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CAS No.: | 152-53-4 |
---|---|
Name: | Cycloguanil Hydrochloride |
Article Data: | 4 |
Molecular Structure: | |
Formula: | C11H14 Cl N5 . Cl H |
Molecular Weight: | 288.18 |
Synonyms: | 1,3,5-Triazine-2,4-diamine,1-(4-chlorophenyl)-1,6-dihydro-6,6-dimethyl-, monohydrochloride (9CI);s-Triazine, 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-,hydrochloride (6CI); s-Triazine,4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-, monohydrochloride(8CI); 1-(4-Chlorophenyl)-1,6-dihydro-6,6-dimethyl-1,3,5-triazine-2,4-diaminemonohydrochloride; BN 2410; Chlorcycloguanil; Chloroguanide triazinehydrochloride; Cycloguanil hydrochloride; NSC 3074 |
Density: | g/cm3 |
Melting Point: | 210-2150C |
Boiling Point: | 400.7°Cat760mmHg |
Flash Point: | 196.1°C |
Safety: | Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and Cl−. |
PSA: | 80.00000 |
LogP: | 2.66430 |
1-(4-chlorophenyl)biguanide hydrochloride
acetone
cycloguanil hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride; Triethyl orthoacetate In methanol at 20℃; | 69% |
4-chloro-aniline
N-Cyanoguanidine
acetone
cycloguanil hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride Cyclocondensation; | 62% |
With hydrogenchloride In water Reflux; |
dicyandiamide
4-chloro-aniline
acetone
cycloguanil hydrochloride
Conditions | Yield |
---|---|
With hydrogenchloride for 24h; Heating; | 31% |
cycloguanil hydrochloride
N2-(4-chloro-phenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine
Conditions | Yield |
---|---|
In pyridine; ethanol for 12h; Heating; | 95% |
With sodium hydroxide In ethanol; water for 1h; pH=11; Dimroth rearrangement; Reflux; | 2.11 g |
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Empirical Formula: C11H15Cl2N5
Molecular Weight: 288.1763
Flash Point: 196.1 °C
Enthalpy of Vaporization: 65.16 kJ/mol
Boiling Point: 400.7 °C at 760 mmHg
Vapour Pressure: 1.25E-06 mmHg at 25 °C
Melting point: 210-215 °C
Appearance: Crystalline solid
Product categories of Cycloguanil hydrochloride (CAS NO.152-53-4): Aromatics Compounds;Aromatics;Nucleotides;Bases & Related Reagents;Pharmaceuticals;Isotope Labeled Compounds;Heterocycles;Intermediates & Fine Chemicals
Structure of Cycloguanil hydrochloride (CAS NO.152-53-4):
Cycloguanil hydrochloride (CAS NO.152-53-4) has been used for labelled antimalarial drug.
1. | ipr-mus LD50:54 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),487. | ||
2. | scu-mus LD50:220 mg/kg | ATMPA2 Annals of Tropical Medicine and Parasitology. 74 (1980),393. | ||
3. | ivn-dog LDLo:24 mg/kg | TXAPA9 Toxicology and Applied Pharmacology. 18 (1971),487. |
Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx and Cl−.
Cycloguanil hydrochloride ,its cas register number is 152-53-4. It also can be called Chlorcycloguanil ; s-Triazine, 4,6-diamino-1-(p-chlorophenyl)-1,2-dihydro-2,2-dimethyl-, monohydrochloride or 1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine hydrochloride .