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| CAS No.: | 28315-93-7 |
|---|---|
| Name: | 5-Hydroxy-1-tetralone |
| Article Data: | 21 |
| Cas Database | |
| Molecular Structure: | |
|
|
|
| Formula: | C10H10O2 |
| Molecular Weight: | 162.188 |
| Synonyms: | 1,2,3,4-Tetrahydro-1-oxo-5-hydroxynaphthalene;3,4-Dihydro-5-hydroxy-1(2H)-naphthalenone;5-Hydroxy-3,4-dihydro-1(2H)-naphthalenone;5-Hydroxy-a-tetralone;5-Hydroxytetralone;5-Hydroxy-1-tetralone; |
| EINECS: | 248-958-0 |
| Density: | 1.236 g/cm3 |
| Melting Point: | 206-209 °C(lit.) |
| Boiling Point: | 325.3 °C at 760 mmHg |
| Flash Point: | 138.1 °C |
| Appearance: | yellowish crystalline powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 22-24/25-37/39-26 |
| PSA: | 37.30000 |
| LogP: | 1.91120 |
- 283160-17-8Hexanoic acid,6-amino-3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-6-oxo-, (3S)-
- 283160-20-3Pentanoic acid,3-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-5-oxo-5-[(triphenylmethyl)amino]-,(3S)-
- 2831-60-9Ethanol,2-(2,4-dinitrophenoxy)-
- 2831-66-51,3,5-Triazine,2,4-dichloro-
- 283170-10-5L-Aspartic acid,N-[(2-propen-1-yloxy)carbonyl]-, 4-(9H-fluoren-9-ylmethyl) ester
- 283173-50-26H-Pyrrolo[4,3,2-ef][2]benzazepin-6-one,8-fluoro-1,3,4,5-tetrahydro-2-[4-[(methylamino)methyl]phenyl]-
- 283174-18-524-Norchola-1,5,20,22-tetraene-3,7-dione,14,15:21,23-diepoxy-6,11-dihydroxy-4,4,8-trimethyl-, (11b,13a,14b,15b,17a)- (9CI)
- 2831-75-66-Isoquinolinol,1,2,3,4-tetrahydro-1-[[4-[2-hydroxy-5-[[(1R)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]phenoxy]phenyl]methyl]-7-methoxy-2-methyl-,(1R)-
- 28319-72-4Androsta-3,5,9(11)-trien-17-one,3-methoxy- (8CI,9CI)
- 28319-77-9Ethanaminium,2-[[[(2R)-2,3-dihydroxypropoxy]hydroxyphosphinyl]oxy]-N,N,N-trimethyl-, innersalt
- 40771-26-4
1,2,3,4-tetrahydro-1,5-dihydroxy-naphthalene
- 28315-93-7
5-Hydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With tert.-butylhydroperoxide; zircornium(IV) n-propoxide In dichloromethane at 20℃; for 18h; | 96% |
- 83-56-7
1,5-dihydroxynaphthalene
- 28315-93-7
5-Hydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With aluminum tri-bromide; cyclohexane In various solvent(s) at 25℃; for 48h; | 88% |
| With palladium on activated charcoal; ammonium formate In water; butan-1-ol at 120℃; for 3h; Temperature; Solvent; Reagent/catalyst; Further stages; | 83.3% |
| Stage #1: 1,5-dihydroxynaphthalene With hydrogen; sodium hydroxide; palladium 10% on activated carbon In water; isopropyl alcohol at 20 - 80℃; under 5171.62 Torr; Autoclave; Stage #2: With hydrogenchloride In water pH=~ 2; | 60% |
| Stage #1: 1,5-dihydroxynaphthalene With hydrogen; sodium hydroxide; palladium 10% on activated carbon In water; isopropyl alcohol at 80℃; under 5171.62 Torr; for 20h; Autoclave; Stage #2: With hydrogenchloride In water pH=~ 2; | 60% |
| With palladium 10% on activated carbon; hydrogen; sodium hydroxide In water; isopropyl alcohol at 80℃; under 8250.83 Torr; for 24h; Autoclave; | 53% |
- 33892-75-0
5-Methoxy-1-tetralone
- 28315-93-7
5-Hydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With hydrogen bromide; acetic acid for 0.75h; Heating; | 85% |
| With 1-N-ferrocenylmethyl benzimidazole tagged polymer In N,N-dimethyl-formamide Reflux; | 82% |
| With hydrogen bromide In acetic acid for 24h; Heating; |
- 3041-17-6
4,5-dihydro-3H-benzo[b]oxepin-2-one
A
- 35387-19-0
2-hydroxybenzenebutanoic acid
B
- 28315-93-7
5-Hydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With PPA at 80℃; for 3h; | A 55% B 7% |
- 79950-42-8
2-allyl-3-hydroxy-benzaldehyde
A
- 28315-93-7
5-Hydroxy-1-tetralone
B
- 99678-01-0
4-hydroxy-2-methyl-2,3-dihydro-1H-inden-1-one
| Conditions | Yield |
|---|---|
| With acetic acid; L-proline at 120℃; for 24h; Green chemistry; | A 40% B 42% |
- 529-34-0
3,4-dihydronaphthalene-1(2H)-one
A
- 22009-38-7
7-hydroxy-1-tetralone
B
- 28315-93-7
5-Hydroxy-1-tetralone
C
- 1077-69-6
5,8-dihydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride at -40℃; for 0.5h; Mechanism; Product distribution; | A 30% B 34% C 5% |
| With dihydrogen peroxide; hydrogen fluoride; antimony pentafluoride at -40℃; for 0.5h; | A 30% B 34% C 5% |
- 91028-13-6
5,6,7,8-tetrahydronaphthalen-1-yl acetate
- 28315-93-7
5-Hydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With chromium(VI) oxide; acetic anhydride; acetic acid at 40℃; und Erhitzen des erhaltenen 5-Acetoxy-1-oxo-tetralins C12H12O3 mit wss.-aethanol.NaOH unter Wasserstoff; substances of mp: about 210 degree; |
- 13913-82-1, 42245-84-1, 42245-85-2, 89448-15-7, 89448-20-4
(4aSR,8aSR)-octahydronaphthalene-1,5-dione
- 28315-93-7
5-Hydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With potassium hydroxide substances of mp: 157 degree; |
- 28315-93-7
5-Hydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With sulfuric acid Diazotization; substances of mp: about 210 degree; |
- 28315-93-7
5-Hydroxy-1-tetralone
| Conditions | Yield |
|---|---|
| With kieselguhr; tetralin; nickel at 120 - 180℃; under 7355.08 - 14710.2 Torr; Hydrogenation; substances of mp: 157 degree; |
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Analytical Methods
HPLC(FDA Method)
Specification
1.Introduction of 5-Hydroxy-1-tetralone
5-Hydroxy-1-tetralone,with its CAS NO of 28315-93-7, is a kind of white to off-white powder. It has synonyms of 1,2,3,4-Tetrahydro-1-oxo-5-hydroxynaphthalene;3,4-Dihydro-5-hydroxy-1(2H)-naphthalenone;5-Hydroxy-3,4-dihydro-1(2H)-naphthalenone;5-Hydroxy-a-tetralone and 5-Hydroxytetralone. It is stable under normal temperatures and pressures.
2.Properties of 5-Hydroxy-1-tetralone
Surface Tension: 52.4 dyne/cmIndex of Refraction: 1.602Density: 1.236 g/cm3Flash Point: 138.1 °CEnthalpy of Vaporization: 59 kJ/molBoiling Point: 325.3 °C at 760 mmHgVapour Pressure: 0.000122 mmHg at 25 °C
3.Structure Descriptors of 5-Hydroxy-1-tetralone
SMILES:O=C2c1cccc(O)c1CCC2
Std. InChI:InChI=1S/C10H10O2/c11-9-5-1-3-7-8(9)4-2-6-10(7)12/h1,3,5,11H,2,4,6H2
Std. InChIKey:YPPZCRZRQHFRBH-UHFFFAOYSA-N
4.Safety profile of 5-Hydroxy-1-tetralone
Hazard Codes:.png){kind=small}
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-37/39-26-36
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
5.Toxicity of 5-Hydroxy-1-tetralone
RTECS#: CAS# 28315-93-7: None listed
LD50/LC50: RTECS: Not available.
Carcinogenicity: 5-Hydroxy-1-tetralone - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
Other: The toxicological properties have not been fully investigated.