CAS No.29094-61-9,Glipizide Suppliers

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Basic Information

Molecular Structure:
CAS No.:	29094-61-9
Name:	Glipizide
Article Data:	12

Formula:	C₂₁H₂₇N₅O₄S
Molecular Weight:	445.542
Synonyms:	Glucotrol;Glydiazinamide;Prestwick_242;N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-pyrazine-2-carboxamide;Pyrazinecarboxamide,N-[2-[4-[[[(cyclohexylamino) carbonyl]amino]sulfonyl]phenyl]- ethyl]-5-methyl-;TK 1320;Glucotrol (TN);(Glipizide);
EINECS:	249-427-6
Density:	1.34 g/cm³
Melting Point:	208-209 °C
Solubility:	methanol: 1.9 mg/mL
Appearance:	crystalline solid
Hazard Symbols:	Xi,Xn
Risk Codes:	21-36/38-46-62-63
Safety:	24/25-53-36/37-26-25
PSA:	138.53000
LogP:	4.33160

Synthetic route

: 201230-82-2
carbon monoxide

: C14H16N4O3S*NaCl

: 108-91-8
cyclohexylamine

: 29094-61-9
glipizide

Conditions

Conditions	Yield
With iron(III)-acetylacetonate In methanol at 20 - 30℃; for 6h;	85%

...Expand

: 2015-16-9
N-(4-[2-amino-ethyl]-benzenesulfonyl)-N'-cyclohexyl urea

: 41110-33-2
5-methylpyrazine-2-carboxylic acid methyl ester

: 29094-61-9
glipizide

Conditions

Conditions	Yield
With water; sodium methylate In methanol at 85℃; Concentration; Temperature; Solvent;	84%

ethyl cellulose: ethyl cellulose

: 88-12-0
1-ethenyl-2-pyrrolidinone

: 29094-61-9
glipizide

: 35303-76-5
4-(2-aminoethyl)benzenesulfonamide

: 29094-61-9
glipizide

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide / 4 h / 20 °C 2: potassium carbonate / acetone / 3 h / 50 - 55 °C 3: hydrogenchloride / methanol / 3 h / 50 - 55 °C 4: sodium methylate; water / methanol / 85 °C View Scheme

: 258262-54-3
tert-butyl (4-sulfamoyl phenethyl)carbamate

: 29094-61-9
glipizide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: potassium carbonate / acetone / 3 h / 50 - 55 °C 2: hydrogenchloride / methanol / 3 h / 50 - 55 °C 3: sodium methylate; water / methanol / 85 °C View Scheme

: tert-butyl (4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)carbamate

: 29094-61-9
glipizide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / methanol / 3 h / 50 - 55 °C 2: sodium methylate; water / methanol / 85 °C View Scheme

: 29094-61-9
glipizide

: 33288-71-0
N-[2-[4-(amino-sulfonyl)phenyl]ethyl]-5-methylpyrazinecarboxamide

Conditions

Conditions	Yield
With 3-azapentane-1,5-diamine at 120℃; for 6h; Sealed tube;	89%
With dmap; phthalic anhydride In pyridine for 5h; Reflux; Inert atmosphere;	63%
With pyridine; dmap; phthalic anhydride for 5h; Inert atmosphere; Reflux;	63%

: 108-24-7
acetic anhydride

: 29094-61-9
glipizide

: N-<4-<2-(5-Methyl-2-pyrazincarboxamido)ethyl>benzolsulfonyl>acetamid

Conditions

Conditions	Yield
With pyridine for 0.25h;	73%

: 23911-26-4
diethylenetriaminepentaacetic dianhydride

: 29094-61-9
glipizide

: 848488-95-9
DTPA-glipizide

Conditions

Conditions	Yield
Stage #1: glipizide With sodium amide In dimethyl sulfoxide at 20℃; for 0.166667h; Stage #2: diethylenetriaminepentaacetic dianhydride With sodium amide In dimethyl sulfoxide at 20℃; for 4.16667h;	61.7%

: 29094-61-9
glipizide

A: N-Cyclohexyl-N',N''-bis-<4-<2-(5-methyl-2-pyrazincarboxamido)ethyl>benzolsulfonyl>guanidin

B: 33288-71-0
N-[2-[4-(amino-sulfonyl)phenyl]ethyl]-5-methylpyrazinecarboxamide

Conditions

Conditions	Yield
With pyridine; p-toluenesulfonyl chloride Heating;	A 60% B 17%

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Chemistry

Molecular Structure of Glipizide (CAS NO.29094-61-9):

IUPAC Name:N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-5-methylpyrazine-2-carboxamide
Molecular Formula: C₂₁H₂₇N₅O₄S
Molecular Weight: 445.535180 g/mol
Appearance: white solid
Melting Point: 208-209°C
H bond acceptors: 9
H bond donors: 3
Freely Rotating Bonds: 6
Polar Surface Area: 112.16Å²
Index of Refraction: 1.615
Molar Refractivity: 115.92 cm³
Molar Volume: 331.8 cm³
Surface Tension: 66.8 dyne/cm
Density: 1.34 g/cm³
Solubility: methanol 1.9 mg/mL
Categories: Intermediates & Fine Chemicals; Pharmaceuticals; API's; Potassium channel

Safety Profile

Safety Information of Glipizide (CAS NO.29094-61-9):
Hazard Codes: Harmful Xn, Irritant Xi
Risk Statements: 21-36/38-46-62-63
21:Harmful in contact with skin
36/38:Irritating to eyes and skin
46:May cause heritable genetic damage
62:Possible risk of impaired fertility
63:Possible risk of harm to the unborn child
Safety Statements: 24/25-53-36/37-26-25
24/25:Avoid contact with skin and eyes
53:Avoid exposure - obtain special instruction before use
36/37:Wear suitable protective clothing and gloves
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
25:Avoid contact with eyes
WGK Germany: 3
RTECS: YS7640000
F: 10

Specification

Glipizide , with CAS number of 29094-61-9, can be called 2-pyrazinecarboxamide, N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-5-methyl- ; N-(2-{4-[(Cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-5-methyl-2-pyrazinecarboxamide ; Pyrazinecarboxamide, N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-5-methyl- . Glipizide (CAS NO.29094-61-9) is an oral medium-to-long acting anti-diabetic drug.