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CAS No.: | 1484-84-0 |
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Name: | 2-Piperidineethanol |
Molecular Structure: | |
Formula: | C7H15NO |
Molecular Weight: | 129.202 |
Synonyms: | 2-(2-Hydroxyethyl)piperidine;2-(2-Piperidinyl)ethanol;2-Piperidine-2-yl-ethanol;NSC 9261; |
EINECS: | 216-059-2 |
Density: | 0.939 g/cm3 |
Melting Point: | 38-40 °C(lit.) |
Boiling Point: | 234.5 °C at 760 mmHg |
Flash Point: | 102.2 °C |
Solubility: | soluble in water |
Appearance: | off-white solid |
Hazard Symbols: | C,Xi |
Risk Codes: | 20/21/22-34-36/37/38 |
Safety: | 26-27-28-36/37/39-45-24/25 |
Transport Information: | UN 3263 8/PG 2 |
PSA: | 32.26000 |
LogP: | 0.83970 |
Conditions | Yield |
---|---|
With 1,4-dioxane; nickel at 160℃; under 191232 Torr; Hydrogenation; | |
With ethanol; nickel at 150℃; under 95616 Torr; Hydrogenation; | |
With acetic acid; platinum Hydrogenation; |
N-benzyl-2-(2-hydroxyethyl)piperidine
2(RS)-(2-hydroxyethyl)piperidine
Conditions | Yield |
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With palladium on activated charcoal; ammonium formate In methanol for 12h; Heating; Yield given; |
2(RS)-(2-hydroxyethyl)piperidine
Conditions | Yield |
---|---|
With ethanol; sodium |
2(RS)-(2-hydroxyethyl)piperidine
Conditions | Yield |
---|---|
With ethanol; sodium |
Conditions | Yield |
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Multi-step reaction with 4 steps 1: 30 percent / H2O2, sodium tungstate dihydrate / methanol / under 5 deg C, then Rt, 24 h 2: CH2Cl2 / 12 h / Heating 3: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 4: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme |
2-isobutoxyhexahydroisoxazolo<2,3-a>-pyridine
2(RS)-(2-hydroxyethyl)piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: CH2Cl2 / 12 h / Heating 2: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 3: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme |
(2S,3aR)-8-Benzyl-2-isobutoxy-hexahydro-isoxazolo[2,3-a]pyridin-8-ium; bromide
2(RS)-(2-hydroxyethyl)piperidine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 94 percent / LiAlH4 / tetrahydrofuran / 0 deg C, then reflux, 3 h 2: ammonium formate, 10percent Pd/C / methanol / 12 h / Heating View Scheme |
Conditions | Yield |
---|---|
pyridine |
Structure of 2-Piperidineethanol (CAS NO.1484-84-0):
IUPAC Name: 2-piperidin-2-ylethanol
Empirical Formula: C7H15NO
Molecular Weight: 129.2001
EINECS: 216-059-2
Index of Refraction: 1.454
Molar Refractivity: 37.26 cm3
Molar Volume: 137.5 cm3
Polarizability: 14.77×10-24cm3
Surface Tension: 34.6 dyne/cm
Density: 0.939 g/cm3
Flash Point: 102.2 °C
Enthalpy of Vaporization: 54.78 kJ/mol
Melting Point: 38-40 °C(lit.)
Boiling Point: 234.5 °C at 760 mmHg
Vapour Pressure: 0.00967 mmHg at 25°C
Water Solubility: soluble
Physical Appearance: Off-White Solid
Product Categories: Alcohols and Derivatives;Heterocycles;Piperidine;Alkohols;Amines;Chiral Reagents
Synonyms of 2-Piperidineethanol (CAS NO.1484-84-0): 2-(2-Hydroxyethyl)piperidine ; 2-Piperidine ethanol ; 2-Piperidin-2-ylethanol .
2-Piperidineethanol (CAS NO.1484-84-0) is used in preparation of a novel class of pyrazolopyrimidines as inhibitors of protein and checkpoint kinases, also used in treatment and prophylaxis of HCV infection and other diseases such as cancer.
Hazard Codes: C,Xi
Risk Statements: 20/21/22-34-36/37/38
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-27-28-36/37/39-45-24/25
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S27:Take off immediately all contaminated clothing.
S28:After contact with skin, wash immediately with plenty of soap-suds.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25:Avoid contact with skin and eyes.
RIDADR: UN 3263 8/PG 2
WGK Germany: 3