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Basic Information
CAS No.: 152-53-4
Name: Cycloguanil Hydrochloride
Molecular Structure:
Molecular Structure of 152-53-4 (Cycloguanil Hydrochloride)
Formula: C11H14 Cl N5 . Cl H
Molecular Weight: 288.18
Synonyms: 1,3,5-Triazine-2,4-diamine,1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-, monohydrochloride (9CI);s-Triazine, 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-,hydrochloride (6CI); s-Triazine,4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-, monohydrochloride(8CI); 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diaminemonohydrochloride; BN 2410; Chlorcycloguanil; Chloroguanide triazinehydrochloride; Cycloguanil hydrochloride; NSC 3074
Density: g/cm3
Melting Point: 210-2150C
Boiling Point: 400.7°Cat760mmHg
Flash Point: 196.1°C
Safety: Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and Cl.
PSA: 80.00000
LogP: 2.66430
Synthetic route
4022-81-5, 55307-40-9

1-(4-chlorophenyl)biguanide hydrochloride

67-64-1

acetone

152-53-4

cycloguanil hydrochloride

Conditions
ConditionsYield
With hydrogenchloride; Triethyl orthoacetate In methanol at 20℃;69%
106-47-8

4-chloro-aniline

127099-85-8, 780722-26-1

N-Cyanoguanidine

67-64-1

acetone

152-53-4

cycloguanil hydrochloride

Conditions
ConditionsYield
With hydrogenchloride Cyclocondensation;62%
With hydrogenchloride In water Reflux;
106-47-8

4-chloro-aniline

67-64-1

acetone

152-53-4

cycloguanil hydrochloride

Conditions
ConditionsYield
With hydrogenchloride for 24h; Heating;31%
152-53-4

cycloguanil hydrochloride

5405-65-2

N2-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine

Conditions
ConditionsYield
In pyridine; ethanol for 12h; Heating;95%
With sodium hydroxide In ethanol; water for 1h; pH=11; Dimroth rearrangement; Reflux;2.11 g
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  • 152-53-4  CAS NO.152-53-4

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    Cycloguanil Hydrochloride

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    Cycloguanil hydrochloride

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Chemistry

Empirical Formula: C11H15Cl2N5
Molecular Weight: 288.1763 
Flash Point: 196.1 °C
Enthalpy of Vaporization: 65.16 kJ/mol
Boiling Point: 400.7 °C at 760 mmHg
Vapour Pressure: 1.25E-06 mmHg at 25 °C
Melting point: 210-215 °C
Appearance: Crystalline solid
Product categories of Cycloguanil hydrochloride (CAS NO.152-53-4): Aromatics Compounds;Aromatics;Nucleotides;Bases & Related Reagents;Pharmaceuticals;Isotope Labeled Compounds;Heterocycles;Intermediates & Fine Chemicals
Structure of Cycloguanil hydrochloride (CAS NO.152-53-4):
                 

Uses

Cycloguanil hydrochloride (CAS NO.152-53-4) has been used for labelled antimalarial drug.

Toxicity Data With Reference

1.    

ipr-mus LD50:54 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),487.
2.    

scu-mus LD50:220 mg/kg

    ATMPA2    Annals of Tropical Medicine and Parasitology. 74 (1980),393.
3.    

ivn-dog LDLo:24 mg/kg

    TXAPA9    Toxicology and Applied Pharmacology. 18 (1971),487.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and Cl.

Specification

 Cycloguanil hydrochloride ,its cas register number is 152-53-4. It also can be called Chlorcycloguanil ; s-Triazine, 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-, monohydrochloride or 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride .