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CAS No.: | 219823-47-9 |
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Name: | R)-3-(p-toluenesulfonyl) oxytetrahydrofuran |
Article Data: | 24 |
Molecular Structure: | |
Formula: | C11H14O4S |
Molecular Weight: | 242.296 |
Synonyms: | R)-3-(p-toluenesulfonyl) oxytetrahydrofuran;(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate;(R)-Toluene-4-sulfonic acid tetrahydrofuran-3-yl ester;(3R)-Tetrahydrofuran-3-yl 4-methylbenzenesulfonate;toluene-4-sulfonic acid (R)-(tetrahydro-furan- 3-yl) ester |
EINECS: | -0 |
Density: | 1.30±0.1 g/cm3(Predicted) |
Boiling Point: | 384.8±35.0 °C(Predicted) |
PSA: | 60.98000 |
LogP: | 2.57000 |
(R)-3-Hydroxytetrahydrofuran
p-toluenesulfonyl chloride
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
Conditions | Yield |
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With pyridine In dichloromethane at 0 - 20℃; for 18h; Inert atmosphere; | 100% |
With potassium iodide; silver(l) oxide In dichloromethane at 40℃; | 89% |
Stage #1: (R)-3-Hydroxytetrahydrofuran With trimethylamine hydrochloride; triethylamine In dichloromethane at 20℃; for 0.333333h; Stage #2: p-toluenesulfonyl chloride In dichloromethane at 20℃; | 83% |
4'-hydroxy-biphenyl-4-carboxylic acid (R)-1-methyl-heptyl ester
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
4'-[(R)-(tetrahydro-furan-3-yl)oxy]-biphenyl-4-carboxylic acid (R)-1-methyl-heptyl ester
Conditions | Yield |
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With caesium carbonate In N,N-dimethyl-formamide at 60℃; for 4h; | 91.7% |
4-ethoxycarbonylpyrazole
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
C10H14N2O3
Conditions | Yield |
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With caesium carbonate In N,N-dimethyl-formamide at 80℃; for 14h; | 91% |
4-bromo-phenol
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
(S)-3-(4-bromophenoxy)tetrahydrofuran
Conditions | Yield |
---|---|
With potassium carbonate In N,N-dimethyl-formamide at 100℃; for 10h; | 90.1% |
With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 15h; |
(2-chloro-5-iodophenyl)(4-hydroxyphenyl)methanone
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
(S)-(2-chloro-5-iodophenyl)(4-((tetrahydrofuran-3-yl)oxy)phenyl)methanone
Conditions | Yield |
---|---|
With potassium carbonate; potassium iodide In acetonitrile at 50 - 55℃; | 87% |
(2R,3R,4R,5S,6S)-2-(acetoxymethyl)-6-(4-chloro-3-(4-hydroxybenzyl)phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
Conditions | Yield |
---|---|
With potassium carbonate In acetonitrile at 20℃; | 87% |
(R)-tert-butyl (2-(5-(2-fluoro-3-hydroxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-2,3-dihydropyrimidine-1(6H)-yl)-1-phenylethyl)carbamate
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl-formamide at 70℃; for 12h; | 87% |
C28H30O11
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
Conditions | Yield |
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With caesium carbonate In N,N-dimethyl-formamide at 20℃; for 12h; | 79% |
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
Conditions | Yield |
---|---|
With caesium carbonate In N,N-dimethyl acetamide at 60℃; for 2h; Inert atmosphere; | 77.9% |
With caesium carbonate In N,N-dimethyl acetamide; water at 60℃; for 2h; | 77.9% |
(R)-tetrahydrofuran-3-yl 4-methylbenzenesulfonate
Conditions | Yield |
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With N-ethyl-N,N-diisopropylamine In acetonitrile at 95℃; for 48h; | 76% |