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CAS No.: | 1535-75-7 |
---|---|
Name: | 2-(Trifluoromethoxy)aniline |
Article Data: | 5 |
Molecular Structure: | |
Formula: | C7H6F3NO |
Molecular Weight: | 177.126 |
Synonyms: | o-Anisidine,a,a,a-trifluoro- (6CI,7CI,8CI);2-(Trifluoromethoxy)benzenamine;2-Trifluoromethoxyaniline;o-(Trifluoromethoxy)aniline; |
EINECS: | 216-257-9 |
Density: | 1.301 g/cm3 |
Boiling Point: | 170.2 °C at 760 mmHg |
Flash Point: | 56.7 °C |
Appearance: | clear, very faintly yellow liquid |
Hazard Symbols: | Xn,T,Xi |
Risk Codes: | 36/37/38-20/21/22-10 |
Safety: | 36/37/39-26-45-16 |
Transport Information: | UN 1993 |
PSA: | 35.25000 |
LogP: | 2.74860 |
1-bromo-2-(trifluoromethoxy)benzene
2-trifluoromethoxy aniline
Conditions | Yield |
---|---|
With ammonium hydroxide; L-2-O-methyl-chiro-inositol; copper(II) acetate monohydrate In 1-methyl-pyrrolidin-2-one at 110℃; for 12h; | 82% |
1-chloro-4-(trifluoromethoxy)benzene
A
2-trifluoromethoxy aniline
B
m-trifluoromethoxyaniline
Conditions | Yield |
---|---|
Stage #1: 1-chloro-4-(trifluoromethoxy)benzene With sulfuric acid; nitric acid at 0 - 45℃; Stage #2: With palladium on activated charcoal; hydrogen; triethylamine In methanol at 80℃; under 15001.5 Torr; Temperature; Pressure; Autoclave; Overall yield = 98 percent; Overall yield = 177.12 g; |
2-trifluoromethoxy aniline
2-(trifluoromethoxy)benzenesulfonyl chloride
2-trifluoromethoxy-benzenesulphonic acid amide
Conditions | Yield |
---|---|
99.4% |
di-tert-butyl dicarbonate
2-trifluoromethoxy aniline
tert-butyl N-[2-(trifluoromethoxy)phenyl]carbamate
Conditions | Yield |
---|---|
In toluene at 100℃; for 2h; | 98% |
In toluene Heating; | 76% |
2-trifluoromethoxy aniline
ethyl acetoacetate
3-oxo-2-(2-(2-(trifluoromethoxy)phenyl)hydrazono)butanoic acid ethyl ester
Conditions | Yield |
---|---|
Stage #1: 2-trifluoromethoxy aniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.5h; Stage #2: ethyl acetoacetate With sodium acetate In ethanol; water at 0℃; | 92.3% |
Stage #1: 2-trifluoromethoxy aniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.0833333h; Stage #2: ethyl acetoacetate With ammonium acetate In ethanol; water | |
Stage #1: 2-trifluoromethoxy aniline With hydrogenchloride; sodium nitrite In water at 0℃; for 0.0833333h; Stage #2: ethyl acetoacetate With ammonium acetate In ethanol; water at 0℃; for 0.5h; |
2-trifluoromethoxy aniline
t-butyl 2-diazopropanoate
Conditions | Yield |
---|---|
With C32H30N4O4; copper(l) chloride In dichloromethane at 0℃; for 18h; Inert atmosphere; Molecular sieve; optical yield given as %ee; enantioselective reaction; | 92% |
Conditions | Yield |
---|---|
With formic acid for 12h; Reflux; | 90.56% |
Conditions | Yield |
---|---|
Stage #1: 2-trifluoromethoxy aniline With hydrogenchloride; sodium nitrite In ethanol; water at 0 - 5℃; for 0.5h; Stage #2: ethyl 2-chloro-3-oxo-butyrate With sodium acetate In ethanol; water at 0 - 25℃; | 90% |
2-trifluoromethoxy aniline
Conditions | Yield |
---|---|
With sodium nitrite In hydrogenchloride; water | 88% |
ortho-nitrobenzoic acid
2-trifluoromethoxy aniline
2-nitro-N-(2-(trifluoromethoxy)phenyl)benzamide
Conditions | Yield |
---|---|
Stage #1: ortho-nitrobenzoic acid With thionyl chloride In N,N-dimethyl-formamide; benzene Reflux; Stage #2: 2-trifluoromethoxy aniline With triethylamine In dichloromethane; N,N-dimethyl-formamide at 0 - 20℃; | 88% |
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