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CAS No.: | 192775-97-6 |
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Name: | 2-[1-(4-BROMOPHENYL)-1-METHYLETHYL]-4,4-DIMETHYL-4,5-DIHYDROOXAZOLINE |
Article Data: | 2 |
Molecular Structure: | |
Formula: | C14H18BrNO |
Molecular Weight: | 296.207 |
Synonyms: | QC-2699; |
Density: | 1.27g/cm3 |
Boiling Point: | 346.1oC at 760 mmHg |
Flash Point: | 163.1oC |
PSA: | 21.59000 |
LogP: | 3.36960 |
4-bromo-α-(4,4-dimethyloxazolin-2-yl)toluene
methyl iodide
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
Conditions | Yield |
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With CH3I; potassium hexamethylsilazane; acetic acid In dichloromethane; water; isopropyl alcohol | 4.61 g (0.0156 mmole, 84%) |
2-(4-bromophenyl)-2-methylpropionic acid
2-Amino-2-methyl-1-propanol
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
Conditions | Yield |
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Stage #1: 2-(4-bromophenyl)-2-methylpropionic acid With thionyl chloride Stage #2: 2-Amino-2-methyl-1-propanol With thionyl chloride |
(4-bromo-phenyl)-acetic acid methyl ester
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
Conditions | Yield |
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Multi-step reaction with 2 steps 1: sodium hydride 2: thionyl chloride View Scheme |
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
4-Chlorobutyronitrile
4-(4-chloro-1-oxobutyl)-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
Conditions | Yield |
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With iodine; magnesium In tetrahydrofuran | 93% |
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
tri-n-butyl(vinyl)tin
4,4-dimethyl-2-(2-(4-vinylphenyl)propan-2-yl)-4,5-dihydrooxazole
Conditions | Yield |
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With tetrakis(triphenylphosphine) palladium(0); lithium chloride In N,N-dimethyl-formamide at 70℃; Stille coupling; Inert atmosphere; | 82% |
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
4-Chlorobutanoyl chloride
4-(4-chloro-1-oxobutyl)-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
Conditions | Yield |
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With n-butyllithium In tetrahydrofuran |
oxirane
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
2-(4-piperidinyl)-1H-benzimidazole
Conditions | Yield |
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Stage #1: oxirane; 4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene With n-butyllithium Stage #2: 2-(4-piperidinyl)-1H-benzimidazole |
oxirane
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
p-toluenesulfonyl chloride
Conditions | Yield |
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With n-butyllithium |
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: n-butyllithium View Scheme |
4-bromo-α,α-dimethyl-α-(4,4-dimethyloxazolin-2-yl) toluene
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: n-butyllithium / tert-butyl methyl ether; hexane / 10 h / -60 °C / Large scale 1.2: 7 h / -60 - 20 °C / Large scale 2.1: phosphoric acid / water / 30 h / 90 °C / Large scale View Scheme |