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208110-81-0

Basic Information
CAS No.: 208110-81-0
Name: 2-Fluoro-6-formylpyridine
Article Data: 8
Molecular Structure:
Molecular Structure of 208110-81-0 (2-Fluoro-6-formylpyridine)
Formula: C6H4FNO
Molecular Weight: 125.102
Synonyms: 6-Fluoro-2-pyridinecarboxaldehyde;6-Fluoropyridine-2-carbaldehyde;
Density: 1.27 g/cm3
Boiling Point: 192.378 °C at 760 mmHg
Flash Point: 70.148 °C
Hazard Symbols: IrritantXi, FlammableF
Risk Codes: 10-36/37/38
Safety: 16-26-36
PSA: 29.96000
LogP: 1.03320
Synthetic route
455-71-0

methyl 6-fluoropyridine-2-carboxylate

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

Conditions
ConditionsYield
With diisobutylaluminium hydride In dichloromethane at -55℃; for 3h; Inert atmosphere;84%
64197-03-1

6-fluoropyridine-2-carbonyl chloride

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

Conditions
ConditionsYield
With Pd-BaSO4; hydrogen Rosenmund reduction;68%
1243694-61-2

2-fluoro-6-(dibromomethyl)pyridine

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

Conditions
ConditionsYield
With silver nitrate In water; acetonitrile at 20℃; for 3h;60%
407-22-7

2-fluoro-6-methylpyridine

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

Conditions
ConditionsYield
With sodium periodate; tert-Butoxybis(dimethylamino)methane 1.) 140 deg C, 24 h, 2.) H2O, 25 deg C, p = 80 mbar; Yield given; Multistep reaction;
With sodium periodate; n-butyllithium; diisopropylamine In tetrahydrofuran; water
Multi-step reaction with 3 steps
1: potassium permanganate / water / Reflux
2: thionyl chloride
3: Pd-BaSO4; hydrogen
View Scheme
With sodium periodate; n-butyllithium; diisopropylamine In tetrahydrofuran; water
Stage #1: 2-fluoro-6-methylpyridine With n-butyllithium; diisopropylamine; N,N-dimethyl-formamide In tetrahydrofuran; hexanes at -78 - 0℃; for 1.75h;
Stage #2: With sodium periodate In tetrahydrofuran; hexanes; water at 0 - 20℃; for 25h;
407-22-7

2-fluoro-6-methylpyridine

5815-08-7

tert-Butoxybis(dimethylamino)methane

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

Conditions
ConditionsYield
With sodium periodate In tetrahydrofuran
With sodium periodate In water
1824-81-3

2-Amino-6-methylpyridine

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: tetrafluoroboric acid; sodium nitrite / water
2: potassium permanganate / water / Reflux
3: thionyl chloride
4: Pd-BaSO4; hydrogen
View Scheme
402-69-7

6-fluoropyridine-2-carboxylic acid

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: thionyl chloride
2: Pd-BaSO4; hydrogen
View Scheme
2459-07-6

methyl pyridine-2-carboxylate

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: silver(II) fluoride / acetonitrile / 20 °C / Inert atmosphere; Autoclave
2: diisobutylaluminium hydride / dichloromethane / 3 h / -55 °C / Inert atmosphere
View Scheme
99-98-9

4-amino-N,N-dimethylaniline

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

4-(((6-fluoropyridin-2-yl)methylene)amino)-N,N-dimethylaniline

Conditions
ConditionsYield
With sodium sulfate In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Schlenk technique;100%
579-66-8

2,6-diethylaniline

208110-81-0

2-Fluoropyridine-6-carboxaldehyde

C16H17FN2

Conditions
ConditionsYield
In ethanol at 80℃; for 12h; Inert atmosphere;97%
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Chemistry

The molecular formula of 2-Fluoro-6-formylpyridine(208110-81-0) is C6H4FNO  and its formula weight is  125.1.
The chemical synonyms of 2-Fluoro-6-formylpyridine(208110-81-0) are 2-FLUORO-6-FORMYLPYRIDINE;CHEMPACIFIC 38134;6-Fluoropyridine-2-carboxalehyde;6-FLUORO-PYRIDINE-2-CARBALDEHYDE;6-Fluoropyridine-2-carboxaldehyde;2-Pyridinecarboxaldehyde,6-fluoro-(9CI);6-Fluoropicolinaldehyde;6-FLUOROPICOLINALDEHYDE,98.5%
The molecular structure of 2-Fluoro-6-formylpyridine(208110-81-0):

Safety Profile

Hazard Codes  Xi,F
Risk Statements  10-36/37/38
Safety Statements  16-26-36