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| CAS No.: | 329-56-6 |
|---|---|
| Name: | L-NORADRENALINE HYDROCHLORIDE |
| Molecular Structure: | |
|
|
|
| Formula: | C8H11 N O3 . Cl H |
| Molecular Weight: | 205.641 |
| Synonyms: | 1,2-Benzenediol,4-(2-amino-1-hydroxyethyl)-, hydrochloride, (R)-; 1,2-Benzenediol,4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (9CI); Benzyl alcohol, a-(aminomethyl)-3,4-dihydroxy-,hydrochloride, (-)- (8CI); (-)-Noradrenaline hydrochloride; (-)-Norepinephrinehydrochloride; Arterenol hydrochloride; Aterenol; Noradrenaline hydrochloride;Norepinephrine hydrochloride; R-(-)-Noradrenaline hydrochloride;R-(-)-Norepinephrine monohydrochloride; l-Arterenol hydrochloride;l-Noradrenaline hydrochloride; l-Norepinephrine hydrochloride |
| Density: | 1.397g/cm3 |
| Melting Point: |
~150 °C (dec.) |
| Boiling Point: | 442.6°Cat760mmHg |
| Flash Point: | 221.5°C |
| Hazard Symbols: |
|
| Risk Codes: | 25 |
| Safety: | Poison by ingestion, subcutaneous, and intraduodenal routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also l-NOREPINEPHRINE. |
| PSA: | 86.71000 |
| LogP: | 1.59220 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
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| Conditions | Yield |
|---|---|
| In d(4)-methanol; water-d2 Equilibrium constant; |
- 1031721-23-9
N-{{7-[bis(carboxymethyl)amino]coumarin-4-yl}methyloxycarbonyl}-L-norepinephrine
A
- 876275-37-5
7-[bis(carboxymethyl)amino]-4-(hydroxymethyl)coumarin
B
- 124-38-9
carbon dioxide
C
- 329-56-6
norepinephrine hydrochloride
| Conditions | Yield |
|---|---|
| With potassium hydroxide; HEPES buffer In acetonitrile pH=7.2; Quantum yield; UV-irradiation; |
- 329-56-6
norepinephrine hydrochloride
- 79539-35-8
4-amino-3,6-disulfo-1,8-naphthaldehyde anhydride dipotassium salt
| Conditions | Yield |
|---|---|
| In water Heating; pH 5, Li(1+)/H(1+) acetate buffer; |
- 52-90-4
L-Cysteine
- 329-56-6
norepinephrine hydrochloride
A
- 175482-45-8
7-(1-Hydroxy-2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| With phosphate buffer for 0.5h; electro-oxidation reaction; Further byproducts given; |
- 52-90-4
L-Cysteine
- 329-56-6
norepinephrine hydrochloride
A
- 175482-45-8
7-(1-Hydroxy-2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| With phosphate buffer for 0.5h; electro-oxidation reaction; Further byproducts given; |
- 52-90-4
L-Cysteine
- 329-56-6
norepinephrine hydrochloride
A
- 175482-45-8
7-(1-Hydroxy-2-aminoethyl)-3,4-dihydro-5-hydroxy-2H-1,4-benzothiazine-3-carboxylic acid
| Conditions | Yield |
|---|---|
| With phosphate buffer for 0.5h; electro-oxidation reaction; Further byproducts given; |
- 329-56-6
norepinephrine hydrochloride
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 0.5h; electrochemical oxidation; |
- 52-90-4
L-Cysteine
- 329-56-6
norepinephrine hydrochloride
C
- 196309-90-7
(R)-7-[(R)-2-((R)-2-Amino-2-carboxy-ethyldisulfanyl)-1-carboxy-ethylamino]-10-((R)-2-amino-2-carboxy-ethylsulfanyl)-9-hydroxy-1,2,3,6-tetrahydro-4,5-dithia-1,8-diaza-phenanthrene-2-carboxylic acid
| Conditions | Yield |
|---|---|
| pH 7.4; |
| Conditions | Yield |
|---|---|
| In d(4)-methanol; water-d2 Equilibrium constant; Thermodynamic data; |
- 329-56-6
norepinephrine hydrochloride
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 0.1M aq. HCl / 0.5 h / electrochemical oxidation 2: 0.1N HCl View Scheme |
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Chemistry
IUPAC Name: [2-(3,4-Dihydroxyphenyl)-2-hydroxyethyl]azanium chloride
Synonyms: 1,2-Benzenediol, 4-[(1R)-2-amino-1-hydroxyethyl]-, hydrochloride (1:1) ; 4-[(1R)-2-Amino-1-hydroxyethyl]benzene-1,2-diol hydrochloride (1:1) ; Aktamin hydrochloride ; Levophed hydrochloride
CAS NO:329-56-6
Molecular Formula of Norepinephrine hydrochloride (CAS NO.329-56-6) :C8H12ClNO3
Molecular Weight of Norepinephrine hydrochloride (CAS NO.329-56-6) :205.64
Molecular Structure of Norepinephrine hydrochloride (CAS NO.329-56-6) :
EINECS: 222-395-0 
Flash Point: 221.5 °C
Enthalpy of Vaporization: 73.79 kJ/mol
Boiling Point: 442.6 °C at 760 mmHg
Vapour Pressure: 1.3E-08 mmHg at 25°C
Melting point: ~150 °C (dec.)
Storage temp: 2-8°C
Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 5mg/kg (5mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 99, Pg. 45, 1950. | |
| rat | LD50 | intraduodenal | 26mg/kg (26mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
| rat | LD50 | oral | 132mg/kg (132mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. | |
| rat | LD50 | subcutaneous | 29mg/kg (29mg/kg) | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 180, Pg. 155, 1969. |
Safety Profile
Poison by ingestion, subcutaneous, and intraduodenal routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also l-NOREPINEPHRINE.
Hazard Codes 
T,
C,
F
Risk Statements 25-34-11
R11:Highly flammable.
R25 :Toxic if swallowed.
R34:Causes burns.
Safety Statements 45-36/37/39-26-16
S16:Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS DN6475000
F 3-8-10-23
HazardClass 6.1(b)
PackingGroup III