Products Categories
| CAS No.: | 3105-97-3 |
|---|---|
| Name: | 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE |
| Molecular Structure: | |
|
|
|
| Formula: | C20H24 N2 O2 S |
| Molecular Weight: | 356.489 |
| Synonyms: | Thioxanthen-9-one,1-[[2-(diethylamino)ethyl]amino]-4-(hydroxymethyl)- (7CI,8CI); 1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)-9H-thioxanthen-9-one;1-[[2-(Diethylamino)ethyl]amino]-4-(hydroxymethyl)thioxanthen-9-one; Hycanthon;Hycanthone; NCI 142982; NSC 134434; NSC 142982; Win 24933 |
| Density: | 1.25g/cm3 |
| Melting Point: | 100.6-102.8° |
| Boiling Point: | 570.5°Cat760mmHg |
| Flash Point: | 298.9°C |
| Hazard Symbols: |
|
| Risk Codes: | 45-46-20/21/22 |
| Safety: | Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Experimental teratogenic effects. Human mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx. |
| PSA: | 80.81000 |
| LogP: | 3.73370 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
- 361456-36-2METHYL (R)-(+)-ISOCYANATO-3-PHENYLPROPI&
- 5156-58-1N-(1-Benzyl-4-pipperidinyl)-N-phenylpropanamide HCl
- 81281-59-67-Benzylideneaminotheophylline
- 50288-62-5threo-Phenyl-2-piperidyl acetamide
- 82993-81-5D-threo-Ritalinic acid hydrochloride
- 47087-37-6Z-D-Glu-OMe
- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
| Conditions | Yield |
|---|---|
| In dichloromethane | 100% |
- 3105-97-3
hycanthone
- 108-24-7
acetic anhydride
- 3612-72-4
4-acetoxymethyl-1-(2-diethylamino-ethylamino)-thioxanthen-9-one
| Conditions | Yield |
|---|---|
| With pyridine | 63% |
| Conditions | Yield |
|---|---|
| With sulfuric acid In acetic acid at 140℃; for 0.166667h; | 43% |
- 3105-97-3
hycanthone
- 77287-34-4, 77287-35-5, 60100-09-6
formamide
- 146537-03-3
N-[[1-[[2-(diethylamino)ethyl]amino]-9-oxothioxanthen-4-yl]methyl]formamide
| Conditions | Yield |
|---|---|
| With sulfuric acid In acetic acid at 140℃; for 0.166667h; | 43% |
| Conditions | Yield |
|---|---|
| With pyridine In dichloromethane | 19% |
| Conditions | Yield |
|---|---|
| In dichloromethane |
| Conditions | Yield |
|---|---|
| In dichloromethane |
| Conditions | Yield |
|---|---|
| With pyridine for 1.5h; Ambient temperature; |
- 3105-97-3
hycanthone
| Conditions | Yield |
|---|---|
| Stage #1: hycanthone; HO-(2,6-naphthylidene)-C(NH)NHC(O)OCH2-(p-C6H4)-OCH2C(O)NHCH2-(polystyrene resin) With tributylphosphine; diamide; triethylamine In tetrahydrofuran; dichloromethane for 15h; Solid phase reaction; Stage #2: With trifluoroacetic acid In dichloromethane; water for 4h; Solid phase reaction; |
- 3105-97-3
hycanthone
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: pyridine / 1.5 h / Ambient temperature 2: 80 percent / tetra-n-butylammonium bromide / dimethylformamide / 2 h / 100 °C View Scheme |
What can I do for you?
Get Best Price
Chemistry
The IUPAC name of Hycanthone (CAS NO.3105-97-3):
1-(2-Diethylaminoethylamino)-4-(hydroxymethyl)thioxanthen-9-one
Synonyms: 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)-9H-thioxanthen-9-one ; 1-((2-(Diethylamino)ethyl)amino)-4-(hydroxymethyl)thioxanthen-9-one ; 5-18-12-00070 (Beilstein Handbook Reference) ; 9H-Thioxanthen-9-one, 1-((2-(diethylamino)ethyl)amino)-4-(hydroxymethyl)- ; BRN 1402722 ; CCRIS 957 ; Hicantona ; Hicantona [INN-Spanish] ; Hycanthon ; Hycanthone ; Hycanthonum ; Hycanthonum [INN-Latin] ; Lucanthone metabolite ; NSC 134434 ; NSC 142982 ; WIN 24933
CAS: 3105-97-3
EINECS: 221-463-7
Molecular Formula: C20H24N2O2S
Formula Weight: 356.48 g/mol
Molecular Structure:
.png)
Index of Refraction: 1.658
Density: 1.25 g/cm3
Flash Point: 298.9 °C
Boiling Point: 570.5 °C at 760 mmHg
General Description: Odorless canary yellow to yellow-orange crystalline powder. Bitter taste.
Air & Water Reactions: 1-[(2-[DIETHYLAMINO]ETHYL)AMINO]-4-[HYDROXYMETHYL]-9H-THIOXANTHEN-9-ONE may be sensitive to prolonged exposure to air and light. Highly soluble in water.
Toxicity Data With Reference
The toxicity of Hycanthone (CAS NO.3105-97-3):
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 253mg/kg (253mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 200, Pg. 1, 1977. | |
| mouse | LD50 | intravenous | 70mg/kg (70mg/kg) | Egyptian Journal of Bilharziasis. Vol. 1, Pg. 181, 1974. | |
| mouse | LD50 | oral | 1120mg/kg (1120mg/kg) | Egyptian Journal of Bilharziasis. Vol. 1, Pg. 181, 1974. | |
| mouse | LD50 | subcutaneous | 270mg/kg (270mg/kg) | Egyptian Journal of Bilharziasis. Vol. 1, Pg. 181, 1974. | |
| rat | LD50 | intravenous | 75mg/kg (75mg/kg) | Egyptian Journal of Bilharziasis. Vol. 1, Pg. 181, 1974. | |
| rat | LD50 | oral | 980mg/kg (980mg/kg) | Egyptian Journal of Bilharziasis. Vol. 1, Pg. 181, 1974. | |
| rat | LD50 | subcutaneous | 286mg/kg (286mg/kg) | Egyptian Journal of Bilharziasis. Vol. 1, Pg. 181, 1974. |
Consensus Reports
EPA Genetic Toxicology Program.
Safety Profile
The Hazard Codes of Hycanthone (CAS NO.3105-97-3): 
T
Risk Statements: R45:May cause cancer. R46:May cause heritable genetic damage. R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: S53:Avoid exposure - obtain special instructions before use. S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
WGK Germany: 3
RTECS: XO1590000
Poison by subcutaneous, intravenous, and intramuscular routes. Moderately toxic by ingestion. Experimental teratogenic effects. Human mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of NOx and SOx.