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CAS No.: | 279262-23-6 |
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Name: | 4-(Morpholinomethyl)phenylboronic acid |
Article Data: | 10 |
Molecular Structure: | |
Formula: | C11H16BNO3 |
Molecular Weight: | 221.064 |
Synonyms: | Boronicacid, [4-(4-morpholinylmethyl)phenyl]- (9CI);[4-(Morpholinomethyl)phenyl]boronic acid;boronic acid, B-[4-(4-morpholinylmethyl)phenyl]-; |
Density: | 1.208 g/cm3 |
Melting Point: | 85 °C |
Boiling Point: | 382.268 °C at 760 mmHg |
Flash Point: | 184.989 °C |
PSA: | 52.93000 |
LogP: | -0.86350 |
morpholine
4-bromomethylphenylboronic acid
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
Stage #1: 4-bromomethylphenylboronic acid With N,N-diethanolaminomethyl polystyrene In dichloromethane at 20℃; for 1.66667h; Stage #2: morpholine In 1-methyl-pyrrolidin-2-one at 20℃; for 5h; Stage #3: In tetrahydrofuran; water at 20℃; Further stages.; | 88% |
In tetrahydrofuran for 2h; Heating / reflux; | |
With potassium carbonate In acetonitrile at 10 - 35℃; for 60h; | 449 mg |
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
With water; silica gel In ethyl acetate at 20℃; for 3h; | 87% |
(OC4H8NCH2C6H4)BN(CH3)(CH2CO2)2
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
With sodium hydroxide; water In tetrahydrofuran at 23℃; for 0.166667h; Inert atmosphere; | 76% |
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 120℃; for 0.5h; Sealed tube; Microwave irradiation; | 96% |
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,4-dioxane; water at 100℃; for 3h; Suzuki Coupling; Inert atmosphere; | 89% |
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene at 80℃; Suzuki-Miyaura Coupling; | 86.8% |
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene at 80℃; for 10h; | 76.15% |
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate at 110℃; for 0.5h; Microwave irradiation; | 86% |
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; sodium carbonate In 1,4-dioxane; water at 100℃; for 4h; Suzuki Coupling; Inert atmosphere; | 85% |
4-bromo-2-iodo-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
4-(4-morpholin-1-ylmethyl)phenylboronic acid
4-bromo-2-[4-(N-morpholinylmethyl)phenyl]-1-phenylsulfonyl-1H-pyrrolo[2,3-b]pyridine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); sodium hydrogencarbonate In water; N,N-dimethyl-formamide at 100℃; for 16h; Suzuki coupling; Inert atmosphere; | 84% |
4-(4-morpholin-1-ylmethyl)phenylboronic acid
Conditions | Yield |
---|---|
With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate In 1,4-dioxane; water at 110℃; for 0.5h; Inert atmosphere; | 82% |
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The IUPAC name of this chemical is [4-(Morpholinomethyl)phenyl]boronic acid. With the CAS registry number 279262-23-6, it is also named as Boronic acid,B-[4-(4-morpholinylmethyl)phenyl]-. In addition, the molecular formula is C11H16BNO3 and the molecular weight is 221.06. It should be stored in a cool and dry place.
Physical properties about [4-(Morpholinomethyl)phenyl]boronic acid are: (1)ACD/LogP: 0.47; (2)ACD/LogD (pH 5.5): -1 ; (3)ACD/BCF (pH 5.5): 1; (4)ACD/BCF (pH 7.4): 1; (5)ACD/KOC (pH 5.5): 2; (6)ACD/KOC (pH 7.4): 33; (7)#H bond acceptors: 4; (8)#H bond donors: 2; (9)#Freely Rotating Bonds: 5; (10)Polar Surface Area: 52.93 Å2; (11)Index of Refraction: 1.57; (12)Molar Refractivity: 60.019 cm3; (13)Molar Volume: 182.961 cm3; (14)Polarizability: 23.794 ×10-24cm3; (15)Surface Tension: 50.393 dyne/cm; (16)Density: 1.208 g/cm3; (17)Flash Point: 184.989 °C; (18)Enthalpy of Vaporization: 66.523 kJ/mol; (19)Boiling Point: 382.268 °C at 760 mmHg.
You can still convert the following datas into molecular structure:
(1)SMILES: OB(O)c1ccc(cc1)CN2CCOCC2
(2)InChI: InChI=1/C11H16BNO3/c14-12(15)11-3-1-10(2-4-11)9-13-5-7-16-8-6-13/h1-4,14-15H,5-9H2
(3)InChIKey: QPFDUULIDNELSE-UHFFFAOYAQ