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CAS No.: | 2516-47-4 |
---|---|
Name: | Aminomethylcyclopropane |
Article Data: | 18 |
Molecular Structure: | |
Formula: | C4H9N |
Molecular Weight: | 71.1222 |
Synonyms: | Cyclopropanemethylamine(6CI,7CI,8CI);(Cyclopropylmethyl)amine;1-Cyclopropylmethanamine;Cyclopropanemethanamine;C-Cyclopropylmethylamine;Cyclopropylmethanamine;N-(Cyclopropylmethyl)amine; |
EINECS: | 219-737-6 |
Density: | 0.912 g/cm3 |
Boiling Point: | 86.1 °C at 760 mmHg |
Flash Point: | -23 °F |
Solubility: | Fully miscible in water. |
Appearance: | clear colourless to slightly yellow liquid |
Hazard Symbols: | F, C |
Risk Codes: | 11-34 |
Safety: | 16-26-36/37/39-45-24/25 |
Transport Information: | UN 2733 3/PG 2 |
PSA: | 26.02000 |
LogP: | 1.05540 |
Cyprazepam
A
6-Chlor-2-methyl-4-phenyl-3,4-dihydrochinazolin
B
cyclopropanemethylamine
Conditions | Yield |
---|---|
In methanol; water for 14h; Mechanism; cathodic reduction, -1.480 V, Hg cathode, acetate buffer; | A 80% B n/a |
Conditions | Yield |
---|---|
bis(benzonitrile)palladium(II) dichloride In diethyl ether; dichloromethane at 5 - 10℃; for 0.5h; | 65% |
With bis(benzonitrile)palladium(II) dichloride In dichloromethane at 0 - 10℃; Yield given; |
diazomethane
1-amino-2-propene
A
1-cyclopropyl-but-3-en-1-ol
B
1-cyclopropylbut-3-en-2-ol
C
cyclopropanemethylamine
Conditions | Yield |
---|---|
bis(benzonitrile)palladium(II) dichloride In dichloromethane at 0 - 10℃; | A 31% B 10% C 65% |
Conditions | Yield |
---|---|
With sodium tetrahydroborate; nickel dichloride In tetrahydrofuran at 25℃; for 16h; Temperature; Inert atmosphere; Large scale; | 53% |
With ethanol; sodium | |
With sodium ethanolate In ethanol | |
With lithium aluminium tetrahydride In tetrahydrofuran for 18h; Inert atmosphere; Reflux; | |
With samarium diiodide; ammonia; water In tetrahydrofuran at 20℃; for 2h; Inert atmosphere; |
cyclopropanemethylamine
Conditions | Yield |
---|---|
With lithium aluminium tetrahydride In diethyl ether |
cyclopropanemethylamine
Conditions | Yield |
---|---|
With trifluoroacetic acid for 3h; |
cyclopropanemethylamine
fenoxaprop-p-ethyl
B
(R)-2-(4-hydroxyphenoxy)propionic acid ethyl ester
Conditions | Yield |
---|---|
at 20℃; | A 100% B n/a |
pyridine-4-carbaldehyde
cyclopropanemethylamine
pyridine-4-carboxaldehyde cyclopropylmethylimine
Conditions | Yield |
---|---|
With magnesium sulfate | 100% |
chloroformic acid ethyl ester
cyclopropanemethylamine
ethyl (cyclopropylmethyl)carbamate
Conditions | Yield |
---|---|
Stage #1: chloroformic acid ethyl ester; cyclopropanemethylamine With triethylamine In dichloromethane at 0 - 20℃; for 2.5h; Stage #2: With hydrogenchloride In dichloromethane; water pH=3; | 100% |
With triethylamine In dichloromethane at 0 - 20℃; Inert atmosphere; | 97% |
N-tert-butyloxycarbonylpiperidin-4-one
cyclopropanemethylamine
4-(cyclopropylmethylamino)piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
With hydrogen; palladium 10% on activated carbon In tetrahydrofuran under 2068.65 Torr; for 1h; | 100% |
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 20℃; Acidic conditions; | 74% |
With sodium tris(acetoxy)borohydride; acetic acid In 1,2-dichloro-ethane at 25℃; | |
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one; cyclopropanemethylamine With sodium acetate; acetic acid In tetrahydrofuran at 20℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran at 20℃; for 15h; Stage #3: With hydrogenchloride In diethyl ether; water | |
Stage #1: N-tert-butyloxycarbonylpiperidin-4-one; cyclopropanemethylamine With sodium acetate; acetic acid In tetrahydrofuran at 20℃; for 1h; Stage #2: With sodium tris(acetoxy)borohydride In tetrahydrofuran for 15h; Stage #3: With sodium hydroxide; water |
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The CAS register number of Aminomethylcyclopropane is 2516-47-4. It also can be called as 1-Cyclopropylmethanamine and the IUPAC name about this chemical is cyclopropylmethanamine. The molecular formula about this chemical is C4H9N and the molecular weight is 71.12. It belongs to the Amines and Anilines.
Physical properties about Aminomethylcyclopropane are: (1)ACD/LogP: 0.23; (2)ACD/LogD (pH 5.5): -2.86; (3)ACD/LogD (pH 7.4): -2.52; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 1; (8)#H bond acceptors: 1; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 3.24Å2; (12)Index of Refraction: 1.477; (13)Molar Refractivity: 22.06 cm3; (14)Molar Volume: 77.9 cm3; (15)Polarizability: 8.74x10-24cm3; (16)Surface Tension: 37.9 dyne/cm; (17)Enthalpy of Vaporization: 32.64 kJ/mol; (18)Boiling Point: 86.1 °C at 760 mmHg; (19)Vapour Pressure: 67.5 mmHg at 25°C.
Preparation: this chemical can be prepared by diazomethane and allylamine. This reaction will need reagent (PhCN)2PdCl2 and solvent CH2Cl2. The reaction temperature is 0 - 10 ℃.
Uses of Aminomethylcyclopropane: it can be used to produce 1-benzyl-3-cyclopropylmethyl-thiourea with isothiocyanatomethyl-benzene at heating. This reaction will need solvent acetone with reaction time of 3 hours. The yield is about 47%.
When you are using this chemical, please be cautious about it as the following:
This chemical is highly flammable. It can react violently with water. If you want to use it, please keep away from sources of ignition, you also need avoid contact with skin and eyes. When you are using it, wear suitable protective clothing, gloves and eye/face protection. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. In case of accident or if you feel unwell, please seek medical advice immediately (show the label whenever possible.)
You can still convert the following datas into molecular structure:
(1)SMILES: NCC1CC1
(2)InChI: InChI=1/C4H9N/c5-3-4-1-2-4/h4H,1-3,5H2
(3)InChIKey: IGSKHXTUVXSOMB-UHFFFAOYAV
(4)Std. InChI: InChI=1S/C4H9N/c5-3-4-1-2-4/h4H,1-3,5H2
(5)Std. InChIKey: IGSKHXTUVXSOMB-UHFFFAOYSA-N