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2062-78-4

Basic Information
CAS No.: 2062-78-4
Name: 2H-Benzimidazol-2-one,1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-
Molecular Structure:
Molecular Structure of 2062-78-4 (2H-Benzimidazol-2-one,1-[1-[4,4-bis(4-fluorophenyl)butyl]-4-piperidinyl]-1,3-dihydro-)
Formula: C28H29 F2 N3 O
Molecular Weight: 461.60
Synonyms: 2-Benzimidazolinone,1-[1-[4,4-bis(p-fluorophenyl)butyl]-4-piperidyl]- (7CI,8CI);1-(1-(4,4-Bis(4-fluorophenyl)butyl)-4-piperindinyl)-1,3-dihydro-2H-benzimidazol-2-one;1-[1-[4,4-Bis(p-fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone;1-[4,4-Bis(p-fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine; NSC170984; Orap; Pimozide; Primozide; R 6238
EINECS:
Density: 1.224g/cm3
Melting Point: 214-218°
Boiling Point: °Cat760mmHg
Flash Point: °C
Solubility: 2.9mg/L(30 oC)
Appearance:
Hazard Symbols:
Risk Codes: 22
Safety: Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and F.
Transport Information:
PSA: 41.03000
LogP: 5.79490
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    PIMOZIDE

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    Henan Sunlake Enterprise Corporation is located in Henan Province , the central plain of China , which enjoys favorable geogeaphical position and convenient transportion. The compa

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  • Pimozide

  • Casno:

    2062-78-4

    Pimozide

    Min.Order: 1 Gram

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  • Pimozide

  • Casno:

    2062-78-4

    Pimozide

    Min.Order: 0 Metric Ton

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    99% Pimozide

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Chemistry

IUPAC Name: 3-[1-[4,4-bis(4-Fluorophenyl)butyl]piperidin-4-yl]-1H-benzimidazol-2-one
Synonyms: 1-[1-[4,4-Bis(p-Fluorophenyl)butyl]-4-piperidyl]-2-benzimidazolinone ; 1-[4,4-Di-(4-Fluorophenyl)butyl]-4-(2-oxo-1-benzimidazolinyl)piperidine ; 1-{1-[4,4-Bis(4-Fluorophenyl)butyl]-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one ; 1-{1-[4,4-bis(4-Fluorophenyl)butyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
Product Categories: Organics;Dopamine receptor
CAS NO: 2062-78-4
Molecular Formula of Pimozide (CAS NO.2062-78-4) :C28H29F2N3O
Molecular Weight of Pimozide (CAS NO.2062-78-4) :461.55
Molecular structure of Pimozide (CAS NO.2062-78-4) :
EINECS: 218-171-7
Index of Refraction: 1.596
Surface Tension: 47.2 dyne/cm
Density: 1.224 g/cm3
Storage temp: 2-8°C
Solubility : DMSO: 18 mg/mL

Uses

 Pimozide (CAS NO.2062-78-4) is used in its oral preparation in schizophrenia and chronic psychosis (on-label indications in Europe only), Tourette syndrome and resistant tics (Europe, USA and Canada). In Germany the 1mg tablet is indicated for the treatment of some forms of reactive depression.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 intravenous 32mg/kg (32mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
dog LD50 oral 40mg/kg (40mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
guinea pig LD50 oral 189mg/kg (189mg/kg) BEHAVIORAL: TREMOR

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 261, 1968.
man TDLo oral 7714ug/kg/15W (7.714mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: FLUID INTAKE

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
Journal of Clinical Pyschopharmacology. Vol. 12, Pg. 140, 1992.
mouse LD50 intraperitoneal 1070mg/kg (1070mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
mouse LD50 intravenous 14mg/kg (14mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 288, 1972.
mouse LD50 oral 228mg/kg (228mg/kg) BEHAVIORAL: ATAXIA Collection of Czechoslovak Chemical Communications. Vol. 42, Pg. 1179, 1977.
mouse LD50 subcutaneous > 16gm/kg (16000mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972.
rabbit LD50 intravenous 22mg/kg (22mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rabbit LD50 oral 40mg/kg (40mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 intraperitoneal 350mg/kg (350mg/kg)   Drugs in Japan Vol. 6, Pg. 639, 1982.
rat LD50 intravenous 90mg/kg (90mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 5, Pg. 106, 1974.
rat LD50 oral 1100mg/kg (1100mg/kg)   Drugs in Japan Vol. 6, Pg. 639, 1982.
rat LD50 subcutaneous > 11gm/kg (11000mg/kg) BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE
Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 629, 1972.

Safety Profile

Poison by ingestion, intravenous, and intraperitoneal routes. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and F.
Hazard Codes HarmfulXn
Risk Statements 22
R22:Harmful if swallowed.
Safety Statements 36
S36:Wear suitable protective clothing.
RIDADR 3249
WGK Germany 3
RTECS DE1750000
HazardClass 6.1(b)
PackingGroup III

Specification

Contraindications and precautions:
1.Contraindicated in patients taking citalopram (Celexa) and escitalopram (Lexapro) due to prolongation of the QTc interval, as per the FDA.
2.Patients with prominent agitation or anxiety
3.Depressed patients
4.Severe intoxication with alcohol, opiates, and psychoactive drugs (e.g. antidepressants, benzodiazepines)
5.Preexisting Parkinson's disease
6.Comedication with nefazodone, clarithromycin and vetoconazol (see below under interactions)
7.Caution: Anticonvulsive treatment in epileptic patients should not be interrupted. Pimozide may in principle lower the seizure-threshold.
8.Caution: Patients under 18 yrs. of age. Side-effects may be particularly frequent and severe. Treatment should be started with low initial dose and the dose increased very slowly.