyes.
RIDADR: UN 3263 8/PG 2
WGK Germany: 3