CAS No.154323-57-6,Almotriptan Suppliers

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Basic Information

Molecular Structure:
CAS No.:	154323-57-6
Name:	Almotriptan
Article Data:	10

Formula:	C₁₇H₂₅N₃O₂S
Molecular Weight:	335.47
Synonyms:	Pyrrolidine,1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]- (9CI);Almogran;N,N-Dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]-ethanamine;
EINECS:	1312995-182-4
Density:	1.27 g/cm³
Melting Point:	170-172°C
Boiling Point:	538.7 °C at 760 mmHg
Flash Point:	279.6 °C
Appearance:	light yellow or white power
PSA:	64.79000
LogP:	3.21630

Raw Materials

50-00-0

334981-30-5

Downstream Products

181183-52-8

Total:102 Page 1 of 3 1 2 3 Next>>

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Chemistry

Molecular Structure of Almotriptan (CAS NO.154323-57-6):

IUPAC Name: N,N-dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethanamine
Molecular Formula: C₁₇H₂₅N₃O₂S
Molar mass: 335.4643 g/mol
Density: 1.27 g/cm³
Flash Point: 279.6 °C
Index of Refraction: 1.633
Boiling Point: 538.7 °C at 760 mmHg
Vapour Pressure: 1.13E-11 mmHg at 25°C
XLogP3-AA: 1.6
H-Bond Donor: 1
H-Bond Acceptor: 4
H bond acceptors: 5
Freely Rotating Bonds: 6
Polar Surface Area: 53.93 Å²
InChI
InChI=1/C17H25N3O2S/c1-19(2)10-7-15-12-18-17-6-5-14(11-16(15)17)13-23(21,22)20-8-3-4-9-20/h5-6,11-12,18H,3-4,7-10,13H2,1-2H3
Smiles
c1c(cc2c(c[nH]c2c1)CCN(C)C)CS(N1CCCC1)(=O)=O
Product Categories: Heterocyclic Compounds; Intermediates & Fine Chemicals; Isotope Labeled Compounds; Pharmaceuticals; APIs
Synonyms: Pyrrolidine,1-[[[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]- (9CI) ; Almotriptan malate

Specification

Almotriptan (154323-57-6), which also can be called for Almogran ; 1-[[[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine ; N,N-Dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]-ethanamine , it is a triptan drug discovered by Almirall Prodesfarma and licensed to Ortho-McNeil for the treatment of migraine headaches. It is available in strengths of 6.25 and 12.5 mg as a tablet and is indicated for the acute treatment of migraine with or without aura in adults.

In the United States and Canada Almotriptan is available under the name Axert only by prescription. Axert for oral administration contains almotriptan malate equivalent to 6.25 or 12.5 mg of almotriptan. Each compressed tablet contains the following inactive ingredients: cellulose, mannitol, povidone, sodium stearyl fumarate, sodium starch glycolate, titanium dioxide, polyethylene glycol, hypromellose, propylene glycol, iron oxide (6.25 mg only), FD & C Blue No. 2 (12.5 mg only), and carnauba wax. The brand Almogran is used in Belgium, France, Finland, Italy, Portugal, the United Kingdom and Spain. Each 12.5 mg. tablet contains the following inactive ingredients: carnauba wax, indigo carmine (E132), hypromellose, macrogol 400, microcrystalline cellulose, mannitol, povidone, sodium starch glycollate, propylene glycol, titanium dioxide (E171) and sodium stearyl fumarate.