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| CAS No.: | 34381-71-0 |
|---|---|
| Name: | N-Methyl-L-prolinol |
| Molecular Structure: | |
|
|
|
| Formula: | C6H13NO |
| Molecular Weight: | 115.175 |
| Synonyms: | 2-Pyrrolidinemethanol,1-methyl-, (S)-;(-)-(S)-1-Methyl-2-pyrrolidinemethanol;(2S)-(Hydroxymethyl)-1-methylpyrrolidine;(2S)-1-Methylpyrrolidin-2-ylmethanol;(2S)-1-Methylpyrrolidine-2-methanol;(S)-(-)-(1-Methyl-2-pyrrolidinyl)methanol;(S)-(-)-1-Methylpyrrolidine-2-methanol;(S)-(-)-2-Hydroxymethyl-1-methylpyrrolidine;(S)-1-Methyl-2-pyrrolidinemethanol;(S)-1-Methylpyrrolidin-2-ylmethanol;(S)-2-(Hydroxymethyl)-1-methylpyrrolidine;(S)-N-Methylpyrrolidine-2-methanol;L-(-)-N-Methyl-2-pyrrolidinylmethanol;L-N-Methylprolinol;2-Pyrrolidinemethanol,1-methyl-, (2S)-; |
| EINECS: | 251-981-9 |
| Density: | 0.973 g/cm3 |
| Boiling Point: | 164.8 °C at 760 mmHg |
| Flash Point: | 63.3 °C |
| Appearance: | white to light yellow crystal powder |
| Hazard Symbols: |
 Xi
|
| Risk Codes: | 36/37/38 |
| Safety: | 23-24/25-36-26 |
| PSA: | 23.47000 |
| LogP: | 0.01080 |
- 483366-12-7(2S,4R)-1-Boc-2-cyano-4-hydroxypyrrolidine
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- 73441-42-6METHYL-5-CHLORO-2,2-DIMETHYLVALERATE
- 68439-39-4Poly(oxy-1,2-ethanediyl), alpha-(2-ethylhexyl)-omega-hydroxy-,
- 852475-26-4MC1568
- 59936-29-7
(S)-N-(tert-butoxycarbonyl)proline methyl ester
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In diethyl ether | 90% |
- 50-00-0
formaldehyd
- 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| With formic acid In water for 20h; Heating; | 65% |
| With formic acid; water anschliessenden Erhitzen; | |
| With hydrogen; platinum(IV) oxide In water for 24h; | 2.4 g |
| With formic acid | |
| With formic acid Yield given; |
- 475-11-6, 58123-62-9, 68078-09-1
N-methyl-L-proline
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran for 4h; Heating; | 65% |
- 147-85-3
L-proline
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| With aq. sodium hydroxide; acetic anhydride In tetrahydrofuran; formic acid; water | 57% |
| Multi-step reaction with 2 steps 1: NaBH4, H2SO4 2: HCOOH View Scheme | |
| Multi-step reaction with 2 steps 1: NaBH4, conc. H2SO4 2: HCOOH View Scheme | |
| Multi-step reaction with 2 steps 1: acetic anhydride / 2 h / Ambient temperature 2: LiAlH4 / tetrahydrofuran / 48 h / Heating View Scheme | |
| Multi-step reaction with 3 steps 1: 94 percent / H2O 2: 95 percent / diethyl ether 3: 90 percent / 3 eq. LiAlH4 / diethyl ether View Scheme |
- 27957-91-1
N-Methyl-L-proline Methyl Ester
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| 53% | |
| With lithium aluminium tetrahydride In tetrahydrofuran |
- 1148-11-4
N-Benzyloxycarbonyl-L-proline
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran 1.) room temp., 1 h, 2.) reflux, 3 h; | 49% |
| Conditions | Yield |
|---|---|
| Stage #1: formic acid; L-proline With acetic anhydride Stage #2: With lithium aluminium tetrahydride | 48% |
- 13200-83-4
(2S)-1-formylpyrrolidine-2-carboxylic acid
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran for 48h; Heating; Yield given; |
- 5211-23-4
N-carbobenzyloxy-L-proline methyl ester
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride |
- 68078-09-1
N-methylproline
A
- 3554-65-2, 30727-24-3, 34381-71-0, 99494-01-6
(R)-N-methylpyrrolidine-2-methanol
B
- 34381-71-0
(S)-2-hydroxymethyl-1-methylpyrrolidine
| Conditions | Yield |
|---|---|
| With lithium aluminium tetrahydride In tetrahydrofuran Heating; Title compound not separated from byproducts; |
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Chemistry
Molecule structure of N-Methyl-L-prolinol (CAS NO.34381-71-0):
IUPAC Name: (1-Methylpyrrolidin-2-yl)methanol
Molecular Weight: 115.17352 g/mol
Molecular Formula: C6H13NO
Density: 0.973 g/cm3
Boiling Point: 164.8 °C at 760 mmHg
Flash Point: 63.3 °C
Index of Refraction: 1.468
Molar Refractivity: 32.95 cm3
Molar Volume: 118.3 cm3
Surface Tension: 32.2 dyne/cm
Enthalpy of Vaporization: 46.74 kJ/mol
Vapour Pressure: 0.649 mmHg at 25 °C
Storage Temp.: −20 °C
XLogP3-AA: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 2
Rotatable Bond Count: 1
Exact Mass: 115.099714
MonoIsotopic Mass: 115.099714
Topological Polar Surface Area: 23.5
Heavy Atom Count: 8
Canonical SMILES: CN1CCCC1CO
InChI: InChI=1S/C6H13NO/c1-7-4-2-3-6(7)5-8/h6,8H,2-5H2,1H3
InChIKey: VCOJPHPOVDIRJK-UHFFFAOYSA-N
EINECS: 251-981-9
Product Categories: chiral;Chiral Reagent
Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 23-24/25-36-26
S23:Do not breathe vapour.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany: 3
F: 8-10-23
Hazard Note: Irritant
Specification
N-Methyl-L-prolinol (CAS NO.34381-71-0) is also named as (1-Methyl-2-pyrrolidinyl)methanol ; (1-Methylpyrrolidin-2-yl)methanol ; 2-Pyrrolidinemethanol, 1-methyl- ; 1-Methyl-2-pyrrolidinemethanol ; 1-Methylpyrrolidine-2-Methanol . N-Methyl-L-prolinol (CAS NO.34381-71-0) is white to light yellow crystal powder.