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298-46-4

Basic Information
CAS No.: 298-46-4
Name: Carbamazepine
Molecular Structure:
Molecular Structure of 298-46-4 (Carbamazepine)
Formula: C15H12N2O
Molecular Weight: 236.27 .
Synonyms: Geigy 32883;Carbamazepine BP;Carbamazepine Bromine Free;5-Carbamyl-5H-dibenzo(b,f)azepine;Amizepin;Tegretal;Carbamazepine (JP14/USP);G 32883;Lexin;Karbamazepin;G-32883;Neurotol;Finlepsin;5-Carbamoyldibenzo(b,f)azepine;Carbamazepen;Tegretol (TN);5-Carbamoyl-5H-dibenzo(b,f)azepine;Carbazepine;Stazepine;Biston;5H-Dibenz[b,f]azepine-5-carboxamide;
EINECS: 206-062-7
Density: 1.266 g/cm3
Melting Point: 189-192 °C
Boiling Point: 410.984 °C at 760 mmHg
Flash Point: 202.356 °C
Solubility: insoluble in water
Appearance: white solid
Hazard Symbols: HarmfulXn
Risk Codes: 42/43-22-20/21/22
Safety: 37-24-22-36/37/39-36
Transport Information:
PSA: 46.33000
LogP: 4.15250
Synthetic route
256-96-2

dibenzoazepine

917-61-3

sodium isocyanate

298-46-4

carbamazepin

Conditions
ConditionsYield
In water; acetic acid at 15 - 60℃; for 4h; Product distribution / selectivity;98.8%
In acetic acid at 18 - 60℃; for 5h; Product distribution / selectivity;95.9%
In ethanol; acetic acid at 60 - 80℃; for 1.5h; Product distribution / selectivity;93.7%
59690-97-0

10-Brom-5-carbamoyl-5H-dibenzazepin

298-46-4

carbamazepin

Conditions
ConditionsYield
With tetraethylammonium perchlorate In water; N,N-dimethyl-formamide cathode: Hg, working potential: -1.80 V, charge: 2.0-2.1 F/mol, 4-5 h;98%
With tetraethylammonium perchlorate In water; N,N-dimethyl-formamide Mechanism; cathode: Hg, working potential: -1.80 V, charge: 2.0-2.1 F, 4-5 h; other substituted azepines;98%
590-28-3

potassium cyanate

256-96-2

dibenzoazepine

298-46-4

carbamazepin

Conditions
ConditionsYield
In water; acetic acid at 20 - 80℃; for 2 - 5.5h; Product distribution / selectivity;93.2%
59690-99-2, 141701-26-0, 143667-56-5

trans-10,11-dibromo-10,11-dihydro-5H-dibenzazepine-5-carboxamide

298-46-4

carbamazepin

Conditions
ConditionsYield
With tetraethylammonium perchlorate In water; N,N-dimethyl-formamide cathode: Hg, working potential: -0.5 V, charge: 1.9-2.1 F/mol, 3-4 h;92%
28721-07-5

oxcarbazepine

298-46-4

carbamazepin

Conditions
ConditionsYield
With methanol; sodium tetrahydroborate at 45 - 50℃; for 3h;91.5%
1189-71-5

isocyanate de chlorosulfonyle

256-96-2

dibenzoazepine

298-46-4

carbamazepin

Conditions
ConditionsYield
In dichloromethane; water at 5 - 30℃;78%
143667-55-4

10,11-Dibrom-5-carbamoyl-5H-dibenzazepin

298-46-4

carbamazepin

Conditions
ConditionsYield
With tetraethylammonium perchlorate In N,N-dimethyl-formamide for 12h; cathode: Hg, working potential: -1.35 V, charge: 2.6-3.0 F/mol, initial current density: 0.5 A/dm2;17%
42787-75-7

5-cyanodibenzazepine

298-46-4

carbamazepin

Conditions
ConditionsYield
With hydrogenchloride at 100℃; for 1h; Yield given;
With sulfuric acid; acetic acid In ice-water
33948-22-0

5H-dibenz[b,f]azepine-5-carbonylchloride

298-46-4

carbamazepin

Conditions
ConditionsYield
With ammonia In ethanol for 3h; Heating;5 g
With ammonium hydroxide In methanol at 75 - 85℃; for 5h; Yield given;
Multi-step reaction with 3 steps
1: 78 percent / Br2 / chlorobenzene / 170 °C
2: 90 percent / conc. aq. NH3 / various solvent(s) / 2 h / 100 °C
3: 17 percent / (C2H5)4NClO4 / dimethylformamide / 12 h / cathode: Hg, working potential: -1.35 V, charge: 2.6-3.0 F/mol, initial current density: 0.5 A/dm2
View Scheme
52618-28-7, 94063-21-5

carbamazepine cyclobutyl dimer

298-46-4

carbamazepin

Conditions
ConditionsYield
In ethanol Quantum yield; Irradiation;

5H-dibenz(b,f)azepine hydrochloride

298-46-4

carbamazepin

Conditions
ConditionsYield
With urea In acetic acid
With urea In acetic acid

C20H21N3O3S

A

C5H11NO3S

B

298-46-4

carbamazepin

Conditions
ConditionsYield
With water at 25℃; Kinetics; Further Variations:; pH-values;

C17H17N3OS*C2HF3O2

298-46-4

carbamazepin

Conditions
ConditionsYield
With water at 70℃; pH=4; Kinetics; Further Variations:; pH-values; Temperatures;
494-19-9

9,10-dihydrodibenzazepine

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 90 percent / toluene / 3.5 h / 90 - 95 °C
2: Br2 / chlorobenzene / 1.5 h / 145 - 150 °C
3: chlorobenzene / 2 h / 150 - 155 °C
4: 25percent NH4OH / methanol / 5 h / 75 - 85 °C
View Scheme
Multi-step reaction with 3 steps
1: N-Bromosuccinimide
2: toluene
3: ammonia
View Scheme
33948-20-8

10-bromo-10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorobenzene / 2 h / 150 - 155 °C
2: 25percent NH4OH / methanol / 5 h / 75 - 85 °C
View Scheme
33948-19-5

10,11-dihydro-dibenzo[b,f]azepine-5-carbonyl chloride

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Br2 / chlorobenzene / 1.5 h / 145 - 150 °C
2: chlorobenzene / 2 h / 150 - 155 °C
3: 25percent NH4OH / methanol / 5 h / 75 - 85 °C
View Scheme
143667-53-2

10-Brom-5-chlorcarbonyl-5H-dibenzazepin

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 92 percent / (C2H5)4NClO4 / dimethylformamide; H2O / cathode: Hg, working potential: -1.60 V, charge: 2.0-2.1 F/mol, 4-5 h
2: 78 percent / Br2 / chlorobenzene / 170 °C
3: 90 percent / conc. aq. NH3 / various solvent(s) / 2 h / 100 °C
4: 17 percent / (C2H5)4NClO4 / dimethylformamide / 12 h / cathode: Hg, working potential: -1.35 V, charge: 2.6-3.0 F/mol, initial current density: 0.5 A/dm2
View Scheme
143667-54-3

10,11-Dibrom-5-chlorcarbonyl-5H-dibenzazepin

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 90 percent / conc. aq. NH3 / various solvent(s) / 2 h / 100 °C
2: 17 percent / (C2H5)4NClO4 / dimethylformamide / 12 h / cathode: Hg, working potential: -1.35 V, charge: 2.6-3.0 F/mol, initial current density: 0.5 A/dm2
View Scheme
256-96-2

dibenzoazepine

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: CHCl3 / 0.5 h / cooling
2: 10 percent HCl / 1 h / 100 °C
View Scheme
Multi-step reaction with 2 steps
1: toluene / 0.5 h
2: 5 g / NH3 (gas) / ethanol / 3 h / Heating
View Scheme
With trichloroacetic acid In water; toluene
32621-46-8

diphenylamine-2,2'-dicarbonyl chloride

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: H2 / Palladium-Barium sulphate; Quinolin sulphate / xylene / 2.5 h / Heating
2: 3.8 g / Hydrazine hydrate / acetic acid / 2 h / Heating
3: toluene / 0.5 h
4: 5 g / NH3 (gas) / ethanol / 3 h / Heating
View Scheme
49579-63-7

diphenylamine-2,2′-dicarboxaldehyde

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 3.8 g / Hydrazine hydrate / acetic acid / 2 h / Heating
2: toluene / 0.5 h
3: 5 g / NH3 (gas) / ethanol / 3 h / Heating
View Scheme
579-92-0

Vanadox

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: 11.8 g / Thionyl chloride; Pyridine / 5 h / Heating
2: H2 / Palladium-Barium sulphate; Quinolin sulphate / xylene / 2.5 h / Heating
3: 3.8 g / Hydrazine hydrate / acetic acid / 2 h / Heating
4: toluene / 0.5 h
5: 5 g / NH3 (gas) / ethanol / 3 h / Heating
View Scheme
42787-75-7

5-cyanodibenzazepine

7722-84-1

dihydrogen peroxide

298-46-4

carbamazepin

Conditions
ConditionsYield
With sodium bicarbonate In methanol; water
256-96-2

dibenzoazepine

monomeric cyanic acid

monomeric cyanic acid

298-46-4

carbamazepin

Conditions
ConditionsYield
With sulfuric acid In nitrogen; ethyl acetate
With acetic acid In nitrogen
In nitrogen; water; acetic acid

5H-dibenz(b,f)azepine hydrochloride

256-96-2

dibenzoazepine

monomeric cyanic acid

monomeric cyanic acid

298-46-4

carbamazepin

Conditions
ConditionsYield
In nitrogen; toluene
In 5,5-dimethyl-1,3-cyclohexadiene; nitrogen
256-96-2

dibenzoazepine

420-05-3

cyanic acid

298-46-4

carbamazepin

Conditions
ConditionsYield
With hydrogenchloride In nitrogen; ethyl acetate
256-96-2

dibenzoazepine

506-89-8

urea hydrochloride

298-46-4

carbamazepin

Conditions
ConditionsYield
In acetic acid
In acetic acid

C25H18N4O7

298-46-4

carbamazepin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 6 h / 0 °C / Inert atmosphere
2.1: methylhydrazine / tetrahydrofuran / -80 °C / Inert atmosphere
2.2: 24 h / 20 °C
3.1: 25 °C / pH 5 / aq. buffer
View Scheme

C25H18N4O7

A

298-46-4

carbamazepin

B

C17H15N3O2

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: dicyclohexyl-carbodiimide / tetrahydrofuran; dichloromethane / 6 h / 0 °C / Inert atmosphere
2.1: methylhydrazine / tetrahydrofuran / -80 °C / Inert atmosphere
2.2: 24 h / 20 °C
3.1: 25 °C / pH 10 / aq. buffer
View Scheme
298-46-4

carbamazepin

42787-75-7

5-cyanodibenzazepine

Conditions
ConditionsYield
With bis(trichloromethyl) carbonate In toluene for 5h; Product distribution / selectivity; Reflux;96%
With sodium hydroxide; Aliquat In chloroform at 20℃; for 70h;62%
With oxalyl dichloride; dimethyl sulfoxide; triethylamine In dichloromethane at -78 - 20℃;4%
With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride In dichloromethane; chloroform; water at 45 - 50℃; for 5 - 6h;
298-46-4

carbamazepin

36507-30-9

carbamazepine 10,11-epoxide

Conditions
ConditionsYield
With peracetic acid; potassium permanganate supported on alumina; sodium carbonate In dichloromethane; acetic acid at 20℃; for 1.66667h; Heating / reflux;91%
With peroxyacetic acid; potassium permanganate on alumina; sodium carbonate; acetic acid In dichloromethane for 1.66667h; Reflux;91%
With perpropionic acid; sodium carbonate; acetic acid In dichloromethane at 20℃; for 2h; Reflux;91%
298-46-4

carbamazepin

59690-99-2, 141701-26-0, 143667-56-5

trans-10,11-dibromo-10,11-dihydro-5H-dibenzazepine-5-carboxamide

Conditions
ConditionsYield
With bromine In 1,2-dichloro-ethane for 2h; Ambient temperature;90%
With bromine In 1,2-dichloro-ethane at 25℃; Rate constant; Mechanism;100 % Chromat.
298-46-4

carbamazepin

copper(II) choride dihydrate

[Cu(carbamazepine)2(H2O)2]Cl2*4H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;88.1%
298-46-4

carbamazepin

3564-73-6

10,11-Dihydrocarbamazepin

Conditions
ConditionsYield
With tetraethylammonium perchlorate; ammonium chloride In water; N,N-dimethyl-formamide cathodic (Hg, -2.0 V vs. SCE) reduction;85%
With tetraethylammonium perchlorate; ammonium chloride In water; N,N-dimethyl-formamide Mechanism; cathodic (Hg, -2.0 V vs. SCE) reduction;85%
With electrochemical reduction Mechanism; var. pH;
298-46-4

carbamazepin

256-96-2

dibenzoazepine

Conditions
ConditionsYield
With tetraethoxy tellurium(IV) In tetrachloromethane for 3h; Heating;85%
With hydrogenchloride In water for 12h; Reagent/catalyst; Darkness;
With carbon dioxide at 160 - 200℃;
298-46-4

carbamazepin

nickel(II) chloride dihydrate

[Ni(carbamazepine)2(H2O)2]Cl2*5H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;85%
298-46-4

carbamazepin

cobalt(II) chloride hexahydrate

[Co(carbamazepine)2(H2O)2]Cl2*9H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;84.15%
298-46-4

carbamazepin

139489-10-4

Carbamazepin*Formamid

Conditions
ConditionsYield
In chloroform81.5%
In tetrahydrofuran
In methanol

iron(III) chloride

298-46-4

carbamazepin

[Fe(carbamazepine)2(H2O)2]Cl3*5H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;80.2%
13520-92-8

ziconium(IV) oxychloride octahydrate

298-46-4

carbamazepin

[ZrO(carbamazepine)2(H2O)]Cl2*8H2O

Conditions
ConditionsYield
In ethanol for 3h; Reflux;79.8%
298-46-4

carbamazepin

109745-70-2, 19757-97-2

methyl glyoxylate methyl hemi-acetal

187866-36-0

[(Dibenzo[b,f]azepine-5-carbonyl)-amino]-hydroxy-acetic acid methyl ester

Conditions
ConditionsYield
In chloroform for 2h; Heating;78%
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Chemistry

IUPAC Name: Benzo[b][1]benzazepine-11-carboxamide
Molecular Formula: C15H12N2O
Molar mass: 236.27 g/mol
EINECS: 206-062-7
Density: 1.266 g/cm3
Flash Point: 202.4 °C
Index of Refraction: 1.669
Boiling Point: 411 °C at 760 mmHg
Vapour Pressure: 5.78E-07 mmHg at 25 °C
Melting point: 189-192 °C
Storage temp: 2-8 °C
Appearance: White Solid
Solubility: Soluble in Ethanol , Acetone , Propylene glycol , insoluble in water. Odorless, tasteless
Product categories: Acids and Derivatives;Active Pharmaceutical Ingredients;APIs;Intermediates & Fine Chemicals;Heterocycles
Structure of Carbamazepine (CAS NO.298-46-4):
                        
XLogP3-AA: 2.5
H-Bond Donor: 1
H-Bond Acceptor: 1
Canonical SMILES: C1=CC=C2C(=C1)C=CC3=CC=CC=C3N2C(=O)N
InChI: InChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)
17/h1-10H,(H2,16,18) 

History

 Carbamazepine (CAS NO.298-46-4) was discovered by chemist Walter Schindler at J.R. Geigy AG (now part of Novartis) in Basel, Switzerland, in 1953, and was first marketed as a drug to treat trigeminal neuralgia (formerly known as tic douloureux) in 1962. It has been approved in the U.S. since 1974. Carbamazepine would be studied for bipolar disorder throughout the 1970s.

Uses

 Carbamazepine (CAS NO.298-46-4) is an anticonvulsant and mood stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder, as well as trigeminal neuralgia. It is also used off-label for a variety of indications, including schizophrenia, attention-deficit hyperactivity disorder (ADHD), paroxysmal extreme pain disorder, phantom limb syndrome, and post-traumatic stress disorder.

Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
child TDLo oral 19mg/kg/4W-I (19mg/kg) PERIPHERAL NERVE AND SENSATION: FASCICULATIONS Pediatrics. Vol. 73, Pg. 841, 1984.
child TDLo oral 25926ug/kg (25.926mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 35, Pg. 320, 1993.
child TDLo oral 55mg/kg (55mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: COMA
Journal of Toxicology, Clinical Toxicology. Vol. 38, Pg. 323, 2000.
child TDLo oral 65mg/kg (65mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: COMA
LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of Pediatrics. Vol. 121, Pg. 295, 1992.
child TDLo oral 420mg/kg/3W-I (420mg/kg) SENSE ORGANS AND SPECIAL SENSES: OTHER: EYE
BEHAVIORAL: TREMOR
BEHAVIORAL: GENERAL ANESTHETIC
Journal of Toxicology, Clinical Toxicology. Vol. 36, Pg. 109, 1998.
child TDLo oral 1050mg/kg/6W- (1050mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) American Journal of Psychiatry. Vol. 143, Pg. 1176, 1985.
dog LD50 oral 5620mg/kg (5620mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.
guinea pig LD50 oral 920mg/kg (920mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.
human TDLo oral 43mg/kg (43mg/kg) BEHAVIORAL: SLEEP
BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"
GASTROINTESTINAL: NAUSEA OR VOMITING
British Medical Journal. Vol. 1, Pg. 754, 1977.
man LDLo oral 54mg/kg/9D-I (54mg/kg) BEHAVIORAL: ATAXIA

KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED
BLOOD: AGRANULOCYTOSIS
Canadian Medical Association Journal. Vol. 132, Pg. 1040, 1985.
man TDLo oral 94mg/kg/11D-I (94mg/kg) BLOOD: THROMBOCYTOPENIA Journal of Clinical Pyschopharmacology. Vol. 10, Pg. 305, 1990.
man TDLo oral 160mg/kg/3W-I (160mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Journal of Clinical Pyschopharmacology. Vol. 5, Pg. 185, 1985.
man TDLo oral 253mg/kg/6W-I (253mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING
LIVER: LIVER FUNCTION TESTS IMPAIRED
Journal of Clinical Pyschopharmacology. Vol. 6, Pg. 251, 1986.
mouse LD50 intraperitoneal 114mg/kg (114mg/kg)   Farmakologiya i Toksikologiya Vol. 53(4), Pg. 19, 1990.
mouse LD50 oral 529mg/kg (529mg/kg)   Farmaco. Vol. 44, Pg. 595, 1989.
mouse LD50 subcutaneous > 1gm/kg (1000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 477, 1980.
rabbit LD50 oral 2680mg/kg (2680mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 63, 1972.
rat LD50 intraperitoneal 158mg/kg (158mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 202, Pg. 106, 1973.
rat LD50 oral 1957mg/kg (1957mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) Japanese Kokai Tokyo Koho Patents. Vol. #79-163823,
rat LD50 subcutaneous > 1500mg/kg (1500mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 30, Pg. 477, 1980.
women LDLo oral 1920mg/kg/17W (1920mg/kg) BLOOD: APLASTIC ANEMIA American Journal of Psychiatry. Vol. 142, Pg. 974, 1985.
women TDLo oral 28mg/kg/4D-I (28mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
GASTROINTESTINAL: NAUSEA OR VOMITING
American Journal of Psychiatry. Vol. 143, Pg. 1328, 1986.
women TDLo oral 112mg/kg/2W-I (112mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING
BLOOD: THROMBOCYTOPENIA
American Journal of Psychiatry. Vol. 150, Pg. 1750, 1993.
women TDLo oral 144mg/kg/2W-I (144mg/kg) BLOOD: THROMBOCYTOPENIA
SKIN AND APPENDAGES (SKIN): "DERMATITIS, ALLERGIC: AFTER SYSTEMIC EXPOSURE"
Journal of Clinical Psychiatry. Vol. 53, Pg. 378, 1992.
women TDLo oral 560mg/kg/4W-I (560mg/kg) BLOOD: CHANGES IN BONE MARROW NOT INCLUDED ABOVE British Journal of Clinical Practice. Vol. 43, Pg. 302, 1989.
women TDLo oral 7604mg/kg/69W (7604mg/kg) BEHAVIORAL: GENERAL ANESTHETIC

CARDIAC: EKG CHANGES NOT DIAGNOSTIC OF ABOVE
Japanese Heart Journal. Vol. 39, Pg. 469, 1998.
 

Safety Profile

Hazard Codes: HarmfulXn
Risk Statements: 42/43-22-20/21/22
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R22:Harmful if swallowed. 
R42/43:May cause sensitization by inhalation and skin contact.
Safety Statements: 37-24-22-36/37/39-36
S22:Do not breathe dust. 
S24:Avoid contact with skin. 
S36:Wear suitable protective clothing. 
S37:Wear suitable gloves. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 

Specification

 Carbamazepine ,its cas register number is 298-46-4. It can be called Finlepsin and Tegretol . And it has been sold under the names Biston, Tegretol, Calepsin, Equetro, Finlepsin, Sirtal, Carbatrol, Epitol, Stazepine, Telesmin, Teril, Trimonil, Timonil, Epimaz, Amizepin (Poland), Hermolepsin (Sweden), Carbama/Carbamaze (New Zealand), and Degranol (South Africa).