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339549-67-6

Basic Information
CAS No.: 339549-67-6
Name: Cyclopentyl 3-methoxyphenyl ketone
Article Data: 4
Molecular Structure:
Molecular Structure of 339549-67-6 (Cyclopentyl 3-methoxyphenyl ketone)
Formula: C13H16O2
Molecular Weight: 204.269
Synonyms: CYCLOPENTYL 3-METHOXYPHENYL KETONE;Cyclopentyl(3-methoxyphenyl)methanone
Density: 1.076
Boiling Point: 311.7°C at 760 mmHg
Flash Point: 133.4°C
PSA: 26.30000
LogP: 3.06810
Synthetic route
1527-89-5

3-methoxybenzonitrile

33240-34-5

cyclopentylmagnesium bromide

339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

Conditions
ConditionsYield
In diethyl ether at 0 - 20℃; for 6h; Inert atmosphere;51%
Stage #1: 3-methoxybenzonitrile; cyclopentylmagnesium bromide In diethyl ether at 0℃; Inert atmosphere; Reflux;
Stage #2: With water In diethyl ether Acidic conditions;

C14H19BrO5S

339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

Conditions
ConditionsYield
With samarium diiodide In tetrahydrofuran at 23℃; Inert atmosphere;36%
137-43-9

Cyclopentyl bromide

1527-89-5

3-methoxybenzonitrile

339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

Conditions
ConditionsYield
With magnesium In tetrahydrofuran

C13H17BrO3

339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: trimethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
2: samarium diiodide / tetrahydrofuran / 23 °C / Inert atmosphere
View Scheme
502-44-3

hexahydro-2H-oxepin-2-one

339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere
1.2: -15 - 20 °C / Inert atmosphere
2.1: phenyltrimethylammonium tribromide / tetrahydrofuran / 23 °C / Inert atmosphere
3.1: trimethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
4.1: samarium diiodide / tetrahydrofuran / 23 °C / Inert atmosphere
View Scheme

C13H18O3

339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: phenyltrimethylammonium tribromide / tetrahydrofuran / 23 °C / Inert atmosphere
2: trimethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
3: samarium diiodide / tetrahydrofuran / 23 °C / Inert atmosphere
View Scheme
2398-37-0

3-methoxyphenyl bromide

339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: magnesium; iodine / tetrahydrofuran / 2 h / 70 °C / Inert atmosphere
1.2: -15 - 20 °C / Inert atmosphere
2.1: phenyltrimethylammonium tribromide / tetrahydrofuran / 23 °C / Inert atmosphere
3.1: trimethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere
4.1: samarium diiodide / tetrahydrofuran / 23 °C / Inert atmosphere
View Scheme
339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

(-)-cyclopentyl(3-methoxyphenyl)methanol

Conditions
ConditionsYield
With phenylsilane; copper(II) acetate monohydrate; (S)-2,2',6,6'-tetramethoxy-4,4'-bis(di(3,5-xylyl)phosphino)-3,3'-bipyridine In toluene at -20℃; for 36h; enantioselective reaction;96%
339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

4009-98-7

(methoxymethyl)triphenylphosphonium chloride

C15H20O2

Conditions
ConditionsYield
Stage #1: (methoxymethyl)triphenylphosphonium chloride With n-butyllithium; phenyllithium In diethyl ether; hexane at -78 - 0℃;
Stage #2: (m-methoxyphenyl)cyclopentyl ketone In diethyl ether; hexane at -78 - 0℃; Wittig reaction;
339549-67-6

(m-methoxyphenyl)cyclopentyl ketone

1-bromocyclopentyl (m-methoxyphenyl) ketone

Conditions
ConditionsYield
With bromine In tetrachloromethane at 0 - 20℃; for 1h;30.1 g
With bromine In tetrachloromethane
With copper(ll) bromide In ethyl acetate for 4h; Reflux;274.6 g
With copper(ll) bromide In ethyl acetate for 4h; Reflux;
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