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CAS No.: | 1484-85-1 |
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Name: | HOMOPIPERONYLAMINE |
Article Data: | 87 |
Molecular Structure: | |
Formula: | C9H11NO2 |
Molecular Weight: | 165.192 |
Synonyms: | Phenethylamine,3,4-(methylenedioxy)- (7CI,8CI);2-(3,4-Methylenedioxyphenyl)ethylamine;2-(Benzo[d][1,3]dioxol-5-yl)ethanamine;2-Benzo[1,3]dioxol-5-yl-ethylamine;2-Benzo[1,3]dioxol-5-ylethanamine;3,4-(Methylenedioxy)-b-phenethylamine;3,4-(Methylenedioxy)phenethylamine;3,4-(Methylenedioxy)phenylethylamine;5-(2-Aminoethyl)benzodioxole;Homopiperonylamine;[2-(Benzodioxol-5-yl)ethyl]amine; |
EINECS: | 216-060-8 |
Density: | 1.204 g/c3 |
Melting Point: | 114 °C |
Boiling Point: | 274.3 ºCat 760 mmHg |
Flash Point: | 129.8 ºC |
Appearance: | Colourless Liquid |
Hazard Symbols: | Xi |
Risk Codes: | 41 |
Safety: | 26-39-24/25 |
PSA: | 44.48000 |
LogP: | 1.61680 |
Conditions | Yield |
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With lithium aluminium tetrahydride In tetrahydrofuran at 20 - 70℃; for 4h; | 100% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; for 4h; | 95% |
With diisobutylaluminium hydride In 1,4-dioxane at 60℃; for 3h; | 82% |
benzyl N-[2-(benzo[1,3]dioxol-5-yl)ethyl]carbamate
3,4-methylenedioxyphenylethylamine
Conditions | Yield |
---|---|
With hydrogen; palladium on activated charcoal In tetrahydrofuran; methanol at 20℃; under 760 Torr; for 3h; | 100% |
3,4-methylenedioxyphenylethylamine
Conditions | Yield |
---|---|
With hydrogen In ethanol at 70℃; under 112511 Torr; for 6h; Green chemistry; | 95.6% |
5-((E)-2-nitroethenyl)-1,3-benzodioxole
3,4-methylenedioxyphenylethylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In tetrahydrofuran; diethyl ether at 0 - 70℃; for 12h; Inert atmosphere; | 95% |
With lithium aluminium tetrahydride In tetrahydrofuran Reflux; | 87% |
With lithium aluminium tetrahydride In tetrahydrofuran at 0℃; Reflux; | 84% |
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride; aluminium trichloride In diethyl ether for 2h; | 92% |
With diisobutylaluminium hydride In tetrahydrofuran at 60℃; for 3h; Product distribution; other solvent, temp., time, reagent; | 80% |
With diisobutylaluminium hydride In tetrahydrofuran at 60℃; for 3h; | 80% |
3-(benzo[d][1,3]dioxol-5-yl)propanamide
3,4-methylenedioxyphenylethylamine
Conditions | Yield |
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With chlorine; sodium hydroxide In water at -5 - 40℃; for 4h; Reagent/catalyst; Temperature; | 91% |
With chlorine; sodium hydroxide at 30 - 75℃; for 2h; Green chemistry; | 90% |
With sodium hydroxide; bromine In water at 70 - 80℃; for 0.25h; | 71% |
With sodium hypochlorite at 70 - 80℃; |
5-(2-nitroethyl)benzo[1,3]dioxole
3,4-methylenedioxyphenylethylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride | 75% |
With hydrogenchloride; iron In methanol; water for 0.5h; Heating; | 71% |
With hydrogenchloride; zinc | |
With hydrogenchloride; zinc In ethanol; water for 3h; |
3,4-methylenedioxyphenylethylamine
Conditions | Yield |
---|---|
With hydrogenchloride; iron In methanol; water for 0.5h; Heating; | 70% |
benzo[1,3]dioxol-5-yl-acetaldehyde-oxime
3,4-methylenedioxyphenylethylamine
Conditions | Yield |
---|---|
With sodium amalgam; acetic acid | |
With ethanol; calcium | |
With ethanol; sodium |
α-acetoxy-2-(3,4-methylenedioxyphenyl)acetonitrile
3,4-methylenedioxyphenylethylamine
Conditions | Yield |
---|---|
With methanol; palladium; acetic acid Hydrogenation.Zusatz von wenig Salzsaeure; | |
With sulfuric acid; palladium; acetic acid Hydrogenation; |
The Molecular Structure of 1,3-Benzodioxole-5-ethanamine (CAS NO.1484-85-1):
Empirical Formula: C9H11NO2
Molecular Weight: 165.1891
EINECS: 216-060-8
IUPAC Name: 2-(1,3-Benzodioxol-5-yl)ethanamine
Appearance: Colourless Liquid
Product Categories: Pharmaceutical Intermediates; Intermediates
Nominal Mass: 165
Average Mass: 165.1891
Monoisotopic Mass: 165.078979
Index of Refraction: 1.577
Molar Refractivity: 45.49 cm3
Molar Volume: 137.1 cm3
Surface Tension: 52 dyne/cm
Density: 1.204 g/cm3
Flash Point: 129.8 °C
Enthalpy of Vaporization: 51.27 kJ/mol
Boiling Point: 274.3 °C at 760 mmHg
Vapour Pressure: 0.00543 mmHg at 25 °C
1,3-Benzodioxole-5-ethanamine (CAS NO.1484-85-1) is used as an intermediate in the synthesis of pharmaceutical actives and other fine chemicals.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LDLo | intraperitoneal | 300mg/kg (300mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Journal of Physiology. Vol. 76, Pg. 224, 1932. |
1,3-Benzodioxole-5-ethanamine (CAS NO.1484-85-1) is called as 2-(3,4-(Methylendioxy)phenyl)ethylamine ; 2-(3',4'-Methylenedioxy-phenyl)ethylamine ; 3,4-mde ; 3,4-Methylenedioxyphenethylamine ; 3,4-(Methylenedioxyphenyl)ethylamine ; Dl-mdea ; Homopiperonylamine .